Dallas Cowboys At Philadelphia Eagles Picks & Betting Predictions

The Dallas Cowboys and Philadelphia Eagles have each qualified for the playoffs, but positioning is at stake when the NFC East rivals face off to conclude the regular season at Lincoln Financial Field on Saturday night. Dak Prescott and the Cowboys (11-5) have already clinched a division title and are the No. 4 seed, but can move up to as high as No. 2 with a win and some help.

The Eagles (9-7) will be either the No. 6 or the No. 7 seed depending on the weekend action. Betting sites and most betting apps have Dallas at -7 in the latest Cowboys vs. Eagles NFL spreads range, a huge move from the -3.5 opening odds.

Take a look at Cowboys vs Eagles odds, injury report, betting lines and more.

Cowboys vs. Eagles Key Matchups

Jordan Howard vs. Cowboys Front 7: The Eagles are 6-1 with Howard in the backfield, even though he hasn’t scored in the last five games and has just two receptions all year. Dallas has allowed 100-plus rush yards in 10 of the last 11 games.

Dalton Schultz vs. Eagles LBs: No team has allowed more receptions to tight ends than Philadelphia. Schultz’s 75 catches, 787 yards and six TDs all rank No. 2 for the Cowboys.

Amari Cooper vs. Eagles DBs: Cooper has averaged 80 ypg vs. Philly over his career but had just three catches for 26 yards in the first matchup.

RELATED: NFL Week 18 Odds & Betting Lines For All Games

5 Key Cowboys vs. Eagles Stats

5: Sacks by the Eagles in seven home games, the lowest total in the NFL. Dak Prescott has been sacked at least three times in three of his last four games.

7: Rushing TDs allowed by the Cowboys, the fifth-lowest total in the NFL. The Eagles have more rushing touchdowns (24) than any other team.

9: The Cowboys have a plus-9 turnover ratio over the last five games. They’re 10-2 when forcing a turnover and 1-3 when they don’t.

10.9: Receptions allowed to wide receivers by the Philly defense; only the Patriots have allowed fewer.

11: Interceptions by Cowboys DB Trevon Diggs, the NFL leader by three picks. Eagles QBs have only two INTs at home.

RELATED: NFL Week 18 Picks & Best Bets For Every Game

Cowboys vs. Eagles Weather Forecast

Saturday night in Philly will be cool but good enough for football. Temperatures in the evening should be around 30 degrees, with no chance of precipitation. It’s the coldest day of the week, but warm enough for Eagles fans at Lincoln Financial Field to celebrate a postseason berth in what is likely the final home game.

Cowboys vs. Eagles Moneyline

When it comes to NFL betting on the moneyline, favored Dallas is a hefty -320 on the moneyline, while Philadelphia is set at +250. The Cowboys blasted the Eagles 41-21, though that was back in Week 3. That was before the Eagles established the league’s top run offense.

But Week 18 is a different animal. It’s difficult to assume either team’s motivations. That especially goes for the Eagles, who are going on the road as the No. 6 or No. 7 seed regardless. It wouldn’t be a shock to see them sit several key players, including Jalen Hurts. On the surface, the Cowboys have more to play for, but the odds a win improves their seeding are slim. They could sit key pieces, as well, including Dak Prescott. It’s all too risky.

Bet $5, Get $200 in Bonus Bets Instantly

Tap for Promo Activated! Visit site

Used 41 Times Today

GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). 1 per new customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 5/18/25 at 11:59 PM ET. Sponsored by DK.

Cowboys vs. Eagles Point Spread

The Cowboys are favored by about a TD on a point spread line that differs depending on the sportsbook. On the surface, with two teams at full strength, this is a great price for an Eagles team that has won nine of 11, with the two losses each by less than a TD.

The issue here is, who suits up for Philly? Top RB Miles Sanders is already out. If Jalen Hurts doesn’t play, that puts a big dent in Philly’s top asset. Gardner Minshew is a highly capable backup; Philly has an edge if Prescott sits in favor of Cooper Rush. If we’re playing a side, it’s Philadelphia with the points, but it doesn’t come without risk.

New users at BetMGM can sign up and grab a risk-free first bet worth up to $1,000 to use on the NFL. Just check out our BetMGM bonus code page for more information or hit 'Bet Now' to get started.

Bet $10, Get $150 If You Win Promo Code: BOOKIESBG150

Tap for Promo Activated! Visit site

Used 43 Times Today

Bonus Bets Expire in 7 Days. One New Customer Offer Only. Must be 21+ to participate. Gambling problem? Call 1-800-GAMBLER (CO, DC, IL, IN, KY, LA, MD, MS, NC, NJ, OH, PA, TN, VA, WV, WY) Call 877-8-HOPENY or text HOPENY (467369) (NY). Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI). Visit BetMGM.com for T&Cs. US promotional offers not available in NY, NV, or Puerto Rico.

Cowboys vs. Eagles Totals

NFL sportsbooks have posted an Over/Under of 42.5 points for this Saturday night showdown – that number has dipped from the opening line of 44.5, due to the questionable status of several key players, most notably the starting quarterbacks.

The offenses won’t die with Minshew and Rush at the helm. Each has one start; the QBs combined for 567 yards and four TDs in winning efforts. Defenses will be missing players, too, so now this number seems low. The Over has hit in the Eagles’ last four home games and the last two meetings between these teams have totaled 62 and 54. That makes the Over worth considering as part of your NFL picks package for Week 18.

Bet $1, Double Your Winnings Your Next 10 Bets Promo Code: BOOKIESDYW

Tap for Promo Activated! Visit site

Used 10 Times Today

Must be 21+ to participate. T&Cs apply.