College Football Week 3 Best Bets: SEC Begins With Heavyweight Bout

By Bill Speros Sep 13th, 2025 11:04 AM EDT

Our Week 3 College Football Best Bets see the return of full-time Power 5 intra-conference play at the best sports betting apps.

The SEC wastes no time in offering a pair of games that could well impact the participants in the conference championship game. The Georgia Bulldogs jump paws-first into the SEC fray by visiting Knoxville. An orange-clad throng of 102,000+ fans at Neyland Stadium await the defending conference champs in a matchup of Top 25 teams.

Saturday night, the Florida Gators return to the REAL “Death Valley” to face LSU. Florida beat LSU last season in The Swamp. Both teams could well be in top 13 of the AP Poll come kickoff.

The SEC isn’t hiding this week. Texas A&M takes a rare trip above the Mason-Dixon line to play Notre Dame. Another loss should land the Irish in the Top 3 of every poll.

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Other Week 3 College Football Best Bets include:

• A full Big 12 & ACC menu
• Oregon starting its Big Ten defense against Northwestern
• Ohio State looking for a monster cover against Ohio

Week 3 College Football Best Bets

Here are our Week 3 College Football Best Bets to back on the best sports betting sites. 

Date	Matchup	Week 3 Best Bets
Sat. Sept. 13	Clemson at Georgia Tech	Georgia Tech +7.5 (-110) DraftKings
Sat. Sept. 13	Vanderbilt at South Carolina	South Carolina -8.5 (-110) DraftKings
Sat. Sept. 13	Arkansas at Ole Miss	Ole Miss -12.5 (-110) DraftKings
Sat. Sept. 13	Wisconsin at Alabama	Wisconsin +19.5 (-110) FanDuel
Sat. Sept. 13	Georgia at Tennessee	Tennessee +6.5 (-110) DraftKings
Sat. Sept. 13	Pittsburgh at West Virginia	West Virginia +2.5 (-110) DraftKings
Sat. Sept. 13	South Florida at Miami	Miami -18.5 (-110) DraftKings
Sat. Sept. 13	Florida at LSU	Florida +7 (-110) DraftKings

Week 3 College Football Best Bets: Game-By-Game Analysis

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Saturday, September 13

Wisconsin at Alabama, Noon (ABC)

Buzz: Alabama may legalize the lottery just to generate enough revenue to buy out Kalen DeBoer’s contract. (It would cost about $70 million.) One would think the Tide could score an easy win here against this Big Ten foe deep in Dixie. But it’s nearly impossible to envision Alabama covering a 19.5-point line against Marquette – which stopped playing football in 1960 – never mind Wisconsin.

Best Bet: Wisconsin +19.5 (-110) at DraftKings via OddsJam  

Clemson at Georgia Tech, Noon (ESPN)

Buzz: The Tigers would love to break out here and make a statement. But they barely beat Troy on Saturday. The Yellow Jackets remain a tough out at home. We locked the in at 7.5 points, but the number made a big move to 6.5 points after Clemson's scare on Saturday. =

Best Bet: Georgia Tech +7.5 (-110) at DraftKings via OddsJam  

Arkansas at Ole Miss, 7 p.m. (ESPN)

Buzz: The Hogs sat some key players against Arkansas State and still rolled to a 56-14 win. But a full pen of pigs won’t be enough to contain the Rebels. Especially on an SEC Saturday night in Oxford. The Lane Train won’t stop until it hits Atlanta in December. Point differential matters. Ole Miss was the latest victim of the Kroger Stadium point-spread curse, failing to cover against Kentucky. The Train gets back track Saturday for Ole Miss bettors. And this number has moved 2.5 points in their favor. Take it.

Best Bet: Ole Miss -10 (-110) at DraftKings via OddsJam  

Vanderbilt at South Carolina, 7:45 p.m. (SEC Network)

Buzz: The Commodores hit dry land in Columbia this week, and the home team scores a decisive win and cover on the big number. This number tightened after Saturday after opening at 8.5 points. We'll take it.

Best Bet: South Carolina -7.5 (-110) at DraftKings via OddsJam  

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Georgia at Tennessee, 3:30 p.m. (ABC)

Buzz: Tennessee hung a 72-burger on East Tennessee Saturday. Georgia took it easier on Austin Peay. This is when CBS really starts to feel the loss of the SEC. A Tennessee upset would put the Vols in the subject line of the playoff discussion. Georgia remains the closest program to a college football dynasty in this era. Asking the Dawgs to cover a 7-point line at Neyland Stadium is something else entirely.

Best Bet: Tennessee +7 (-110) at DraftKings via OddsJam  

Pittsburgh at West Virginia, 3:30 p.m. (ESPN)

Buzz: The Panthers woefully underachieved last season in part due to multiple injuries at key spots. Pat Narduzzi survived this offseason despite losing his final 6 games. Rich Rodriguez returned to Morgantown this season, and this is the sort of game that would re-ignite the magic he delivered some 18 years ago. He'd better get moving quickly after losing outright to Ohio 17-10. Rich Rod cooks up the upset to win outright.

Best Bet: West Virginia +4.5 (-110) at DraftKings via OddsJam  

South Florida at Miami, 4:30 p.m. (CW)

Buzz: The Bulls scored a stunning victory in The Swamp as 17-point Dogs Saturday. This week, it's a trip to Hard Rock Stadium as part of their in-state series against Florida’s other Power 5 teams. Miami flexes its muscle. Miami QB Carson Beck can catch the eye of Heisman voters with some big numbers. South Florida earned 2 points in terms of this line with their win over Florida Saturday. But the 'Canes are in another league this season.

Best Bet: Miami -16.5 (-110) at DraftKings via OddsJam  

Arkansas at Ole Miss, 7 p.m. (ESPN)

Buzz: The Hogs sat some key players against Arkansas State and still rolled to a 56-14 win. But a full pen of pigs won’t be enough to contain the Rebels. Especially on an SEC Saturday night in Oxford. The Lane Train won’t stop until it hits Atlanta in December. Point differential matters. Ole Miss was the latest victim of the Kroger Stadium point-spread curse, failing to cover against Kentucky. The Train gets back track Saturday for Ole Miss bettors. And this number has moved 2.5 points in their favor. Take it.

Best Bet: Ole Miss -10 (-110) at DraftKings via OddsJam  

Florida at LSU, 7:30 p.m. (ABC)

Buzz: LSU goes as far as its defense takes them this season. LSU QB Garrett Nussmeier owns the top spot in the Heisman betting market, but his passing numbers against Clemson were deceptive. More game-management than production. The Gators got their tails kicked at home by South Florida in Week 2. The "Fire Billy" chants continue to echo across The Swamp. Still, UF's defense chomps on to Mike’s hindquarter and hangs on for the cover in Death Valley.

Best Bet: Florida +9.5 (-110) at DraftKings via OddsJam  

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