Panthers vs 49ers Odds, Best Bets & Player Props For MNF NFL Week 12

By Adam Thompson Nov 24th, 2025 12:17 PM EST

Carolina Panthers running back Rico Dowdle (5)

NFC contenders face off in a marquee Monday Night Football matchup, as Bryce Young and the Carolina Panthers visit Brock Purdy, Christian McCaffrey and the San Francisco 49ers.

The Panthers (6–5) look to keep their playoff hopes trending upward, while the 49ers (7–4) aim to tighten their grip on the NFC West with another primetime statement.

The latest Panthers vs. 49ers NFL Odds has San Francisco at –7.5, a line that’s held steady throughout the week. The Over/Under for total points is 49.5.

Bookies.com veteran NFL handicapper Adam Thompson – who has hit on a whopping 60.2% of his NFL picks five years running, reveals his plays for this Monday night showdown.

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Panthers vs 49ers Betting Predictions

Panthers vs 49ers Point Spread

The 49ers enter MNF as the stronger team on paper, but they haven’t been putting opponents away. Only one of their wins has come by more than a touchdown, and both sides of the ball have shown uneven stretches throughout the season.

Carolina, meanwhile, has consistently stepped up in tougher matchups and kept games within reach. With a big number on the board, take the Panthers on MNF to cover the spread.

Eagles vs. Packers Over/Under

The 49ers have topped 27 points in three of their last four games, but their defense has also given up steady production, allowing 20-plus in four straight. With both sides trading explosive plays lately, it’s no surprise that the Over has cashed in several recent 49ers matchups.

The Panthers have also seen scoring upticks, but their offense leans heavily on the run, which can slow overall pace. Both teams may keep the ball on the ground, and with San Francisco’s defense tightening in the red zone, which team actually takes control of the scoring pace is uncertain. We’ll lean toward the Under — but only as a light secondary play.

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Panthers vs 49ers Same Game Parlay

1.Anytime Touchdown Scorer – Rico Dowdle – 145: Rico Dowdle should benefit from favorable field position against a soft interior front, especially on early downs. With opponents vulnerable to the run and backups often tested in prime-time spots, he’s well-positioned to capitalize and find the end zone again.

2. Player Rushing Yards – Christian McCaffrey Over 69.5 – 131:

Christian McCaffrey remains central to San Francisco’s offense when playing at Levi's Stadium. He regularly surpasses this rushing threshold by maximizing open lanes created upfront. Opposing run defenses have struggled to contain him over multiple games this season due to his elusiveness after first contract touches are missed frequently by defenders trying to tackle him one-on-one situations where he thrives most often out wide rather than between tackles which helps escalate those numbers easily past posted lines.

3. Player Passing Yards – Bryce Young Under 207.5 – 113:

Bryce Young has consistently struggled to hit big passing numbers on the road, with multiple sub-200-yard outings highlighting his difficulties adjusting to new schemes and handling increased pressure. Protection issues, missed reads, and late-game drop-offs have all contributed to a steady trend toward the Under — a trend that remains the expectation heading into this West Coast matchup.

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