It’s perennial powerhouse vs. red-hot upstart in the NFC Championship Game, as Brock Purdy and the San Francisco 49ers host Jared Goff and the Detroit Lions with a trip to the Super Bowl on the line. 

The Niners last went to the Super Bowl four seasons ago, though this is the third year in a row they’ll play in the NFC Championship. The Lions have never even been to a Super Bowl. It’s a huge bounceback season for a team that won three games just two seasons ago. 

The latest Lions vs. 49ers NFL odds show San Francisco favored by seven points, with an Over/Under at 51.5 points. Bookies.com veteran NFL handicapper Adam Thompson – who has hit on a whopping 62-64% of his NFL picks three years running, reveals his NFC Championship picks. 

Lions vs. 49ers Odds

Lions vs. 49ers Point Spread Pick

The Lions are 7-0 when gaining over 140 rushing yards and 7-5 when they don’t. The Niners have allowed over 135 just three times, and are 2-1 in those games. The Niners have also allowed just one 300-yard passer all year. Jared Goff’s QB rating is nearly 20 points lower on the road. 

This will be the toughest overall matchup for Detroit since facing the Ravens, a game they lost 38-6. A healthy Deebo Samuel makes the climb even tougher for Detroit. It’s the first major step for the Lions in their quest for glory, but this is the Niners’ season. Lock in the 49ers to cover the spread with the best odds at ESPN BET.  Elevate your wagering experience by betting at the best betting apps.

Lions vs. 49ers Over/Under Best Bets

This is a high total, and when the line is in the low 50s, the Under has hit in every instance involving either Detroit or San Francisco. But the Over is 6-1 against defenses allowing at least 25 ppg, as both are. 

Only one Lions game in the last four has gone over 50 points, and that was against the pass-defenseless Buccaneers. No Niners game in the last five weeks has finished over 45 points. In a season headlined by Unders, we’ll back another Under here. Get the best odds for the total at DraftKings. 

Lions vs. 49ers Moneyline Pick

The 49ers are -340 on the money line, so it would take a $340 wager to win $100 in profit on an SF victory. The Lions are at +270 (wager $100 to win $270). It’s a hefty price for the Niners, especially given the recent play of the underdog Lions. 

But Detroit has played outside just twice since Week 6, losing by 32 at Baltimore and by 15 at Chicago. Any game is winnable, and it would be argued Green Bay exposed the 49ers last weekend. But the road issues for Goff and the Lions as a whole aren’t worth a play. We’re sticking with other wagers on Sunday evening. 

Lions vs. 49ers Top Player Props

George Kittle, Over 58.5 Receiving Yards 

Odds: -114 at FanDuel

Kittle has been an off-and-on target for the Niners offense, but in two of the last three weeks he’s gained 126 and 81 yards, has at least 54 yards in nine of the last 11 games, and is averaging 80.5 ypg over that span. 

The Lions aren’t good at guarding anyone receiving passes, but they’re 25th vs. TEs (55.3 ypg) and have been especially susceptible to TEs who can stretch the field. Kittle fits that mold. He’ll get even more looks if Deebo Samuel is out or less than 100%. Lock in the best odds for the Kittle Over at FanDuel. 

David Montgomery, Under 43.5 Rushing Yards 

Odds: -115 at BetMGM

Montgomery has formed a potent 1-2 rushing punch with Jahmyr Gibbs for the Lions. But he hasn’t hit over 40 yards in the past three weeks, despite 10-plus carries in each game. Gibbs hasn’t been great at running the ball lately, either, and neither may find much action here against the Niners, who are allowing just 64.5 ypg rushing to RBs this season. Take the Under on Montgomery at BetMGM.