NFL Week 4 Best Bets: Patrick Mahomes, Lamar Jackson Meet Again

By Bill Speros Sep 16th, 2025 12:39 PM EDT

Patrick Mahomes and Lamar Jackson meet again in Week 4.

Another showdown between Patrick Mahomes vs. Lamar Jackson highlights our NFL Week 4 Best Bets.

This is the final week with a full NFL odds schedule until Thanksgiving, thanks to the bye.

Both the Kansas City Chiefs and Baltimore Ravens lost their openers. The teams continue to face questions about their defense, even though they’re led by 2 of the top QBs in the game.

They meet at Arrowhead Stadium in the CBS national 4:25 p.m. time slot with Jim Nantz and Tony Romo making the call. Mahomes and Jackson could well find their groove in a game that screams over the final points total listed at the best sports betting sites, no matter how absurdly high it ends up being.

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NFL Week 4 Best Bets See Tom Brady Back In Tampa Bay

The NFL Week 4 Best Bets Monday Night Football nightcap offers a sneaky good AFC showdown in our NFL Week 4 Best Bets. Jake Browning the Bengals clash with our-defense-needs-to-carry-us Denver Broncos.

Elsewhere, the NFL Week 4 Best Bets schedule begins Thursday night with another Amazon Prime snoozer between the Arizona Cardinals and Seattle Seahawks. We’d like to see Pete (Kirk Herbstreit's dog) on the call for the second half.

The NFL resumes its overseas schedule with a 9:30 a.m. EST Sunday kickoff in Dublin, Ireland. The Steelers face the Minnesota Vikings as the “home” team on the Emerald Isle.

Seven games occupy the 1 p.m. EST Sunday timeslot in our NFL Week 4 Best Bets. Tom Brady makes his return to Tampa Bay to call the Eagles-Buccaneers game. Brady scored his final NFL career playoff victory as QB against the Eagles playing for the Bucs after the 2021 season.

Brady led the Bucs to their second Super Bowl trophy and his 7^th during the 2020 season.

Sunday night, Green Bay visits Dallas. The early Monday night game sends the Jets to Hard Rock Stadium to face the Dolphins, which you can wager on at the best sports betting apps.

NFL Week 4 Best Bets: Odds & Picks

WEEK 4

Date	Matchup	Week 4 Best Bets	Odds	Book
Thur., Sept. 25	Seattle Seahawks at Arizona Cardinals	TBD	TBD	TBD
Sun., Sept. 28	Minnesota Vikings at Pittsburgh Steelers	TBD	TBD	TBD
Sun., Sept. 28	New Orleans Saints at Buffalo Bills	TBD	TBD	TBD
Sun., Sept. 28	Tennessee Titans at Houston Texans	TBD	TBD	TBD
Sun., Sept. 28	Cleveland Browns at Detroit Lions	TBD	TBD	TBD
Sun., Sept. 28	Philadelphia Eagles at Tampa Bay Bucs	TBD	TBD	TBD
Sun., Sept. 28	Carolina Panthers at New England Patriots	TBD	TBD	TBD
Sun., Sept. 28	Los Angeles Chargers at New York Giants	TBD	TBD	TBD
Sun., Sept. 28	Jacksonville Jaguars at SF 49ers	TBD	TBD	TBD
Sun., Sept. 28	Indianapolis Colts at Los Angeles Rams	TBD	TBD	TBD
Sun., Sept. 28	Baltimore Ravens at Kansas City Chiefs	TBD	TBD	TBD
Sun., Sept. 28	Chicago Bears at Las Vegas Raiders	TBD	TBD	TBD
Sun., Sept. 28	Green Bay Packers at Dallas Cowboys	TBD	TBD	TBD
Mon., Sept. 29	New York Jets at Miami Dolphins	TBD	TBD	TBD
Mon., Sept. 29	Cincinnati Bengals at Denver Broncos	TBD	TBD	TBD

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NFL Week 4 Best Bets: Game-By-Game Breakdown

Thursday, Sept 25

Seattle Seahawks at Arizona Cardinals, 8:15 p.m. (Amazon Prime)

Buzz: Only Kirk Herbstreit's dog Pete can save this one. A dog to begin our NFL Week 4 Best Bets.

Pick: TBD

Sunday, Sept. 28

Minnesota Vikings vs. Pittsburgh Steelers, 9:30 a.m. (NFL Network)
at Dublin, Ireland

Buzz: Aaron Rodgers hits the Emerald Isle to face a familiar foe. He’s won 17 of his previous 30 starts against the Vikings (with one tie). We’ll see if A-Rod and the Steelers offense can be “magically delicious” against Brian Flores’ defense.

Pick: TBD

Washington Commanders at Atlanta Falcons 1 p.m. (CBS)

Buzz: QBs Jayden Daniels (Washington) and Michael Penix Jr. were taken in the QB-heavy first round of the 2024 NFL draft. The Commanders entered the year with the oldest average roster age in the NFL. That could be a concern later. A fast track at Mercedes Benz Stadium favors the Falcons.

Pick: TBD

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New Orleans Saints at Buffalo Bills 1 p.m. (CBS)

Buzz: This will carry the largest point spread of the games in our NFL Week 4 Best Bets.

Pick: TBD

Cleveland Browns at Detroit Lions, 1 p.m. (FOX)

Buzz: Combined, the Browns and Lions haven’t won a championship in 128 years. The Lions keep flirting with a possible Super Bowl berth. This has a serious “trap game” feel, especially if the line lands in double digits.

Pick: TBD

Carolina Panthers at New England Patriots, 1 p.m. (FOX)

Buzz: Drake Maye played at Carolina, but the Panthers are no longer an ACC fill-in. They may finally be on upward trajectory.

Pick: TBD

LA Chargers at New York Giants, 1 p.m. (CBS)

Buzz: Justin Herbert and Russell Wilson. Today's Brady vs. Manning.

Pick: TBD

Philadelphia Eagles at Tampa Bay Buccaneers, 1 p.m. (FOX)

Buzz: Tampa Tom makes his homecoming inside the FOX booth to add some juice to our NFL Week 4 Best Bets. He’ll call a game featuring 2 teams that have met in the postseason twice in the past 4 years. The Bucs won both.  Tampa Bay and Philly could well meet again this postseason. The Eagles should control the pace of this game on the offensive and defensive lines. 

Pick: TBD

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Tennessee Titans at Houston Texans, 1 p.m. (CBS)

Buzz: The Texans should score an easy win here against an AFC South opponent. But Houston isn’t built to cover any sort of crazy line here. If it’s over 7 points, grab the Titans.

Pick: TBD

Indianapolis Colts at LA Rams, 4:05 p.m. (FOX)

Buzz: Indiana Jones visits this week’s Temple of Doom.

Pick: TBD

Jacksonville Jaguars at San Francisco 49ers, 4:05 p.m. (FOX)

Buzz: The Mac Jones Revenge Tour gets a crack at one of his former teams when the 49ers play host to Jacksonville. It's a homecoming for Jones, so he knows the key to winning in the Florida sun is hydration.

Pick: TBD

Baltimore Ravens at Kansas City Chiefs, 4:25 p.m. (CBS)

Buzz: Park Avenue stacked several of KC’s marquee games early this season. That’s a tell it knew the Mahomes Magic might not continue this season. KC’s 0-2 start may prove it right. The Shield does not expect the Chiefs to maintain the magic that has captivated the NFL for the past 5 seasons. Except the Chiefs to be underdogs at home for the second time this season in our NFL Week 4 Best Bets.

Pick: TBD

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Chicago Bears at Dallas Cowboys, 8:20 p.m. (NBC)

Buzz: Two first-season coaches meet in prime time. Ben Johnson has yet to unleash Caleb Williams. The Cowboys and Brian Schottenheimer adjust to life after Micah Parsons.

Pick: TBD

Monday, September 29

New York Jets at Miami Dolphins, 7:15 p.m. (ESPN)

Buzz: Will Bill Belichick be coaching the Dolphins?

Pick: TBD

Cincinnati at Denver, 8:15 p.m. (ABC)

Buzz: Bengals QB Jake Browning makes his second start in place of Joe Burrow. The Broncos got thrown off their horse at Indy in Week 2. Denver’s defense may well be caught by surprise again here.

Pick: TBD

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