NFL Week 5 Best Bets: Bills, Rams Offer Potential Super Bowl 61 Preview Monday Night
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Week 5 of the NFL Betting Season concludes Monday night with a potential Super Bowl 61 preview. The Buffalo Bills visit SoFi Stadium to face the Los Angeles Rams.
Week 6 begins Thursday night with another potential Super Bowl 61 preview: The Seattle Seahawks come off their oh-so-close loss to the 49ers at home and visit the Mile High City. The Broncos endured a messy 23-17 victory Sunday over the winless Chargers.
Nick Sirianni Coaching Hot Seat got elevated to "Nuclear Fusion" after the Eagles somehow allowed the Jaguars to run back a kickoff and set-up a game-winning 57-yard field goal in the span of 8 seconds.
Week 6 Games of Note: Jaguars Stay In The U.K.
The NFL continues its run of 9 international games, with its third-straight week in London. The Jaguars stick around to face the 1-4 Houston Texans.
Tom Brady makes the call on the Fox-mini National Game of Week, as the Bears visit Atlanta in the early slot Sunday.
CBS has the doubleheader this week. Jim Nantz and J.J. Watt nake the call as for CBS as the Chiefs (who come off the bye) get their licks against the woeful and winless Los Angeles Chargers. The other late game of choice sends the Bills to Sin City.
Expect Mrs. Travis Kelce to in her luxury box of choice cheering on her betrothed.
The Sunday night game sends the Cowboys to Green Back
Monday night, the 5-0 49ers play host to the Commanders.
The Bengals, Lions, Dolphins and 5-0 Vikings are on the bye.
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Week 6 NFL Best Bets: Game-By-Game Picks & Odds
NFL Week 6 Best Bets
Bookies.com Picks · FanDuel Odds Via OddsJam
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Week 5 NFL Best Bets: Game-By-Game Breakdown
Monday, October 12
Buffalo Bills at Los Angeles Rams, 8:15 p.m. (ABC)
Buzz: : The Rams and Bills remain the betting favorites to win the Super Bowl. The Rams (2-2, 2-2 ATS) have seen their defense hobbled without the injured Myles Garrett. Although Garrett wasn't missed as the Rame beat the Eagles 24-20 at Philly Sunday, rallying from a 10-point deficit. The Bills defense got exposed by Drake Maye, who engineered the second 4th-quarter comeback of his career in Buffalo's 29-26 loss. That formula lines up perfectly for Stafford & Company. Look for a nifty, high-scoring Monday night track meet inside SoFi Stadium.
Best Bet: Over 53.5 Points (-110) FanDuel via OddsJam
Week 6 NFL Best Bets: Game-By-Game Breakdown
Thursday, October 15
Seahawks at Broncos, 8:15 p.m. (Prime Video)
Buzz: The Seahawks came up a billionth of an inch short on their final play Sunday in a bruising 32-29 loss to the 49ers. The short week should be a blessing since Seattle must move on to Denver with no break. Seattle holds the edge on both sides of the ball. But the Seahawks turned it over four times Sunday. Just make sure those ghosts don't return for Sam Darnold at Mile High Whatever It's Called Stadium.
Best Bet: Seahawks -2.5 (-110) FanDuel via OddsJam
Sunday, October 18
Jacksonville Jaguars vs. Houston Texans, 9:30 a.m. (NFL Network)
Wembley Stadium (London)
Buzz: The NFL plays in London for the third consecutive week. The Jaguars, who pulled off a thrilling 19-17 win over the Eagles in London thanks to a last-second 57-yard field goal, stick around the U.K. for another week to face the Houston Texans. Oddsmakers caught up with the Jaguars in Week 5, as they failed to cover as 7.5-point favorites against an injury-decimated Eagles roster. This game opened with Jacksonville as a 3-point underdog last spring. That number has since pulled a 180. Houston got off the schneid Sunday with its first win of 2026. C.J. Stroud and the Texans — even with Marvin Harrison Jr. — don't carry enough octane to keep up with Jacksonville. The Jaguars are for real this season. They prove it again this week with the cover.
Best Bet: Jaguars -3 (-105) FanDuel via OddsJam
Chicago Bears at Atlanta Falcons, 9:30 a.m. (NFL Network)
Buzz: Not having Caleb Williams caught up with the Bears on Sunday, as they suffered a 31-7 beating at Lambeau Field. Reality and the Packers secondary caught up with Tyson Bagent, who threw a pair of interceptions. The Falcons end their reign of terror on national prime-time TV after three straight weeks. But this will still be the featured game on FOX. Bijan Robinson fans rejoice. The Bears opened as 1.5-point favorites, but that number flipped. That's a tell that oddsmakers remain unsure about Williams' return. The Falcons run the ball (181 rushing yards per game before Sunday night) and can stop the rush (allowing just 46.3 yards per game). Even with Williams, the Bears may not get the ball enough to keep pace here.
Best Bet: Falcons ML (-110) FanDuel via OddsJam
Baltimore Ravens at Cleveland Browns, 1 p.m. (FOX)
Buzz: The Ravens average 29.2 points per game, compared with just 18.6 for the Browns. Our model has the Ravens winning by six. QB Snoop Huntley led the Ravens to a thrilling OT win at Atlanta Sunday night (with lots of help from Derrick Henry). Baltimore brings the NFL's fourth-ranked offense into an AFC North showdown against a Cleveland team coming off a 17-12 loss to the Jets. The Deshaun Watson Comeback Tour stalled amid the remnants of Hurricane Isaias. The Browns defense delivers on the backdoor cover.
Best Bet: Browns +3.5 (-105) FanDuel via OddsJam
Tennessee Titans at Indianapolis Colts, 1 p.m. (FOX)
Buzz: The 0-5 Titans appear fully committed to winning the Jeremiah Smith Sweepstakes and the top pick in the NFL draft. QB Cam Ward managed just 170 passing yards against the previously winless Texans Sunday in a 26-3 loss. The Colts defense, meanwhile, continued to serve as a swinging door. In Pittsburgh, it transformed 2026 Aaron Rodgers into 2016 Aaron Rodgers. A-Rod threw for 235 yards and three TDs in Pittsburgh's 34-22 victory. This game features the NFL's worst offense in Tennessee (261.3 yards per game) against its No. 30 defense in Indianapolis (392.3 YPG). Tennessee's defense can keep this close, provided Ward & Co. limit the turnovers.
Best Bet: Titans +7 (-105) FanDuel via OddsJam
New York Jets at New England Patriots, 1 p.m. (CBS)
Buzz: Clark Kent must have stayed in Jacksonville. A week after upsetting Buffalo on the road, Drake Maye tore up the Raiders, accounting for five TDs in Sunday's 45-17 Old Testament whipping. This week's line opened at 9.5 points before tightening to seven Sunday night after the Jets' win and multiple injuries for the Patriots. This is still New England's (3-2, 3-1-1 ATS) largest spread this season. And a nod that oddsmakers expect both CB Christian Gonzalez and WR A.J. Brown back this week. The Jets sideswiped Deshaun Watson's Comeback Tour Sunday with a 17-12 win at MetLife amid the remnants of Hurricane Isaias. The likely loss of Patriots OL Will Campbell and RB TreVeyon Henderson gives the Jets' fierce defensive front hope here. If Maye's near-flawless play from the past two weeks continues, however, Gang Green will need Kryptonite.
Best Bet: Patriots -7 (-105) FanDuel via OddsJam
New Orleans Saints at New York Giants, 1 p.m. (FOX)
Buzz: The Giants were gifted a 27-27 tie thanks to the Commanders botching the final play of overtime. The Saints — losers of three straight — opened as 1.5-point favorites, but that line flipped Sunday night. Jameis Winston continues to not lose games, and the Giants' defense has kept the team in contention in the NFC (L)East. Led by quarterback Tyler Shough and big-play weapons like Alvin Kamara and Chris Olave, 1-5 New Orleans enters this matchup trying to fix its defensive issues, while Saints HC Kellen Moore looks to get ahead early with chunk plays rather than grind it out.
Best Bet: Under 45.5 Points (-110) FanDuel via OddsJam
Carolina Panthers at Philadelphia Eagles, 1 p.m. (FOX)
Buzz: The Eagles limp home from London down half a wing amid a three-game losing streak and a disastrous 19-17 loss to the Jaguars. Coach Nick Sirianni took the blame for Philly's demise in London Sunday. Bryce Young has the Panthers on the prowl, scoring 30.3 points and amassing 405.5 yards per game. What's left of the Eagles' offense won't be able to keep up. Our model calls for Carolina to win outright as a 1.5-point underdog. The bots rule.
Best Bet: Panthers ML (+102) FanDuel via OddsJam
Pittsburgh Steelers at Tampa Bay Buccaneers, 1 p.m. (CBS)
Buzz: The Bucs won their first game of 2026 Thursday night by beating Dallas. But their 2027 draft quest for C.J. Carr/Arch Manning/Trinidad Chambliss/Dante Moore resumes in earnest this week. Aaron Rodgers got his groove back Sunday against the Colts. Expect a home-away-home crowd for Pittsburgh at Raymond James Stadium. That matters as Bucs QB Jalon — not Jayden — Daniels has his hands full with the Steelers' defensive front seven, led by T.J. Watt. This number is a tell that oddsmakers don't expect Baker Mayfield to play this week. Our model has the Steelers winning by a touchdown. All hail our computer overlords.
Best Bet: Steelers -2.5 (+102) FanDuel via OddsJam
Arizona Cardinals at Los Angeles Rams, 4:05 p.m. (FOX)
Buzz: The Rams play Monday night at SoFi against the Bills. The Cardinals have dropped four straight, including Sunday's 45-21 home loss to Detroit. Arizona is allowing 32.4 points per game, and that spells trouble against Matthew Stafford and a Rams offense averaging an NFL-best 417 yards per game (before Monday). Even off a short week. The Cardinals can muster enough offense for a last-minute backdoor cover.
Best Bet: Cardinals +12.5 (+110) FanDuel via OddsJam
Los Angeles Chargers at Kansas City Chiefs, 4:25 p.m. (CBS)
Buzz: The Chiefs come off the bye and are back — both this week and this season. Jim Nantz returns to Arrowhead for the call. Expect Mrs. Kelce to be featured on the CBS telecast whenever her husband makes one of his four catches (season average). Patrick Mahomes has thrown 9 TD passes against just 2 picks, and Kenneth Walker III gives the Chiefs a bruising rushing attack with 132.3 yards per game. QB Justin Herbert remains under siege behind a battered offensive line, as injuries have decimated the 0-5 Chargers' receiving corps. LA's lack of offense has us leaning toward the under.
Best Bet: Under 43.5 Points (-110) FanDuel via OddsJam
Buffalo Bills at Las Vegas Raiders, 4:25 p.m. (CBS)
Buzz: The Bills and Rams played at SoFi Monday night. The Raiders got shredded by the Superman version of Drake Maye Sunday, giving up 45 points to an injury-decimated Patriots lineup. The Raiders, in the words of Dennis Green, "are who we thought they were." Josh Allen and the Bills offense has a terrific get-right opportunity in Sin City.
Best Bet: Bills -6 (-110) FanDuel via OddsJam
Dallas Cowboys at Green Bay Packers, 8:22 p.m. (NBC)
Buzz: The Cowboys left Jerry Jones pondering his life choices with their 24-16 loss to the previously winless Bucs. Dak Prescott & The 'Boys score 27.6 points per game, but Dallas' defense surrenders 27.2 points. Jordan Love and the Packers tore through the Bears at Lambeau Sunday. The Pack stacks points this week. But total of 52.5 points is straight out of the Big 12. Green Bay has lost DT Javon Hargrave and LB Edgerrin Cooper to major injuries in back-to-back weeks. But its defense makes the difference here.
Best Bet: Packers ML (-110) FanDuel via OddsJam
Monday, October 19
Washington Commanders at San Francisco 49ers, 8:15 p.m. (ABC)
Buzz: Jayden Daniels and the Commanders botched their chance for a potential game-winning field goal Sunday against the Giants and settled for a 27-27 tie. San Francisco survived a 32-29 heavyweight bout at Seattle in a game that featured seven turnovers. Injuries have returned to decimate the 49ers this season. But Brock Purdy still has a banged-up Mike Evans, George Kittle and CMC at his disposal. This game carries a 50-plus-point total, given that these teams combined for 59 points in Week 5. But the Commanders have yet to prove they can deliver on the road. Avoid the hook at 7.5 here and go with the under.
Best Bet: Under 50.5 Points (-110) FanDuel via OddsJam
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