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College Football Week 4 Odds, Best Bets & Picks

Dan Kilbridge for Bookies.com

Dan Kilbridge  | 15 mins

College Football Week 4 Odds, Best Bets & Picks

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Two preseason top-15 teams have fallen out of the rankings completely, two coaches have already been fired and the College Football Playoff picture remains wide open. And we’re just getting started as the college football betting action continues in Week 4 of what’s shaping up like another wild, unpredictable season. 

Georgia (+175), Alabama (+210) and Ohio State (+275) are the consensus top three on the college football playoff odds board, but from there it’s anyone’s guess – with USC (+1200), Clemson (+1400) and Michigan (+1800) rounding out the top six. The rest of the field is priced at 40-1 or longer on betting apps, an intriguing scenario considering the fourth CFP spot is completely up for grabs if things progress as expected.

However, that’s not usually the case on the college gridiron. And there’s potential for further chaos entering Week 4. Clemson (-7.5) faces a tough road test at Wake Forest, Ohio State (-19) is hosting the always-dangerous Badgers and No. 20 Florida takes on No. 11 Tennessee (-10.5) in a massive SEC matchup. No matter how things ultimately shake out, we’ve got our eyes on several key college football week 4 best bets as the season heats up. 

College Football Week 4 Odds

Let's take a look at the latest college football odds for select games in CFB Week 4 of the 2022 season. Don't forget to shop around at sportsbooks and on available betting apps for the best price and college football week 4 lines.

And don't forget to keep reading down this article for our best college football picks for Week 4.

Sat, Sept. 24Maryland at Michigan (-17)65.5
Sat, Sept. 24Clemson (-7) at Wake Forest56
Sat, Sept. 24Baylor at Iowa State (-3)45
Sat, Sept. 24Duke at Kansas (-7.5)66.5
Sat, Sept. 24Florida at Tennessee (-10.5)62
Sat, Sept. 24Minnesota (-3) at Michigan State51
Sat, Sept. 24Arkansas at Texas A&M (-2)48.5
Sat, Sept. 24Wisconsin at Ohio State (-19)57

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College Football Week 4 Best Bets

Here's a look at our college football week 4 best bets, including our favorite picks for Florida vs. Tennessee and Wisconsin vs. Ohio State.

DateMatchupWeek 4 Picks
Sat, Sept. 24Maryland @ Michigan Michigan -16.5
Sat, Sept. 24Clemson @ Wake Forest Clemson -7
Sat, Sept. 24Baylor @ Iowa State Baylor +3
Sat, Sept. 24Duke @ Kansas Kansas -7.5
Sat, Sept. 24Florida @ Tennessee Florida +10.5
Sat, Sept. 24Minnesota @ Michigan State Michigan State +3
Sat, Sept. 24Arkansas at Texas A&M Texas AM -2
Sat, Sept. 24Wisconsin @ Ohio State Wisconsin +18.5

All college football week 4 picks accurate as of publication (Sept. 21) and subject to change. Use BOOKIESPICKS to get a $1,000 risk-free bet when signing up to BetMGM.

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Maryland at Michigan, Sept. 24, Noon ET

The Terrapins are 3-0 and coming off a gritty win over SMU. It was their first impressive win of the season after a pair of blowouts over Buffalo and Charlotte, and Maryland has a huge chance to prove itself as a program on the rise Saturday at the Big House. Michigan hasn’t been tested at all in three home wins over Colorado State, Hawaii and UConn – three of the worst teams in the country. Maryland quarterback Taulia Tagovailoa taking on the Wolverines secondary is the matchup to watch here. For Maryland sports betting fans, legal online betting could be coming to your state as soon as early 2023.

This will be a crash-course for a Michigan secondary that currently ranks third in the nation. The Terps figure to test the Wolverines through the air early and often and we wouldn’t be surprised if they have some early success. We just don’t see them sustaining it for four quarters. The jury is still out on the Wolverines as real CFP contenders again, but they should pull away in the second half for another blowout win and cover. 

Best Bet: Michigan -16.5

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Clemson at Wake Forest, Sept. 24, Noon ET

Wake Forest is just one year removed from the ACC title game and survived a scare in last week’s 37-36 win over Liberty. Now the Demon Deacons can quickly shift focus as home underdogs against the Tigers, who own a 13-game win streak over Wake Forest. This looks like one of the most evenly-matched yet on paper, one which could have massive ACC title and College Football Playoff implications down the road.

It’s also a chance for the Tigers to prove they’re back among the nation’s elite, and we expect them to get it done in convincing fashion against a flawed Demon Deacons squad. 

Best Bet: Clemson -7

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Baylor at Iowa State, Sept. 24, Noon ET

The Cyclones are a slight favorite over the Bears on betting sites, who are getting points for the second time in four games. Baylor failed to cover in a road loss at BYU but has a chance to get right back in the national picture with an upset win in Ames. We’ll see if Iowa State can keep the momentum going at 3-0, including a 10-7 win at rival Iowa. Another massive early conference matchup here as the Big 12 title picture beings to take shape. 

Baylor is balanced and dangerous on offense and the Cyclones could be in for a rude awakening. They’ve put up impressive defensive numbers, but it’s come against an FCS opponent, a bottom-tier MAC squad and an Iowa team that ranks dead last in total offense. The Bears gained valuable experience in a double-overtime loss at BYU and should be ready to start conference play with a big road win. 

Best Bet: Baylor +3

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Duke at Kansas, Sept. 24, Noon ET

Duke heads to Kansas for one of the most stunning matchups of unbeaten teams we can recall. These two teams combined for five wins all of last season, already surpassing that number in Week 4 with matching 3-0 records. They’ve each had impressive wins – Duke at Northwestern and Kansas over West Virginia and Houston. Kansas is favored by less than 10 points and what looked like the worst game of the week back in August suddenly has our attention – especially with legal Kansas sports betting now underway in the state. 

Both teams can run the ball, but the Jayhawks are on another level and rank second in the nation at 7.13 yards per rushing attempt. That’s thanks in large part to dual-threat quarterback Jalon Daniels, who ran for 123 yards in last week’s win at Houston and can take over the game if necessary. We don’t see the Blue Devils keeping him contained. 

Best Bet: Kansas -7.5

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Florida at Tennessee, Sept. 24, 3 p.m. ET

It’s a good old-fashioned SEC Game of the Week as the Florida Gators head to Knoxville looking to shake off a home loss to Kentucky and a too-close-for-comfort 31-28 win over South Florida. The defense is tasked with slowing down one of the most prolific offenses in the country, and tuning out the crowd in what should be one of the best gameday environments you’ll ever see at Neyland Stadium.

This Gators defense is legit, especially in the secondary, and Florida should be able to slow a Tennessee offense that has destroyed two MAC teams but managed just 27 points in regulation against Pitt. There’s still too many unknowns here to lay two scores, especially with the Gators looking to avoid their first 0-2 start in SEC play since 1986.

Best Bet: Florida +10.5

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Minnesota at Michigan State, Sept. 24, 3:30 p.m. ET

The Spartans are home dogs and doing a bit of soul-searching after getting demolished last weekend at Washington. Michigan State gave up nearly 400 passing yards against the Huskies, a massive concern for a team that finished dead last in passing yards allowed per game last season. Minnesota is strong and balanced on offense, and it’s gut-check time for a Spartans defense that didn’t answer the bell in Seattle. 

We expect Michigan State to answer the bell. The front seven remains strong against the run and that’s where Minnesota has been doing the bulk of its work offensively. The Gophers’ numbers are inflated having played arguably the weakest schedule in the country through three games, and they haven’t won in East Lansing since 2006. 

Best Bet: Michigan State +3

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Arkansas at Texas A&M, Sept. 24, 7 p.m. ET

The Aggies bounced back from the Appalachian State upset with an impressive, if not spectacular home win over Miami. We’ll see if the offense can keep pace with the No. 10-ranked Razorbacks, who opened as slight road underdogs after three wins over Cincinnati, South Carolina and Montana State. The offense is putting up big numbers, but oddsmakers expect more of a grind with the total opening at just 48.

This is a really tough one to call given what we’ve seen from both teams. Arkansas’ secondary has been shaky at best and if the Aggies are ever going to get that passing attack going, this is the week to do it. 

Best Bet: Texas A&M -2

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Wisconsin at Ohio State, Sept. 24, 7:30 p.m. ET

Two of the best in the Big Ten are at it in primetime with the Badgers heading to Columbus as three-score underdogs. Ohio State looked rusty in a 21-10 season-opening win over Notre Dame, but the Buckeyes are back on track after a pair of blowout wins over Arkansas State and Toledo. Same goes for the Badgers, who responded to a home loss against Washington State with a 66-7 win over New Mexico State. 

This is always an interesting contrast of styles. The Buckeyes have won eight straight over the Badgers, most recently a 34-21 triumph in the Big Ten title game. But five of those eight wins have been by single-digits, and we could see another closer-than-expected conference matchup at the Horseshoe. 

A close win over Notre Dame in Week 1 has not aged well for the Buckeyes, and Wisconsin’s defense is the real deal. The Badgers don’t have the weapons to go shot-for-shot with Ohio State, but they have enough to keep it from getting completely out of hand. 

Best Bet: Wisconsin +18.5

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About the Author

Dan Kilbridge for Bookies.com
Dan Kilbridge
Handicapper Dan Kilbridge writes about college football, MLB and other sports for Bookies.com after spending three years covering Tiger Woods’ comeback and the PGA for Golfweek.