The San Francisco 49ers and Dallas Cowboys are set to meet for the eighth time in the playoffs. Not only is this one of the best rivalries in the NFL, these two teams are very similar and it should make for a fantastic matchup.

To get you ready for this Wild Card matchup, here is everything you need to know from an NFL betting perspective along with our NFL picks going into Week 1 of the playoffs.

Take a look at Cowboys vs 49ers odds, injury report, betting lines and more.

49ers vs. Cowboys Matchups

49ers LT Trent Williams vs. Cowboys DE Randy Gregory: Williams is the best left tackle in the NFL, but he missed last week due to an injury. If he’s not 100 percent, this is a matchup Gregory can win off the edge with his speed and athleticism.

49ers WR Deebo Samuel vs. Cowboys CB Trevon Diggs: Samuel totaled nearly 1,800 yards from scrimmage and he’ll likely see a lot of Diggs on Sunday. Diggs has been known to give up a lot of yards, but if he can force a turnover, it might just be the difference in the game.

Cowboys RT La’el Collins vs. 49ers DE Nick Bosa: Bosa led the NFL in tackles for loss this season and is one of the most disruptive defensive ends in the NFL. Collins will have his hands full with the two-time Pro Bowl edge rusher.

RELATED: NFL Playoff Prop Bets: Most Passing, Rushing & Receiving Over Postseason

49ers vs. Cowboys Stats

11-1: The Cowboys are 11-1 ATS in their last 12 games against NFC opponents.

7-3: The 49ers are 7-3 in their last 10 road games.

127.4: The 49ers averaged 127.4 rushing yards per game during the 2021 season.

1-6: The 49ers are just 1-6 in their last seven games against the Cowboys.

31.2: The Cowboys averaged 31.2 PPG this season, most in the NFL.

49ers vs. Cowboys Moneyline

The Cowboys finished the season at 12-5 and easily won the NFC East. Meanwhile, the 49ers had to scrap and claw for their spot in the playoffs. They eventually did clinch their spot, but it took a comeback win in Week 18 in order to do so.

However, the 49ers played in the most competitive division in the NFL with two other teams from the NFC West making the playoffs. They are battle-tested in a way that the Cowboys aren’t and they have a veteran team that is built for the playoffs. This game should be extremely close, but the value here is on San Francisco. Take the 49ers (+145) to win this game outright as they have been one of the league’s best road teams this season.

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49ers vs. Cowboys Point Spread

If the moneyline is too risky of a bet, consider taking the 49ers on the point spread. They played in a bunch of close games this season, including a few last-second losses to the Titans, Packers and Cardinals. But if this game ends up coming down to the final kick, the 49ers have one of the league’s best kickers in Robbie Gould. In a game in which both teams are so close in terms of talent, it might be the difference between winning or losing.

The Cowboys are home favorites, but they are only favored by three. Dallas doesn’t have much of a home-field advantage in terms of crowd noise and there have been some rumblings about 49ers’ fans buying up a bunch of tickets for this game. On paper, the Cowboys are the better team with the No. 1 ranked offense in the NFL. However, the 49ers are just a bad matchup for them with their elite rushing attack and dominant pass rush. Again, expect this game to be incredibly close. But take the 49ers +3 (-110) on DraftKings as they are just the better value.

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49ers vs. Cowboys Totals

No Wild Card game has a bigger point total than this one at 50.5. That makes sense considering both teams finished inside of the top-10 in scoring offense. However, Round 1 playoff games tend to be a bit sloppy and hard-fought. There are some nerves that set in and that usually results in low-scoring first halves.

Expect the scoring to pick up in the third and fourth quarters, but for both teams to lean on their run game and defense in the first half. Take the Under 50.5 (-110) on Caesars Sportsbook and expect a 24-22 type of game in Dallas between these two extremely physical teams.

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