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Best College Football Picks & Parlays To Bet For Week 5

Dan Kilbridge for Bookies.com

Dan Kilbridge  | 8 mins

Best College Football Picks & Parlays To Bet For Week 5

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Week 5 has arrived and it's already been a thrilling start for college football betting across the country.

The betting board is filled with key matchups as conference play is now well underway, including a top-25 SEC battle with No. 13 LSU traveling to No. 20 Ole Miss and No. 11 Notre Dame taking on No. 17 Duke in Durham.

We've included those two games and several others to construct a pair of Week 5 college football parlays. Make sure to use a trusted betting app!

Best College Football Parlays To Back Today For Week 5

Week 5 Parlay Legs Odds
Florida +1.5 over Kentucky-110
Texas A&M -6 over Arkansas-110
LSU -2.5 over Ole Miss-112
Parlay Odds +589 at DraftKings

Leg 1: Florida +1.5 over Kentucky

The Wildcats are 4-0 and have had the upper-hand in this matchup lately, with two straight wins over the Gators. They’ll have a tough time pulling off the hat trick against a Florida squad that was prematurely counted out after a Week 1 loss at Utah. This is already a battle-tested team, whereas the 4-0 Wildcats have been on auto pilot with four straight blowout wins over weak competition. 

This is a nasty Gators defense and we don’t think Kentucky is built to take advantage. We’re on Florida +1.5 to kickoff our first college football parlay featuring three SEC games.

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Leg 2: Texas A&M -6 over Arkansas

Arkansas didn’t catch any breaks over the last two weeks in hard-fought losses to BYU and LSU. Now the Razorbacks are dogs again and looking to avoid a third straight loss as they take on Texas A&M at AT&T Stadium in Dallas. 

A&M is coming off an impressive showing in a 27-10 win over Auburn and the defense has been dialed in all season. The Razorbacks are a tricky, tough opponent, but morale is low and the Aggies will have the upper-hand in the passing game. We’re on Texas A&M -6 for the second leg of our college football parlay in Week 5. 

Leg 3: LSU -2.5 over Ole Miss

The Tigers’ season is completely back on track after two straight wins over Mississippi State and Arkansas. The Week 1 loss to Florida State is already a distant memory and quarterback Jayden Daniels is a sneaky Heisman contender. 

This is one of the few offenses in the conference with enough pieces to keep pace with the Rebels offensively, and the Tigers have a great blueprint after seeing Alabama hold Ole Miss to just 10 points a week ago. We’re on the Bayou Bengals -2.5 to cap our first college football parlay .

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College Football Week 5 Parlay Bet No. 2

Week 5 Parlay Legs Odds
Colorado +21.5 over USC-110
Syracuse +6.5 over Clemson-110
Duke +5.5 over Notre Ddame-110
Parlay Odds +595 at DraftKings

Leg 1: Colorado +21.5 over USC

The doubters finally had a chance to take their shots at Colorado over the weekend, with the Buffaloes suffering their first loss of the season in blowout fashion against Oregon. We wouldn’t count on another one this week. It’s clear this Colorado team will struggle against elite defenses, but the Trojans are gettable in the secondary and haven’t been tested at all this season. 

This is gonna be a back-and-forth fireworks show, with the Buffaloes hanging in long enough to get a cover. We’re on Colorado +21.5 to begin our second college football parlay featuring three home underdogs. 

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Leg 2: Syracuse +6.5 over Clemson

Syracuse coach Dino Babers began the season on the hot seat, but the narrative is changing quickly after a 4-0 start for the Orange. We’ve seen an excellent defensive effort and a balanced offensive attack that could have the Orange challenging the top dogs in the ACC, starting with a Clemson team that owns five straight wins over Syracuse. 

The Orange have got them right where they want them at the JMA Wireless Dome and this looks like an even matchup on paper. We wouldn’t be surprised to see Syracuse pull off the upset, and we’re on the Orange +6.5 for the second leg of this college football parlay. .

Leg 3: Duke +5.5 over Notre Dame

The Irish suffered a heartbreaking home loss last week and now face a thankless task at Duke. The Blue Devils are done being a punching bag and this team doesn’t look any fun to play, with an excellent defense and toughness on both sides of the line. 

Notre Dame is still looking to find the sweet spot on offense and this is shaping up like another game where every possession matters and third-and-long conversions will be very hard to come by. Irish QB Sam Hartman will have his work cut out for him again against a Blue Devils secondary that’s only allowing 143.3 passing yards per game. This one could come down to the wire. We’re on Duke +5.5. 

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About the Author

Dan Kilbridge for Bookies.com
Dan Kilbridge
Handicapper Dan Kilbridge writes about college football, MLB and other sports for Bookies.com after spending three years covering Tiger Woods’ comeback and the PGA for Golfweek.