Stanford pulled one of the shockers of the season last Saturday, upsetting Oregon in overtime as 8.5-point home underdogs to throw yet another wrench into the College Football Playoff picture. Now we see whether the Cardinal can keep it going, this time on the road against another contender in the Pac-12.

Arizona State has won two straight, both overall and against the spread, since losing as a favorite at BYU, which in retrospect shouldn’t have been a surprise. The Sun Devils are coming off their best performance of the season, an easy victory at UCLA, and now welcome a Stanford team that’s covered three of four.

With a Friday night spotlight to themselves, expect these college football odds to attract lots of interest, especially from Arizona sports betting fans.

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Odds are current as of publication. Betting sites may adjust odds as we get closer to kickoff.

Stanford vs Arizona State Key Matchups

Jayden Daniels vs. Stanford’s secondary: While Stanford’s defense has struggled to stop the run, the Cardinal have been very effective against the pass - Oregon QB Anthony Brown last week completed just 14 of 26 attempts for 186 yards with one pick. Arizona State’s Daniels might be the best QB in the league, and Stanford’s hopes Friday begin with shutting him down.

Rachaad White vs. Stanford’s front seven: And yet the Sun Devils have a very capable tailback in White, who’s averaging 5.2 yards per carry and has scored eight TDs. Oregon gashed the Cardinal last week for 228 yards on the ground, and Arizona State has the personnel to turn in a similar effort to take the pressure off Daniels.

Stanford’s offensive line vs. Darien Butler: Stanford’s standout QB Tanner McKee may need help staying upright. Arizona State has a very good pass rush keyed by Butler, a linebacker with two sacks and six tackles for loss. Oregon notched five TFLs against the Cardinal last week, and ASU averages over three sacks per game.

5 Key Stanford vs Arizona State Stats

10-8: Stanford’s record as a road underdog under current head coach David Shaw, hired before the 2011 season.

6-1: Stanford’s record in its last seven meetings with Arizona State, though the teams have not played since 2018.

3-2: The record of both Stanford and Arizona State against the spread this season.

17.4: The average points per game allowed this season by Arizona State’s defense, best in the Pac-12.

212.8: The average rush yards per game allowed this season by Stanford’s defense, last in the Pac-12.

Stanford vs Arizona State Weather Forecast

It’s the desert, so no surprise - early forecasts for Friday night in Tempe, Ariz., call for temperatures in the low 80s at kickoff, and zero chance of rain. Humidity will also be low, so expect a comfortable evening for spectators and college football betting devotees alike.

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Stanford vs Arizona State Moneyline

Arizona State is a -425 moneyline favorite and Stanford a +320 underdog, according to sportsbooks. While it’s not easy to trust Herm Edwards as an in-game strategist, the Sun Devils have clearly found their stride the past two games, looking formidable against Colorado and UCLA.

Stanford’s improved as well, with a QB in McKee who leads the Pac-12 in TD passes. But they haven’t seen a defense like Arizona State’s, and combine that with the Sun Devils’ balanced offense and the road setting, and it’s easy to like ASU straight-up - but pass on this moneyline.

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Stanford vs Arizona State Point Spread

Arizona State is a 10.5-point spread favorite, according to betting apps. The Sun Devils covered a bigger number against Colorado two weeks ago, and won at UCLA as an underdog. Stanford has been competitive in every game it’s played since its dud of an opener against Kansas State, which it appears to have left behind.

The Cardinal upset Oregon, was tied with UCLA in the fourth quarter, and beat USC as a 17.5-point underdog. Four weeks running, all of Stanford’s games have been close - and we expect more of the same in Tempe, where the Cardinal seem very capable of covering that double-digit spread. You can get Stanford +10.5 (-105) at DraftKings.

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Stanford vs Arizona State Totals

The total is 52, according to betting sites. Over the past four weeks, Stanford games have totaled 55, 59, 64 and 70 points, and McKee is thriving in Shaw’s offense. But Arizona State’s defense will set the tone, something it did even in its low-scoring loss at BYU.

Only once this season has an ASU game totaled more than 52 points. The Sun Devils have allowed fewer than three opposing TDs per game since Edwards took over, they’re better than anyone else in the Pac-12 at getting pressure on quarterbacks, and the under seems among the most sensible of college football picks this week. You can get Under 52.5 (-115) at FanDuel.

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