Historically, it’s been the very definition of a mismatch. Indiana hasn’t beaten Ohio State since 1988, losing 26 of the last 27 against the Buckeyes with one tie thrown in. The Hoosiers haven’t won in Columbus since 1987. The Buckeyes’ average margin of victory over the past decade has been three touchdowns — just about the same point spread for Saturday’s matchup in Ohio Stadium.

Of course, the difference this time is that Indiana has its best team in a generation, one that’s unbeaten and ranked ninth in the AP Top-25. The Hoosiers are dynamic and feisty, but No. 3 Ohio State represents their toughest challenge yet. Will history repeat itself, or will Indiana make history? Let’s break down the college football betting angles on the Game of the Week.

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Best Indiana vs Ohio State Betting Lines & Picks

College football odds current as of publication; compare the latest Indiana vs Ohio State odds here.

Indiana vs Ohio State Spread Prediction

Indiana is powered by some tremendous skill position players. Quarterback Michael Penix Jr. is a dual-threat standout whose lunge for the pylon against Penn State will be remembered in the Hoosier State forever. Receiver Ty Fryfogle burned Michigan State last weekend for 200 yards and two scores. And tailback Stevie Scott is a tough-to-tackle runner who gives Indiana a very well-rounded attack.

Coach Tom Allen has instilled an energy and toughness that’s evident on the field. The Hoosiers are unbeaten against the spread so far this season, winning outright twice as an underdog. There are enough weapons on that Indiana roster, and enough belief on that Indiana sideline, for the Hoosiers to avoid getting blown out. Bet on Indiana getting the points with PointsBet.

Indiana vs Ohio State Moneyline Pick

Ohio State blew out Indiana 51-10 last season in Bloomington, though Penix missed that game with a shoulder injury. Add Indiana’s offensive skill personnel to a defense that thrives on generating turnovers — the Hoosiers have forced 12, best in the Big Ten — and there’s enough here to get Ohio State’s attention.

The Hoosiers have already ended one long drought against a conference opponent, beating Michigan for the first time since 1987. And yet, the record of the Hoosiers’ first three opponents remains an unconvincing 3-13.

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Indiana’s secondary hasn’t been tested by a quarterback like Ohio State’s Justin Fields, who has yet to throw an interception this season. As good as Indiana is at so many positions, Ohio State is just better. That Buckeyes moneyline presents no value, but it’s also the only logical choice if you feel you must. Back the Buckeyes at BetMGM.

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Indiana vs Ohio State Totals Betting

Indiana has gone over the total in three of its first four games this season, the exception being a 24-0 rout of Michigan State last week. Ohio State went over in its most recent victory over Rutgers, before having to cancel last week’s game against Maryland because of a coronavirus outbreak among the Terps.

Ohio State and Indiana are two of the three highest-scoring teams in the Big Ten, averaging 46.3 and 33.8 points respectively, and both squads are loaded with playmakers. Despite a string of easy victories, Ohio State is still allowing an average of 23 points per game, so the Hoosiers are going to put some numbers on the board. All signs point to the Buckeyes winning in the neighborhood of 42-24. Grab the best odds on the Over with DraftKings.

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