49ers vs Cardinals Same Game Parlay Picks for NFL (Nov 16th, 2025)

By Bookies.com Nov 13th, 2025 2:13 PM EST

3CM57F3 Arizona Cardinals quarterback Kyler Murray warms up prior to an NFL football game against the Carolina Panthers, Sunday, Sept. 14, 2025, in Glendale, Ariz. (AP Photo/Ross D. Franklin)

State Farm Stadium has witnessed the Cardinals cover as underdogs in both of their last two meetings with San Francisco. The upcoming November 16th NFL slate features Arizona’s offense, which has churned out over 140 rushing yards per game lately against the Niners. Recent clashes between these teams have also seen totals push past forty points more than once. Given these performance notes and player trends, this Sunday brings several angles for NFL same game parlay picks.

49ers vs Cardinals Same Game Parlay Picks (Nov 16th, 2025)

Pairing a Cardinals spread bet with team total over leverages both their resilience and offensive production at home. Adding Marvin Harrison Jr.'s touchdown exploits his increased red zone role against San Francisco's defense. George Kittle complements by targeting his strong away-game scoring record for a balanced approach on both sides of the ball.

Pick 1: Point Spread – Arizona Cardinals +2.5 – -104

Arizona has covered the point spread in each of its previous two matchups versus San Francisco when starting as an underdog. This trend highlights how well they respond to divisional pressure at State Farm Stadium specifically. Their ability to keep games tight bodes well for another close result here, especially given improved backfield production this season. Arizona’s defensive adjustments may slow down early Niners surges enough to stay inside this margin again.

Pick 2: Total Points – Over 43.5 – -206

Two out of the last three meetings between these squads finished above forty total points scored combined, indicating offensive tempo is often elevated in these games regardless of venue or personnel shifts year-over-year. Both units favor pace-driven football styles that open up scoring windows from multiple positions on each roster throughout four quarters.

Pick 3: Team Total – Arizona Cardinals Over 23.5 – +105

The Cardinals’ ground attack averaged more than one hundred forty rushing yards across their previous three tilts opposite San Francisco’s front seven, underscoring sustained success moving the chains via run-heavy schemes lately within NFC West playbook showdowns like this one promises to be again Sunday afternoon.

Pick 4: Anytime Touchdown Scorer – George Kittle – +135

George Kittle remains a trusted target during high-leverage plays on foreign turf—a pattern evidenced through robust reception numbers and end-zone opportunities whenever traveling westward into division rival territory particularly post-bye stretches historically noting reliably spiked outputs across various measured splits since entering professional ranks equates meaningful upside chasing another score while defenses key upon secondary receivers instead because placement dictates mismatches toward seam routes executed cleanly by top-tier tight ends such as himself irrespective opposing scheme tweaks deployed week-to-week leading into Thanksgiving schedule crunches annually now established calendar fixture tradition.

Pick 5: Player Touchdowns – Marvin Harrison Jr. Over 0.5 – +145

Marvin Harrison Jr.’s involvement near paydirt ramps up with every appearance; he garners reliable snaps during crucial sequences just outside goal-to-go situations making him poised for higher-value touches compared other receiving options presently featured by Arizona coordinator designs around Kyler Murray-led drives late second/early fourth quarter periods where fatigue sometimes erodes coverage assignment discipline league-wide statistically documented patterns emerge weekly among rookie wideouts benefiting continually expanding route trees midseason onward especially after bye weeks reset positional depth charts subtly but markedly so consider him likely anytime scorer candidate relative odds suggest fair value proposition accordingly here too now still priced attractively marketwide pregame kickoff projections.

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