Week 5 College Football Best Bets: It Just Means More

Our Week 5 College Football Best Bets just mean more. The SEC offers several key games that will factor into determining which 2 teams will be playing for the conference championship in Atlanta.

Meanwhile, the Big Ten flexes with potential conference and national championship preview. The Oregon Ducks flock to Happy Valley for a likely white-out game against Penn State.

Three SEC games pit ranked teams against each other as the final weekend of September thrusts us into the cauldron of the college football season.

CBS long rues the day it failed to lock up the SEC 3:30 p.m. Saturday slot. This week provides another bittersweet reminder.

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Key SEC Clashes Could Impact Playoff Picture

Georgia and Alabama tussle between the hedges in Athens. These schools have won 7 of the past 8 SEC championship games. The Bulldogs clawed their way out of Knoxville 41-40 in Week 3. The Tide needs to right the ship under Kalen DeBoer. A win between the hedges would cool off his coaching hot seat.

The LSU Tigers ride Mike the Tiger into Oxford, where the host team remains undefeated during party time in the Grove. Brian Kelly has yet to fulfil the promise he brought to Baton Rouge. This year, things may finally break his way

Lane Kiffin has yet to break through the iron atop the conference. But he’s been made for games such as this. And no one is more dangerous to SEC teams looking for a clear path to the title game than Kiffin and the Rebels at home.

In the other SEC game between ranked teams among our Week 5 College Football Best Bets, Auburn visits Kyle Field to face Texas A&M and the 12th Man, offering an exciting opportunity for sports betting.

Other games of note include:

  • Ohio State begins it Big Ten run at Washington
  • 7 Big 12 matchups

Week 5 College Football Best Bets

Here are our Week 5 College Football Best Bets to back on the best sports betting sites

Week 5 College Best Bets

DateGameBest BetSportsbook
Fri., Sept. 26
Florida State Seminoles logo Florida State Virginia Cavaliers logo Virginia
TBDTBD
Fri., Sept. 26
TCU Horned Frogs logo TCU Arizona State Sun Devils logo Arizona State
TBDTBD
Fri., Sept. 26
Houston Cougars logo Houston Oregon State Beavers logo Oregon State
TBDTBD
Sat., Sept. 27
Ohio State Buckeyes logo Ohio State Washington Huskies logo Washington
TBDTBD
Sat., Sept. 27
USC Trojans logo USC Illinois Fighting Illini logo Illinois
TBDTBD
Sat., Sept. 27
Indiana Hoosiers logo Indiana Iowa Hawkeyes logo Iowa
TBDTBD
Sat., Sept. 27
Georgia Tech Yellow Jackets logo Georgia Tech Wake Forest Demon Deacons logo Wake Forest
TBDTBD
Sat., Sept. 27
Notre Dame Fighting Irish logo Notre Dame Arkansas Razorbacks logo Arkansas
TBDTBD
Sat., Sept. 27
Cincinnati Bearcats logo Cincinnati Kansas Jayhawks logo Kansas
TBDTBD
Sat., Sept. 27
UCF Knights logo UCF Kansas State Wildcats logo Kansas State
TBDTBD
Sat., Sept. 27
LSU Tigers logo LSU Ole Miss Rebels logo Ole Miss
TBDTBD
Sat., Sept. 27
Auburn Tigers logo Auburn Texas A&M Aggies logo Texas A&M
TBDTBD
Sat., Sept. 27
Utah Utes logo Utah West Virginia Mountaineers logo West Virginia
TBDTBD
Sat., Sept. 27
Baylor Bears logo Baylor Oklahoma State Cowboys logo Oklahoma State
TBDTBD
Sat., Sept. 27
Tennessee Volunteers logo Tennessee Mississippi State Bulldogs logo Mississippi State
TBDTBD
Sat., Sept. 27
Arizona Wildcats logo Arizona Iowa State Cyclones logo Iowa State
TBDTBD
Sat., Sept. 27
Oregon Ducks logo Oregon Penn State Nittany Lions logo Penn State
TBDTBD
Sat., Sept. 27
Alabama Crimson Tide logo Alabama Georgia Bulldogs logo Georgia
TBDTBD
Sat., Sept. 27
BYU Cougars logo BYU Colorado Buffaloes logo Colorado
TBDTBD
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Week 5 College Football Best Bets: Game-By-Game Analysis

Friday, September 26

Florida State at Virginia, 7 p.m. (FOX)

Buzz: FSU coach Mike Norvell spent 2024 in the coaching hot seat. This year, Virginia coach Tony Elliott occupies the hot spot. The Noles’ turnaround continues with authority at Scott Stadium.

Best Bet: TBD DraftKings via OddsJam  


TCU at Arizona State, 9 p.m. (FOX)

Buzz: The Sun Devils, unfortunately, can only go down this season in the Big 12 after their appearance in the College Football Playoff. This time, it’s TCU’s turn to surprise the prognosticators in their Big 12 opener.  

Best Bet: TBD DraftKings via OddsJam  


Houston at Oregon State, 10:30 p.m. (FOX)

Buzz: The Cougars tear up one more out-of-conference patsy before their Big 12 schedule begins in earnest.

Best Bet: TBD DraftKings via OddsJam  


The Georgia Bulldogs aim to put a bite on Alabama between the hedges this week. (USA TODAY)
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Saturday, September 27

Ohio State at Washington TBD (CBS)

Buzz: The defending national and Big Ten champions begin conference play out west in the Big Ten opener for both teams. The Buckeyes should flex early, but keep an eye on just how big a number they face.

Best Bet: TBD DraftKings via OddsJam  


USC at Illinois TBD (FOX)

Buzz: The Trojans gave the Big Ten West Coast contingent an early-season boost. But their conference schedule continues with a trip to Illinois. The Illini remain a sneaky good play.

Best Bet: TBD DraftKings via OddsJam  


Indiana at Iowa TBD (Peacock)

Buzz: Indiana ran off 10 straight victories to begin last season, posting one of the best overall records ATS among all FBS schools. We’ll see if oddsmakers have continued to discount the Hoosiers this week at Iowa in our Week 5 College Football Best Bets.

Best Bet: TBD DraftKings via OddsJam  


Georgia Tech at Wake Forest Noon (TBD)

Buzz: QB Haynes King and the Yellowjackets created plenty of buzz with their one-point win over Clemson. Look for a much larger stinger this week.

Best Bet: TBD DraftKings via OddsJam  


Notre Dame at Arkansas, 12 p.m. (ABC)

Buzz: Any other school would be long out of the Top 25 and the national championship conversation after an 0-2 start against the only ranked opponents on their schedule. But voters and networks grade Notre Dame on a much lower curve. If the Irish run the table against its next 10 foes (all unranked), they’ll get plenty of sympathy votes when playoff time comes.

Best Bet: TBD DraftKings via OddsJam  


Cincinnati at Kansas, 12 p.m. (TNT)

Buzz:  Cincinnati begin its Big 12 schedule coming off a bye and a 70-0 win over Northwestern State. Bearcats QB Brendan Sorsby faces a quantum upgrade on defense this week. The Jayhawks bring balance on both sides. They remain a tough out at home.

Best Bet: TBD DraftKings via OddsJam  


UCF at Kansas State, 12 p.m. (FS1)

Buzz:  A major letdown awaits UCF this week in Manhattan after basking in the national spotlight and Bill Belichick’s shadow at home in Week 4.

Best Bet: TBD DraftKings via OddsJam  


LSU at Ole Miss, 3:30 p.m. (FS1)

Buzz:  The LSU Tigers and Mike the Tiger stroll into The Grove, where the home team remains undefeated – at least during the pregame tailgate. Both coaches have yet to crack the SEC Brass Ceiling. Brian Kelly may have his best LSU team year. But no one is more dangerous to SEC teams looking for a clear path to the title game than Lane Kiffin and the Rebels at home. Just ask Nick Saban and Katy Perry.

Best Bet: TBD DraftKings via OddsJam  


Auburn at Texas A&M, 3:30 p.m. (ESPN)

Buzz:  Can Jackson Arnold and the Auburn offense make 102,733 vociferous “12th Men” shut up at Kyle Field? Texas A&M won its “Game of the Year” thanks to a 1-point victory over Notre Dame in South Bend. They come off the bye here. Meanwhile, Auburn comes to College Station fresh off a game at Oklahoma.

 Best Bet: TBD DraftKings via OddsJam  


Utah at West Virginia, 3:30 p.m. (ESPN)

Buzz:  The Utes head to Morgantown after their Big 12 opener against Texas Tech in our Week 5 College Football Best Bets. A road conference win in the Eastern Time Zone would give Utah instant Top 20 credibility. Coach Rich Rodriguez and the Mountaineers continue to amaze on the upside and downside this season.

Best Bet: TBD DraftKings via OddsJam  


Baylor at Oklahoma State, 3:30 p.m. (ESPN2)

Buzz:  Will this be the last roundup for Mike Gundy as coach of the Cowboys? Or does OSU poke the Bear(s)?

Best Bet: TBD DraftKings via OddsJam  


Tennessee at Mississippi State, 4:15 p.m. (SEC Network)

Buzz:  Any game is scheduled to kick at 4:15 p.m. on the SEC Network already smells like a lukewarm, 4-day-old, tuna-salad sandwich. The Vols scored 40 in losing by a point in OT to the Georgia Bulldogs. UT coach Josh Heupel and the Vols get these Bulldogs to heel with ease.

Best Bet: TBD DraftKings via OddsJam  


Arizona at Iowa State, 7 p.m. (ESPN)

Buzz:  The most-compelling Big 12 matchup of the week. Both teams come off the bye, and hold a combined record of 7-0. Arizona coach Brent Brennan wants to keep the ball on the ground and try to crack the Cyclones’ stout defense. The Wildcats can make a monster statement with a road win.

Best Bet: TBD DraftKings via OddsJam  


Oregon at Penn State, 7:30 p.m. (NBC)

Buzz:  The biggest Big Ten game of the year that doesn’t include Ohio State or Michigan is a highlight in our Week 5 College Football Best Bets. The co-main event features two unbeaten top-five teams. A potential conference championship preview? College football playoff preview? Or national championship preview? Perhaps one, two, or all the above. James Franklin often finds a way to wither in the heat of the national spotlight. This season carries a different vibe Happy Valley. 

Best Bet: TBD DraftKings via OddsJam  


Alabama at Georgia, 7:30 p.m. (NBC)

Buzz:  Alabama and Georgia have won the past 6 SEC titles, and 7 of the past 8. Georgia has ascended to the SEC Throne. And Kirby Smart, not Kalen DeBoer, stands as the legitimate heir to Nick Saban. Georgia held off Alabama last year at Athens in a wild 41-34 shoot out. But ex-Alabama QB Jalen Milrose rides the NFL bench in Seattle. And former Georgia QB Carson Beck lives “La Vida Loca” in South Beach. Both teams aren’t quite what they used to be. DeBoer can quite the restless Crimson masses with a road upset. But the Dawgs are too deep, too talented and too “Smart” to let that happen. 

Best Bet: TBD DraftKings via OddsJam  


BYU at Colorado, 10:15 p.m. (ESPN)

Buzz:  No better way to close a stacked Saturday of watching and wagering than to watch Coach Prime and the bad-boy Buffs take on BYU. No caffeine allowed.

Best Bet: TBD DraftKings via OddsJam  

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