Week 2 in the NFL is not for the faint of heart. It’s the easiest time all year to overreact to what we saw from the previous week. A lot of NFL betting is based on matchups each week, rather than trying to figure out how a team duplicates the previous performance.

That works for both teams coming into this matchup, as the Eagles won’t be anywhere near as good as they were against the Falcons, nor will the Niners look so passive as they did in the second half against the Lions.

The line opened at 3 and now has the Eagles getting the hook at +3.5 at home. Safe to say sportsbooks won’t have this number crossing through 3, but giving Jalen Hurts and that offense 3.5 points at home against anyone sounds reasonable.

Both offenses can move the ball despite the Niners backfield dealing with a Raheem Mostert injury. Looking at the NFL spreads last week, we saw 13 dogs cover, something to keep in mind with this game.

From Devonta Smith to George Kittle, this matchup is loaded with big-play talent, making that total of 50 more than attainable. The Niners are a -180 favorite on the ML compared to the Eagles getting a +165 return.

RELATED: NFL Week 2 Odds & Betting Lines and be sure to check out more Eagles vs. 49ers odds.

Niners vs. Eagles Key Matchups

SF Pass Rush vs. Eagles OL: This is the most important matchup of the entire game. The Niners boast a pass rush infinitely better than the Falcons, and the Eagles offensive line is one of the best in the NFL. Getting to Hurts is the key to stopping the Eagles, just like protecting Hurts is the key to beating the Niners.

Devonta Smith vs. Deebo Samuel: Neither one of these guys will be going against one another, but they will be competing in one of the game’s most important matchups, big plays. Both Smith and Samuel can take the game over with their speed and spacing, it’s just a matter of who has more volume going their way. Samuel fueled a defeat of Detroit last week, while Smith did just enough to crush the Falcons.

Nick Sirianni vs. Demeco Ryans: The first-year head coach/play-caller taking on the first-year defensive coordinator for SF. This will be a fascinating matchup of chess, as whoever makes the best halftime adjustment will win this game.

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Niners vs. Eagles Key Stats

0: That’s how many points the Falcons scored in the second half last week. This is a team that still boasts a ton of talent around a veteran QB, and the Eagles defense suffocated them. It’s early in the season, but making NFL picks based off Week 1 domination isn’t always a bad thing.

23: That’s how many second-half points the Niners defense gave up to the Lions offense last week. While SF was up convincingly in the first half, Detroit took full advantage of the Niners playing prevent everything.

19/104/1: Elijah Mitchell’s stat line last week following the season-ending injury to Raheem Mostert. Just because the Niners are down a running back doesn’t mean they don’t have two young kids – Mitchell and Trey Sermon – to lean on in Philadelphia.

5.6: This is what the Eagles averaged per rush last weekend on their way to gashing the Falcons. Philadelphia only used Miles Sanders and Kenny Gainwell on the ground, mixing in a healthy dose of Hurts.

11.8: Devonta Smith averaged this per reception against one of the worst secondaries in the league. The Niners are down a CB and Smith might be able to duplicate a strong performance come Sunday afternoon.

RELATED: NFL Week 2 Odds & Betting Lines For All 16 Matchups

Niners vs. Eagles Player Props

Jalen Hurts, Over 250 Pass Yards

Odds: +110 at PointsBet

Hurts threw for 264 last week in a snooze-fest come the second half. He will have 35-40 attempts and his team should stretch it more than they did against Atlanta.

Brandon Aiyuk, Over 75 Receiving Yards

Odds: +110 at PointsBet

With so much discussion about his disappearance last week combined with Samuel dominating the Lions, this has huge game written all over it for Aiyuk, especially with a favorable matchup.

George Kittle, Over 125 Receiving Yards

Odds: +300 at PointsBet

Monster number but the only one on both teams who has the volume combined with ability to hit that number. Don’t be shocked if Kittle comfortably reaches 125.

Niners vs. Eagles Moneyline

This is an even matchup when you look at each of the key battles, with the Niners' task being to slow down Hurts, and the Eagles finding a way to penetrate a ridiculously good SF offensive line.

It’s a game truly won in the trenches with neither side owning any major or noticeable advantage. Jimmy Garoppolo won’t be asked to take many risks, nor will Hurts be asked to throw the ball more than 40 times. It’s a lot to lay here, but SF -180 at DraftKings is the play .

Keep checking betting sites to see if this dips, as it’s safe to expect more local Eagles money coming in at Pennsylvania sports betting sites by kickoff.

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Niners vs. Eagles Point Spread

The hook is everything here. Philadelphia has some major big-play capability, powered by some fast WRs. They also have a legit TE tandem that can beat a lot of teams deep/deep middle.

No matter how much the Niners get up on a team – as we saw last week – there’s always a threat of a run from the other side. Sitting just over that key number of 3, the Niners won’t be able to coast their way to a victory, if anything they will have to come from behind. Take the hook. Bet the Eagles +3.5 (-110) at FanDuel .

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Niners vs. Eagles Totals

While neither team wants their respective QB to throw the ball more than 40 times, both teams should have an easier time putting up points. Two things are working together to hit this Over 50 on Sunday.

Both defenses want to keep big-play receivers in front of them, like Samuel and Smith for example. By doing that, it allows the passing game to shift over to the running backs, something the Eagles thrive at executing. Expect a lot of short passes that go for chunk yardage, ultimately leading to points. Take the Over 50 (-110) at BetMGM .

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