One of the biggest games of Week 18 will feature the 49ers against the Rams in a huge divisional matchup. The Rams are not only playing for the division, but they are looking to jump up to the No. 2 seed in the NFC as they try to avoid the Packers in Round 2.

Meanwhile, the 49ers need a win to make the playoffs. If they lose this game, they would need losses by the Saints and Eagles to make the playoffs. But the Eagles will play on Saturday night, meaning the 49ers will already know if they need a win to get in. For that reason, this should be one of the more highly-contested battles of the week.

To get you ready for this NFC West matchup, here is everything you need to know from an NFL betting perspective along with our NFL picks going into Week 18.

Take a look at Rams vs 49ers odds, injury report, betting lines and more.

49ers vs Rams Matchups

49ers WR Deebo Samuel vs. Rams CB Jalen Ramsey: Samuel has totaled over 1,600 yards from scrimmage this season and is the most explosive weapon for the 49ers. Will Ramsey shadow him in Week 18?

49ers LT Trent Williams vs. Rams LB Von Miller: Williams is the best offensive tackle in the NFL and will see a lot of Miller off the edge on Sunday.

Rams WR Odell Beckham Jr. vs. 49ers CB Josh Norman: Beckham has already scored five touchdowns this season for the Rams. He is a good bet to get another against Norman and a rather weak secondary for the 49ers.

RELATED: NFL Week 18 Odds & Betting Lines For All Games

49ers vs. Rams Stats

27.3: The Rams are the No. 9 scoring offense in the NFL, averaging 27.3 PPG.

6-2: The 49ers are 6-2 ATS in their last eight games. They are also 6-2 SU in their last eight games.

5-0: The 49ers are 5-0 in their last five games against the Rams.

5-2: The Rams are 5-2 ATS in their last seven games against NFC West opponents.

114.3: Rams WR Cooper Kupp is averaging 114.3 receiving yards per game, the most in the NFL.

RELATED: NFL Week 18 Picks & Best Bets For Every Game

49ers vs. Rams Moneyline

The 49ers have had the number of Sean McVay and the Rams as of late, winning five straight games. But can they get another win on the road to make it to the playoffs? The answer is yes. They are the more desperate team and the running element of Trey Lance at quarterback makes them even more dangerous.

And with their defensive line and pass rush, the 49ers should be able to create a ton of pressure on Matthew Stafford, who has been in a slump over the last few weeks. At +170, the 49ers are a good bet on the moneyline this week on DraftKings. Look for them to win this game and to make it to the playoffs.

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49ers vs. Rams Point Spread

If the moneyline is too risky of a bet, consider taking the 49ers on the point spread. They are 4.5 point underdogs and everything about this game signals that it is going to come down to the last possession. The Rams have a tendency to keep games closer than they should. Just look at last week’s game against the Baltimore Ravens, which ended up being a one-point victory for the Rams.

This game is going to be close, so take the 49ers +4.5 (-110) on FanDuel. But as we mentioned above, don’t be surprised if the 49ers steal this game on the road in Los Angeles.

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49ers vs. Rams Totals

The total for this game sits at 44 points and that feels just about right. Both offenses have had their issues scoring points over the last month and with Lance likely starting once again, the 49ers will probably struggle to score more than 27 points. This game has all the makings of a 24-21 type of contest in which both teams lean on their run game and defense to take them home.

However, both offenses should be able to score into the 20s, making the over a smarter bet. Take the Over 44 (-110) on BetMGM, but don’t expect a ton of points to come from this contest.

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