NFL Week 3 Best Bets: Lions Visit Ravens In Super Bowl 60 Preview?

By Bill Speros Sep 5th, 2025 2:16 PM EDT

Lamar Jackson and the Ravens are among the Super Bowl favorites again this season. (USA TODAY)

Our NFL Week 3 Best Bets offer up a potential Super Bowl 60 matchup on Monday night.

Two of the league’s most frustrated fan bases tune into ESPN to watch the Detroit Lions visit the Baltimore Ravens. Both teams have flirted with Super Bowl berths in recent years. And they’ve absorbed big money in futures markets.

But both regressed last season in terms of playoff performance. Neither got out of the divisional round. The Lions got waxed at home by the Commanders. The Ravens could not escape the Bills in what was a regular-season rematch.

The Ravens and Bills are co-favorites to win the Super Bowl at DraftKings at +600. The Lions fell into the third tier at +1400.

A sneaky good playoff rematch slots in the 1 p.m. window as the Rams return to Lincoln Financial Field. The Eagles clipped the Rams in the Divisional Round last January in the cold and snow. The weather will be on LA’s side this time.

NFL Week 3 Best Bets Begin In Buffalo On Thursday

Our NFL Week 3 Best Bets begin with the Bills and Dolphins at Orchard Park, N.Y., on Thursday night. At 1 p.m. there are nine games in the early Sunday window. The Cowboys visit Chicago in the FOX national game at 4:25 p.m.

Patrick Mahomes, Taylor Swift and the Chiefs visit East Rutherford, N.J. for a meeting with Big Blue Sunday night on NBC.

Read on for our NFL Week 3 Best Bets to back on the best sports betting app.

2025-26 NFL Week 3 Best Bets: Odds & Picks

Date	Matchup	Week 3 Best Bets
Thur., Sept. 18	Miami Dolphins at Buffalo Bills	Miami +8.5 (-110) ESPN BET
Sun., Sept. 21	Indianapolis Colts at Tennessee Titans	Titans -1.5 (-110) ESPN BET
Sun., Sept. 21	Cincinnati Bengals at Minnesota Vikings	Vikings -1.5 (-110) ESPN BET
Sun., Sept. 21	Pittsburgh Steelers at New England Patriots	Under 43.5 Points (-110) ESPN BET
Sun., Sept. 21	LA Rams at Philadelphia Eagles	LA Rams +4.5 (-110) ESPN BET
Sun., Sept. 21	New York Jets at Tampa Bay Buccaneers	Buccaneers -7.5 (-110) ESPN BET
Sun., Sept. 21	Las Vegas Raiders at Washington Commanders	Under 47.5 Points (-110) ESPN BET
Sun., Sept. 21	Atlanta Falcons at Carolina Panthers	Panthers -1.5 (-110) ESPN BET
Sun., Sept. 21	Houston Texans at Jacksonville Jaguars	Jaguars +1.5 (-110) ESPN BET
Sun., Sept. 21	Denver Broncos at Los Angeles Chargers	Broncos ML (+105) DraftKings
Sun., Sept. 21	New Orleans Saints at Seattle Seahawks	Seahawks -7 (-110) ESPN BET
Sun., Sept. 21	Arizona Cardinals at San Francisco 49ers	49ers -3.5 (-110) ESPN BET
Sun., Sept. 21	Dallas Cowboys at Chicago Bears	Cowboys +3 (-110) ESPN BET
Sun., Sept. 21	Kansas City Chiefs at New York Giants	Chiefs -6.5 (-110) ESPN BET
Sun., Sept. 21	Detroit Lions at Baltimore Ravens	Under 49.5 Points (-110) DraftKings

2025-26 NFL Week 3 Best Bets: Odds & Picks

Thursday, September 18, 2025

Miami Dolphins at Buffalo Bills, 8:15 p.m. (Prime Video)

Buzz: Buffalo opened as 8.5-point favorites. Any number above 7 points is a tough ask in any intra-divisional game, especially his early in the season.

Best Bet: Miami +8.5 (-110) ESPN BET

Green Bay Packers at Cleveland Browns, 1 p.m. (FOX)

Buzz: This would have been a banger in 1965.

Best Bet: Under 43.5 (-110) ESPN BET

Indianapolis Colts at Tennessee Titans, 1 p.m. (CBS)

Buzz: We’ve already reached the point of the season when NFL Sunday Ticket seems like a waste. Cam Ward and the Titans score an early-season home win and cover.

Best Bet: Titans -1.5 (-110) at ESPN BET via OddsJam

Cincinnati Bengals at Minnesota Vikings, 1 p.m. (CBS)

Buzz: The day’s most intriguing game offers up 2 of the most underachieving-vs-expectations teams in the NFL. The Bengals offer nothing but frustration after slow start after slow start. The Vikings went 14-2 last season, got trashed in the first round of the postseason, and swapped in J.J. McCarthy at QB. Could he be the second coming of Joe Burrow?

Best Bet: Vikings -1.5 (-110) at ESPN BET via OddsJam

Pittsburgh Steelers at New England Patriots, 1 p.m. (CBS)

Buzz: The Patriots celebrate former coach Bill Parcells at halftime. In honor of The Tuna, these teams combine for 5 points as the Patriots win, 3-2.

Best Bet: Under 43.5 Points (-110) at ESPN BET via OddsJam

LA Rams at Philadelphia, 1 p.m. (FOX)

Buzz: The Rams fell short in the snow last season at Philly during the playoffs. LA fares better this time in the late summer climate. And the Eagles struggle to cover at home. (To wit: A 24-20 win over Dallas (+8.5) in the opener.) Hold your breath and ride with Matt Stafford.

Best Bet: LA Rams +4.5 (-110) at ESPN BET via OddsJam

New York Jets at Tampa Bay Buccaneers, 1 p.m. (FOX

Buzz: “Fire The Cannons!” Here comes the cannon fodder. Baker and the Boys will open it up on Gang Green.

Best Bet: Buccaneers -7.5 (-110) at ESPN BET via OddsJam

Las Vegas Raiders at Washington Commanders, 1 p.m. (FOX)

Buzz: The Raiders carry solid players up front but lack depth. The Commanders have the highest average roster age this season of all 32 NFL teams but are coming off the mini-bye and a Thursday night game. The opening line of Washington -7.5 points is too steep. The under stands as the safer play.  

Best Bet: Under 47.5 Points (-110) at ESPN BET via OddsJam

Atlanta Falcons at Carolina Panthers, 1 p.m. (FOX)

Buzz: Unfortunately, these teams play each other twice a year. There are leaves to be raked.

Best Bet: Panthers -1.5 (-110) at ESPN BET via OddsJam

Houston at Jacksonville, 1 p.m. (FOX)

Buzz: All 4 AFC South teams play each other this week. The winner here will hold serve early in the divisional race. It’s still September in Florida. That means heat and humidity, especially for the Texans, who are used to playing in a climate-controlled environment.  

Best Bet: Jaguars +1.5 (-110) at ESPN BET via OddsJam

Denver at Los Angeles Chargers, 4:05 p.m. (CBS)

Buzz: Sean Payton's defense delivers the road dog win, even without player bounties.

Best Bet: Broncos ML (+105) at DraftKings via OddsJam

New Orleans Saints at Seattle Seahawks, 4:05 p.m. (CBS)

Buzz: This one could be double digits by kickoff. Lock in Seattle at this number.

Best Bet: Seahawks -7 (-110) at ESPN BET via OddsJam

Arizona Cardinals at San Francisco 49ers, 4:15 p.m. (FOX)

Buzz: Oddsmakers have yet to board the 49ers Hype Train. The Cardinals over-performed on the line last season. But their discount has faded in 2025. It's been shifted here to San Francisco.

Best Bet: 49ers -3.5  (-110) at ESPN BET via OddsJam

Dallas Cowboys at Chicago Bears, 4:25 p.m. (FOX)

Buzz: The Cowboys defense kept Philly in check during Week 1 (with some help from Mother Nature) as Dallas scored a backdoor cover. This time, the Cowboys harass Caleb Williams, Dallas DC Matt Eberflus continues to torment Bears fans, and Dak spreads the wealth for the road upset. Tom Brady calls this one for FOX. He's impressed.

Best Bet: Cowboys +3  (-110) at ESPN BET via OddsJam

Kansas City Chiefs at New York Giants, 8:20 p.m. (NBC)

Buzz: Both versions of Taylor Swift’s “Welcome To New York” have amassed more than 425 million streams on Spotify. Her follow up - “Lost In East Rutherford” - has 127. The Chiefs finished underwater against the line last year by 6 games but went 12-0 straight up in one-score games. Take them here, but only if this number stays below 7.

Best Bet: Chiefs -6.5  (-110) at ESPN BET via OddsJam

Monday, September 22
Detroit Lions at Baltimore Ravens, 8:15 p.m. (ESPN)

Buzz: The NFL’s version of “Bridesmaids” features 2 teams that never return the love they get in preseason conference champion and Super Bowl markets. Still, this could be a Super Bowl 60 preview. The Lions own the best record of any NFL team ATS combined over the past 3 seasons. But it’s difficult to bite kneecaps on the road, outdoors, and in prime time. Lean into the under here.

Best Bet: Under 49.5 Points (-110) at DraftKings via OddsJam