There are sixteen fourth round matches taking place this weekend including a clash between Cardiff City and Manchester City
The FA Cup fourth round promises to throw up some exciting matches, with Yeovil Town hoping to spring an upset at Huish Park on Friday night.
The Glovers have little to lose against a Manchester United side who are among the favourites to win this trophy, with the League Two team hoping to cause an upset in front of the BBC cameras.
On Saturday lunchtime, Peterborough United clash with Leicester City at London Road, with Posh having beaten Aston Villa in the previous round and they have the firepower to cause the Foxes a few problems.
There are a spate of Saturday afternoon clashes taking place and Wigan Athletic will be among the lower league sides confident of an upset when they clash with West Ham, while the Saturday teatime clash sees Newport go up against Tottenham Hotspur.
It will be interesting to see what sort of team Spurs field at Rodney Parade, with Mauricio Pochettino hoping to get the job done with a weakened side, while there are also likely to be changes when Liverpool clash with West Brom on Saturday evening.
On Sunday lunchtime, we have Chelsea clashing with Newcastle United and the Blues are strong favourites to come through that clash, while Manchester City then play Cardiff City and it could be a tricky encounter for a side still pursuing the quadruple.
FRIDAY 26TH JANUARY
Sheffield Wednesday 19:45 Reading
Yeovil Town 19:55 Manchester United
SATURDAY 27TH JANUARY
Peterborough United 12:30 Leicester City
Huddersfield Town 15:00 Birmingham City
Hull City 15:00 Nottingham Forest
Middlesbrough 15:00 Brighton & Hove Albion
Millwall 15:00 Rochdale
Milton Keynes Dons 15:00 Coventry City
Notts County 15:00 Swansea City
Sheffield United 15:00 Preston North End
Southampton 15:00 Watford
Wigan Athletic 15:00 West Ham United
Newport County 17:30 Tottenham Hotspur
Liverpool 19:45 West Bromwich Albion
All odds were correct at time of posting.