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By Adam Thompson | | 14 mins

NFL Week 13 Odds: Moneylines, Spreads & Totals Plus Analysis

NFL Week 13 Odds: Moneylines, Spreads & Totals Plus Analysis

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There are 17 games and 18 weeks in the 2021 NFL season. Some NFL teams will have their playoff hopes damaged big-time in Week 13. There are at least four games on the NFL schedule this week that could see one team put itself in a solid position to contend, while another will find it a big uphill climb down the stretch. For those planning on some NFL betting on NFL Week 13 odds, these things must be taken into consideration before making NFL picks.

The Cincinnati Bengals (7-4) host the Los Angeles Chargers (6-5), led by young QBs Joe Burrow and Justin Herbert. Each has an above-.500 record, but one will hold a critical tiebreaker over the other.

The Steelers (5-5-1) host the Ravens (8-3) in a game Pittsburgh especially needs. Same goes for the Seahawks (3-7), who need to start winning right now for any chance when they host the surging 49ers (6-5), who have won three straight.

Prime time offers two key AFC showdowns. The Chiefs (7-4) have won four straight and have owned the Broncos (6-5) in recent years. They face off on Sunday night. Meanwhile, nobody wants to go to Buffalo or New England in January, but a home playoff game may be on the line on Monday when the Bills (7-4) host the Patriots (8-4).

So much drama in these NFL Week 13 lines at betting sites, so let’s dive right in.


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Thursday, Dec. 2

The Dallas Cowboys closed as 6.5 favorites over the host New Orleans Saints and cruised to a 27-17 victory to cover. The over/under was 47.5, and the under hit.

Sunday, Dec. 5

New York Giants at Miami Dolphins (-6), 1 p.m. ET

The Giants couldn’t move the ball much, but they also didn’t turn it over while forcing four Eagles turnovers in a 13-7 home win. New York is 3-4 in its last seven games, and it’s clear the winning trend is on the defensive side. It’s allowed 8.6 ppg in the three victories and 33 ppg in the four defeats.

Don’t look now, but the Dolphins have won four in a row. A defense that ranked 29th vs. the pass going into Week 12 held Cam Newton to 5-of-21 passing with two INTs in a 33-10 rout. Miami’s defense has forced 11 turnovers in those four victories. QB Tua Tagovailoa has 10 incompletions the last two weeks combined. The Giants defense ranks 27th in QB percentage.

Take a look at Giants vs Dolphins odds, injury report, betting lines and more.

Indianapolis Colts (-10) at Houston Texans, 1 p.m. ET

The Colts got away with what had been working in Week 12, namely handing the ball to Jonathan Taylor. They rushed for only 107 yards in a 38-31 loss to the Buccaneers. They’re now 0-6 when they gain fewer than 125 yards on the ground, and 6-0 when they gain more. When QB Carson Wentz gets 35-plus attempts, Indy is 0-5. Indianapolis is one of the biggest favorites in NFL Week 13 spreads, including at FanDuel. If you are a new bettor, you can also land a $1,000 risk-free bet by using our FanDuel promo code.

No offense can match the futility of the Texans, who ranked last in yards gained (271 per game) prior to managing even fewer - 202 - in a 21-14 home loss to the Jets in Week 12. The last time the offense gained a league-average 350 was Week 6 – vs. the Colts. Granted, Indy still won that game 31-3.

Take a look at Colts vs Texans odds, injury report, betting lines and more.


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Minnesota Vikings (-7) at Detroit Lions, 1 p.m. ET

The Vikings are 5-6, however all but one game has been decided by eight points or less. Now they must win the close ones without workhorse RB Dalvin Cook. That said, they were 2-0 in the games Cook missed with an injury, and the offense has averaged 418.5 ypg in those two games, against 344 ypg when Cook played (minus OT games).

The Lions let slip a legit chance at win No. 1 on Thanksgiving, instead falling 16-14 at home to the Bears. Six holding penalties and only 239 total offensive yards once again weren’t enough to help a Detroit defense that is fighting. The Lions have been held to 250 yards or less in three of the last four weeks.

Take a look at Lions vs Vikings odds, injury report, betting lines and more.

Philadelphia Eagles (-7) at New York Jets, 1 p.m. ET

The Eagles had won three of four but laid a big egg vs. the rival Giants in Week 12 thanks to four turnovers, including three Jalen Hurts INTs. They managed just six points, this after posting 30-plus in three of four. The defense did its part, limiting the Giants to only 264 yards, its best effort vs. a team not named the Lions.

Zach Wilson managed just 145 yards passing with no TDs and one of the uglier INTs you’ll see in his return from injury, but the Jets still got the win over the Texans. That’s due to a defense that limited Houston to only 202 total yards, not bad considering it had allowed 456 ypg the previous five games.

Take a look at Jets vs Eagles odds, injury report, betting lines and more.

Arizona Cardinals (-7.5) at Chicago Bears, 1 p.m. ET

The Cardinals were projected by many sportsbooks and pundits to finish fourth in the NFC West. Instead, they’re the No. 1 team in the NFL going into Week 13 with a 9-2 record, exciting news for Arizona sports betting fans. They’ve gone 2-1 in three games without star QB Kyler Murray, who is expected back – as is top WR target DeAndre Hopkins – for this one following Arizona’s bye week.

Bears coach Matt Nagy is still in charge, this after Chicago edged the winless Lions 16-14 on a last-second FG on Thanksgiving. A defense that ranks 10th in yards allowed carried the team again, though Andy Dalton passed for 317 yards. Who will get the QB start this week is TBD, but Chicago is 2-1 when Dalton gets the ball and 2-6 when Justin Fields starts.

Take a look at Bears vs Cardinals odds, injury report, betting lines and more.


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Los Angeles Chargers at Cincinnati Bengals (-3), 1 p.m. ET

The Chargers have gone how QB Justin Herbert has gone. They’re 5-1 when Herbert throws two TDs or more, 1-4 when he doesn’t. They’re 5-2 when Herbert goes for 280-plus pass yards, 1-3 when he doesn’t. Cincinnati ranks in the bottom 10 in pass yards allowed but top-five in fewest TDs allowed through the air.

The Bengals made a big statement against a Steelers team that had owned them over the years, blitzing to a 31-3 halftime lead en route to a 41-10 win. Joe Mixon rushed for two more TDs, giving him 12 in eight games, and Joe Burrow only needed to pass for 190 yards. Cincy is 3-0 when Burrow has under 200 yards passing. The Chargers rank fifth vs. the pass and 32nd vs. the fun.

Take a look at Bengals vs Chargers odds, injury report, betting lines and more.

Tampa Bay Buccaneers (-10.5) at Atlanta Falcons, 1 p.m. ET

When Leonard Fournette and Rob Gronkowski perform, the Buccaneers are a total force. Tom Brady didn’t have his best game vs. the Colts in Week 12, but the two other veterans did in a 38-31 win. Fournette totaled four TDs and Gronk had seven receptions for 123 yards. The Bucs’ strengths are clear, as they lead the NFL in pass yards gained and fewest rush yards allowed. Tampa Bay has blasted Atlanta by 17 and 23 the last two meetings, and NFL Week 13 odds see them as a big favorite, including at BetMGM, where you can use the BetMGM bonus code to get a $1,000 risk-free first bet.

The Falcons managed only six points the two previous weeks before scoring 21 in a victory over the Jaguars in Week 12. They were outgained but won the turnover and time of possession battles. Still, their five wins is the most they’ve had in three seasons.

Take a look at Buccaneers vs Falcons odds, injury report, betting lines and more.

Jacksonville Jaguars at Los Angeles Rams (-12.5), 4:05 p.m. ET

Jacksonville outgained Atlanta but lost 21-14, the fourth time the Jaguars have finished with more yardage but an L in the standings. One big reason, and huge issue, remains turnovers. Jacksonville has only forced five turnovers all year, while committing at least one in in nine of 10 games.

The Rams aren’t the opponent to rely on to help out. L.A. is 0-4 when they lose the turnover battle and 7-0 when they don’t. Not all is well in L.A. however, as Matthew Stafford has tossed three pick-6 INTs the last three weeks and the Rams have dropped three straight. They’re also a perfect 6-0 against sub-.500 opponents, and the Jaguars definitely fit into that category, which is why they are the biggest favorites in early NFL Week 13 odds.

Take a look at Rams vs Jaguars odds, injury report, betting lines and more.

Washington Football Team at Las Vegas Raiders (-2.5), 4:05 p.m. ET

Washington is now just getting healthy, this after consecutive wins over the Buccaneers and Panthers and a bye week. Taylor Heinicke has four TDs and no INTs during the short win streak whereas he tossed at least one pick in six of the first eight games. In wins, he has nine TDs and one INT, with six TDs and eight INTs in losses. Vegas’ defense has just four INTs in 11 games.

It’s not the Bills or the Buccaneers or Chiefs who own the No. 1 offense in the NFL. It’s the Raiders, whose 420 yards per game ranks at the top of the NFL. Vegas ranks in the top six in both rushing and passing and is coming off its best performance of the year, a 509-yard outburst in a 36-33 Thanksgiving win over the Cowboys.

Take a look at Washington vs Raiders odds, injury report, betting lines and more.

Baltimore Ravens (-4.5) at Pittsburgh Steelers, 4:25 p.m. ET

Running the ball and stopping the run has been the path to success for the AFC North-leading Ravens. That’s good news going up against a Steelers team that ranks 28th and 29th, respectively, in those categories. Keeping Lamar Jackson upright will be key. No team has allowed more sacks than the Ravens, and the Steelers defense ranks third in sacks.

No team can boast the level of inconsistent play like the Steelers, who owned a three-game losing streak, then won four in a row, and now come into this critical AFC North showdown on a two-game skid, this after salvaging a tie with the winless Lions. Ben Roethlisberger hadn’t thrown an INT for five straight games but tossed two, including a pick-6, in a 41-10 rout by the Bengals in Week 12. Pittsburgh did sweep Baltimore last year.

Take a look at Steelers vs Ravens odds, injury report, betting lines and more.

San Francisco 49ers (-3.5) at Seattle Seahawks, 4:25 p.m. ET

Deebo Samuel has become the reverse-Christian McCaffrey, a WR who can also run with brutal effectiveness. Over the last three games, Samuel has rushed 19 times for 181 yards and four TDs. He eclipsed 1,000 yards receiving in Sunday’s win over the Vikings. San Francisco has, perhaps not coincidentally, won three straight, and the offense has scored 30-34 points in each.

Seattle has lost five of six, the lone win vs. the downtrodden Jaguars, and Russell Wilson hasn’t been himself since returning from finger surgery. No facet of the team is working; the squad ranks last in the NFL in yards allowed and third-worst in yards gained. One reason for optimism: Seattle has bested San Francisco in three straight meetings.

Take a look at Seahawks vs 49ers odds, injury report, betting lines and more.

Denver Broncos at Kansas City Chiefs (-9.5), 8:20 p.m. ET

Teddy Bridgewater has just three TDs in the last four games for Denver, but he also doesn’t have an interception, and the turnovers have been the key as the Broncos have won three of four to shake off a four-game losing streak. Denver ranks top 10 defensively vs. both the run and the pass. The Broncos have never beaten Patrick Mahomes, though the QB has a modest five TDs over the last four games against them.

Many wondered what was wrong with the Chiefs five weeks ago. But now they’ve won four straight and come out of their bye week healthy and on a roll. The defense hasn’t allowed over 17 points during the streak. While the Chiefs are a perfect 5-0 against NFC opponents, they’re just 2-4 vs. the AFC. But they’ve beaten the West-rival Broncos 11 straight times.

Take a look at Chiefs vs Broncos odds, injury report, betting lines and more.

Monday, Dec. 6

New England Patriots at Buffalo Bills (-3), 8:15 p.m. ET

The Bills handled the Patriots twice last season but had only beaten them three times the 17 years prior. New England has won six straight; its defense has held the last four opponents to an average of 6.0 points and 244 yards. After tossing six INTs in the first six games, rookie QB Mac Jones has two over the last six games.

The Bills either show up or they don’t. All seven of their wins have been by double figures, but their four losses include a 26-point drubbing by the Colts and a dud vs. the hapless Jaguars. Statistically, no team is as dominant as Buffalo, which ranks No. 2 in scoring and in points allowed. Its strength of schedule, however, ranks among the lowest. It's a shame online New York sports betting is not live for this one.

Take a look at Bills vs Patriots odds, injury report, betting lines and more.

Teams on Bye Week: Carolina Panthers, Cleveland Browns, Green Bay Packers, Tennessee Titans

NFL Week 13 Opening Odds vs Current Odds

Game matchupOpening SpreadCurrent Spread
New York Giants at Miami DolphinsDolphins -2.5Dolphins -6
Indianapolis Colts at Houston TexansColts -7Colts -10
Minnesota Vikings at Detroit LionsVikings -7.5Vikings -7.5
Philadelphia Eagles at New York JetsEagles -6.5Eagles -7
Arizona Cardinals at Chicago BearsCardinals -7Cardinals -7.5
Los Angeles Chargers at Cincinnati BengalsBengals -1.5Bengals -3
Tampa Bay Buccaneers at Atlanta FalconsBuccaneers -9.5Buccaneers -10.5
Washington Football Team at Las Vegas RaidersRaiders -1.5Raiders -2.5
Jacksonville Jaguars at Los Angeles RamsRams -12.5Rams -12.5
Baltimore Ravens at Pittsburgh SteelersRavens -3Ravens -4.5
San Francisco 49ers at Seattle Seahawks49ers -249ers -3.5
Denver Broncos at Kansas City ChiefsChiefs -9.5Chiefs -9.5
New England Patriots at Buffalo BillsBills -3.5Bills -3

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About the Author

Adam Thompson for
Adam Thompson
NFL writer and expert Adam Thompson joined in 2019 after a successful run as senior handicapper for SportsLine and