Week 2 of the NFL betting season has the longshot potential to offer perhaps the biggest regular season matchup of the last decade. 

Potential. 

As in +10000.

Yes, that’s a longshot of the longest sort. 

The Miami Dolphins visit Gillette Stadium to face the New England Patriots. This is always an intriguing AFC East matchup. This one oddly happens to fall into the Sunday night NBC primetime slot. That seems a bit odd given that the Patriots are slotted at 7.5 wins. 

But is it? Perhaps the NFL scriptwriters have a huge surprise in store for us. 

The Dolphins are set to go with Tua Tagovailoa at QB. Tua has MVP potential this season. He’s got multiple top-tier targets. He’s mobile. He's extremely accurate. And the Dolphins should be able to run just enough to keep him ambulatory. 

But he’s also prone to injuries, especially head injuries, due to his mobility and willingness to take a hit. Tua suffered two (documented) concussions last year, among other injuries, and missed all or part of 6 games. The Dolphins went 1-5 without him for the entire game. 

What if Tua is unable to play? 

To whom would the Dolphins turn to at quarterback? 

Hint, it ain’t gonna be Skylar Thompson. 

Yep, you’re thinking what we’re all thinking.

“Crazy” you say. Well, this is the NFL. 

And The Script is The Script.

Elsewhere, the national late-afternoon game features Aaron Rodgers facing his old nemesis, the Dallas Cowboys, in a Kelly green Jets uniform. 

The week begins Thursday night with an interesting NFC matchup between the Eagles and Vikings in what could well be a playoff preview. There are two games on Monday night: New Orleans visits Carolina at 7:15 p.m. on ESPN, and the Steelers play host to Cleveland at 8:15 p.m. on ABC. 

NFL Week 2 Picks – Aaron Rodgers Goes Back To Dallas

Here are our Week 2 best bets to back on betting apps. Things are subject to change.

Thursday, September 14

Minnesota Vikings at Philadelphia Eagles, 8:15 p.m. (Amazon Prime)

Game	Bet	Pick	Best Odds
Thursday Sep 14, 08:15pm					Minnesota Vikings MIN Philadelphia Eagles PHI	Spread	Philadelphia Eagles PHI	-6 -110

This is a rematch of a Week 1 Monday night 2022 game won by the Eagles 24-7. Both teams made the playoffs last season. This game could well serve as a preview of the upcoming postseason. Jalen Hurts will hear it quick and loud if the Eagles struggle early, given the large bag of cash he received in the offseason. 

The Eagles were 10-10 overall ATS last year despite winning the NFC. But Philly finished 8-3 at home against the line. Look for movement on this number especially after Week 1. 

Best Bet: Eagles -6 (-110) at DraftKings

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Sunday, September 17

LA Chargers at Tennessee Titans, 1 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 17, 01:00pm					Los Angeles Chargers LAC Tennessee Titans TEN	Spread	Los Angeles Chargers LAC	-3.5 -103

If Justin Herbert can adjust his body clock to the Central Time zone, the Chargers could well stack several dozen points. The Titans will still be navigating in Middle Earth between Ryan Tannehill and Will Levis at QB. The “First Coach Fired” clock will be ticking on both Mike Vrabel and Brandon Staley. The Hot Seat gets plugged in following an 0-2 start. 

Best Bet: Chargers -3.5 (-110) at DraftKings

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Baltimore Ravens at Cincinnati Bengals, 1 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 17, 01:00pm					Baltimore Ravens BAL Cincinnati Bengals CIN	Spread	Cincinnati Bengals CIN	-3.5 -106

The Bengals are slight favorites over the Ravens to win the AFC North. The Bengals remain a value play to win the AFC at +550 and to win the Super Bowl at +1200. The Ravens will be playing their second consecutive game on the road to start the season. This will Cincinnati’s home opener. 

The teams split straight up and ATS last season. If this was a Week 1 matchup, the Ravens could steal it. But any wrinkles in those Cincy stripes will be gone by Week 2. 

Best Bet: Bengals -3.5 (-110) at DraftKings

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Las Vegas Raiders at Buffalo Bills, 1 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 17, 01:00pm					Las Vegas Raiders LV Buffalo Bills BUF	Spread	Las Vegas Raiders LV	+8 -110

The Bills head into their home opener coming off a Monday night road game against the Jets and Aaron Rodgers. This will be the second road game for Josh McDaniels and the Raiders. Sometimes, starting on the road is a positive for a team when it comes to eliminating distractions. And the Raiders have plenty. 

The Bills underperformed badly on the line last season, going 8-9-1 (including the playoffs), despite finishing 13-3 straight up as AFC East champs. Even worse, they were 3-6 as home favorites. This line is too steep. Just Cover, Baby!

Best Bet: Raiders +8 (-110) at DraftKings

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Green Bay Packers at Atlanta Falcons, 1 p.m. (FOX)

Game	Bet	Pick	Best Odds
Sunday Sep 17, 01:00pm					Green Bay Packers GB Atlanta Falcons ATL	Moneyline	Atlanta Falcons ATL	-115

The Packers are in rebuild mode. Expect Jordan Love to be a work in progress for several weeks this season. The Falcons overperformed against the spread last season (9-8), and went 3-2 as a home underdog. 

The NFC South is wide open this season. The Falcons have the options on offense and depth and strength on defense to make a run at the flag. These are must-win home games for any team that hopes to reach the playoffs. 

Best Bet: Falcons Moneyline (-105) at DraftKings

Seattle Seahawks at Detroit Lions, 1 p.m. (FOX)

Game	Bet	Pick	Best Odds
Sunday Sep 17, 01:00pm					Seattle Seahawks SEA Detroit Lions DET	Spread	Detroit Lions DET	-2.5 -110

The Lions will have an extended break after opening the season at Kansas City on Thursday in Week 1. Detroit has become everyone’s favorite longshot in the NFC. The Lions have been the King of The Jungle when it comes to covering the spread. 

Detroit has been .702 ATS during the past two seasons, the best in the NFL. The Lions are getting a discount here as 2-point home favorites. They were 3-1 as home favorites in 2022. Grab this number while you can. It will only be moving in one direction as kickoff approaches. 

Best Bet: Lions -2 (-110) at DraftKings

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Chicago Bears at Tampa Bay Buccaneers, 1 p.m. (FOX)

Game	Bet	Pick	Best Odds
Sunday Sep 17, 01:00pm					Chicago Bears CHI Tampa Bay Buccaneers TB	Spread	Chicago Bears CHI	-1 -110

The Buccaneers had Tom Brady and the worst record against the spread last season, finishing 4-13-1 on the line. Disaster all around for Bucs bettors. This season, Tampa Bay is just a 1.5-point home favorites in its home opener against the Bears. Baker Mayfield has been given the wheel of the Pirate Ship. 

Tampa Bay will be his fourth team in since 2021. Chicago QB Justin Fields enters his pivotal third season with the addition of D.J. Moore as a target, in addition to some much-needed help on the O-line. Grrr.

Best Bet: Bears -1.5 (-110) at DraftKings

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Kansas City Chiefs at Jacksonville Jaguars, 1 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 17, 01:00pm					Kansas City Chiefs KC Jacksonville Jaguars JAX	Moneyline	Jacksonville Jaguars JAX	+135

The Chiefs have 10 days off heading into this playoff rematch from last season. The Chiefs beat Jacksonville 27-20 in the AFC Divisional round. The Jaguars scored a backdoor over on the 9-point line at Kansas City. Kansas City opened as a 3-point favorite. Both teams should be fully acclimated to the new season. 

The difference here might be the weather. A 1 p.m. start in North Florida in mid-September could mean 92 degrees and humid, or the back door of a tropical storm. The Jaguars (+3) were 5-0 ATS as home cats, er dogs, last season. We like them to win outright. Duuuuuuvallll. 

Best Bet: Jaguars Moneyline (+130) DraftKings

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New York Giants at Arizona Cardinals, 4:05 p.m. (FOX)

Game	Bet	Pick	Best Odds
Sunday Sep 17, 04:05pm					New York Giants NYG Arizona Cardinals ARI	Spread	New York Giants NYG	-4 -110

The Giants head West to the Valley of the Sun in what will certainly sound like a home game for Big Blue. Expect a multitude of Giants fans in the stands at State Farm Stadium. The Cardinals are pegged for an NFL-worst 4.5 wins this year. Kyler Murray will likely miss at least half the season due to torn ACL suffered in Week 14. 

Drama reigns throughout the Cardinals organization. The Giants, meanwhile, are as dull as ever. Their over/under is 7.5 wins. They are all-in with Daniel Jones and our pick to win the NFC East. We’d like this line a lot better if it were 3 points and would consider a buy-down. 

Best Bet: Giants -4 (-110) at DraftKings

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San Francisco 49ers at LA Rams, 4:05 p.m. 

Game	Bet	Pick	Best Odds
Sunday Sep 17, 04:05pm					San Francisco 49ers SF Los Angeles Rams LAR	Spread	Los Angeles Rams LAR	+4.5 -110

The Rams should surprise on the upside this season. The 49ers won both matchups last season and scored easy covers on unreasonably tight lines (SF won 31-14 twice despite being a 1-point favorite in both games). 

San Francisco is the second-favorite out of the NFC but faces an uncertain situation at quarterback with Jimmy Garoppolo’s exodus to Sin City. Brock Purdy won’t surprise anyone, even at Levi Stadium South. The Rams were 3-1 last year as home underdogs, that covered 60% of their overall victories. Sean McVay isn’t done yet. 

Best Bet: LA Rams +4.5 (-110) at DraftKings

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Washington Commanders at Denver Broncos, 4:25 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 17, 04:25pm					Washington Commanders WAS Denver Broncos DEN	Spread	Denver Broncos DEN	-3.5 -110

Sean Payton and Russell Wilson should have gotten all the major mistakes out of their offensive system in Week 1 against Las Vegas. The Commanders afford them the opportunity to go full-throttle on what aims to be a major turnaround from last season’s tepid offense that generated an NFL-worst 16.9 points per game. 

The Commanders have made second-year passer Sam Howell their QB of the present and future. Howell had just one start last season, a win in a meaningless game against Dallas in Week 18. He’ll be tested by the Broncos defense and the Mile High crowd. Don’t horse around as this line will likely move in Denver’s favor as the game approaches. 

Best Bet: Broncos -3.5 (-110) at DraftKings

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New York Jets at Dallas Cowboys, 4:25 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 17, 04:25pm					New York Jets NYJ Dallas Cowboys DAL	Moneyline	New York Jets NYJ	+115

The CBS national game offers a familiar foe for Jets quarterback Aaron Rodgers – the Dallas Cowboys. The Jets and Cowboys are both primed for historic disappointments again this season. The Jets and Cowboys have gone 54 and 27 years respectively without winning a Super Bowl.

Rodgers has captured the hearts and minds of Jets bettors in Gotham and beyond, thrusting the Jets into the Super Bowl 58 conversation. Dallas ended Tom Brady’s career in the Wild Card Round in January before getting stumped by a rookie QB a week later. 

Some things never change. Rodgers has beaten the Cowboys 6 of the last 7 times he's faced them - including two last-second playoff wins with Green Bay. Ride with A-Rod in Big D.

Best Bet: Jets Moneyline (+110) at DraftKings

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Miami Dolphins at New England Patriots, 8:20 p.m. (NBC)

Game	Bet	Pick	Best Odds
Sunday Sep 17, 08:20pm					Miami Dolphins MIA New England Patriots NE	Spread	Miami Dolphins MIA	-2 -110

How this game snagged the Sunday Night spot in Week 2 is a mystery. Sure, the Patriots-Dolphins rivalry has produced plenty of drama over the decades. But New England is slotted for just 7.5 wins according to online sportsbooks, and Miami is just 2 wins better. These teams could well finish 2^nd and 3^rd in the AFC East. 

So what gives? Well, perhaps the NFL script writers have a surprise in store. Especially if Tua Tagovailoa is unable to play given his past injury concerns. If the Dolphins need a QB, they won’t be looking for Skylar Thompson to fill the void (Mike White, come on down). Miami swept this series straight up and ATS last year. And these teams took divergent paths this offseason. 

Best Bet: Dolphins -1 (-110) DraftKings

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Monday, September 18

New Orleans Saints at Carolina Panthers, 7:15 p.m. (ESPN)

Game	Bet	Pick	Best Odds
Monday Sep 18, 07:15pm					New Orleans Saints NO Carolina Panthers CAR	Spread	New Orleans Saints NO	-1 -110

This is the first game of the Monday Night doubleheader. An early-season NFC South matchup that – given how this division fell last season – could prove pivotal come playoff time. 

The Saints have a used Derek Carr at quarterback, while the Panthers have opted for a brand-new, fresh off the lot, version of Bryce Young. An interesting piece of betting data: The Saints and Panthers were 0-5 combined as road favorites and home underdogs respectively last season.

Best Bet: Saints -1 (+150) DraftKings

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Cleveland Browns at Pittsburgh Steelers, 8:15 p.m. (ABC)

Game	Bet	Pick	Best Odds
Monday Sep 18, 08:15pm					Cleveland Browns CLE Pittsburgh Steelers PIT	Spread	Cleveland Browns CLE	+1.5 -110

The Browns hope to have some stability at quarterback for the first time since they chose Baker Mayfield with the first pick of the NFL draft five years ago. 

Deshaun Watson is back for a full season and has a new offensive coordinator in veteran coach Bill Musgrave. Watson has immense potential. The Browns could surprise on the upside this season in this tough-as-nails division. It could start right here. 

Best Bet: Browns +1 (-110) DraftKings

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