Week 6 College Football Best Bets: Ghosts Of Wide Right Return

By Bill Speros Sep 26th, 2025 10:47 AM EDT

Miami visits Florida State in a big-time ACC/Sunshine State showdown.

The main event in our Week 6 College Football Best Bets brings us to Tallahassee, Florida. There, Florida State and Miami resume their annual rivalry in a game that has the feel of an epic 20^th-century showdown between the schools.

This is the 70^th meeting between FSU and Miami, with the Canes holding a 36-33 lead. The winner secures Sunshine State bragging rights. And grabs the inside track for a spot in the ACC championship game.

In 4 of their previous meetings, Miami won a close game after the Seminoles missed a field goal attempt wide right. And in 2002, Miami preserved its then-undefeated season with a 28-27 victory after FSU’s kicker missed a last-second field goal attempt wide left.

Miami coach Mario Cristobal played for the Hurricanes when they won the infamous “Wide Right” games in 1991 and ’92.

Big Week In SEC, Big Ten & Big 12

Can his mojo continue against the Seminoles in Tallahassee?

That’s just one sports betting opportunity to take advantage of at the best sports betting sites this week in college football.

As always, wager responsibly.

In the Big Ten, Ohio State, and Penn State continue conference play in our Week 6 College Football Best Bets.

The SEC offers Texas at Florida, in what could be a trap game for the Longhorns, and Georgia comes off its game against Alabama with a home contest against Kentucky. Alabama and Vanderbilt meet in Tuscaloosa. A year ago, the Commodores won this game in Nashville, and their delirious fans carried the goal posts 2 miles down Broadway and tossed them in the Tennessee River.

A pair of ranked Big 12 teams also continue conference play. TCU plays host to Colorado, and Iowa State visits Cincinnati.

Week 6 College Football Best Bets

WEEK 6 COLLEGE BEST BETS

Date	Game	Best Bet	Odds
Fri., Oct. 3	West Virginia at BYU	TBD	TBD
Sat., Oct. 4	Kentucky at Georgia	Georgia	-20.5
Sat., Oct. 4	Iowa State at Cincinnati	TBD	TBD
Sat., Oct. 4	Wisconsin at Michigan	Wisconsin	+16.5
Sat., Oct. 4	Illinois at Purdue	TBD	TBD
Sat., Oct. 4	Clemson at North Carolina	Clemson	-13.5
Sat., Oct. 4	Kansas State at Baylor	TBD	TBD
Sat., Oct. 4	Oklahoma State at Arizona	TBD	TBD
Sat., Oct. 4	Penn State at UCLA	TBD	TBD
Sat., Oct. 4	Washington at Maryland	Maryland	+7.5
Sat., Oct. 4	Texas at Florida	Florida	+7.5
Sat., Oct. 4	Boise State at Notre Dame	Boise State	+16.5
Sat., Oct. 4	Vanderbilt at Alabama	Vanderbilt	+13.5
Sat., Oct. 4	Texas Tech at Houston	Houston	+8.5
Sat., Oct. 4	Minnesota at Ohio State	Ohio State	-21
Sat., Oct. 4	Miami at Florida State	Miami	-4
Sat., Oct. 4	Mississippi State at Texas A&M	Texas A&M	-13.5
Sat., Oct. 4	Colorado at TCU	TCU	-13.5

Odds & Predictions Subject To Change Until Kickoff

Week 6 College Football Best Bets: Game-By-Game Analysis

Friday, October 3

West Virginia at BYU, 10:30 p.m. (ESPN)

BUZZ: The Mountaineers aren’t built for these mountains. BYU pounces on multiple mistakes and opportunities.

Best Bet: TBD DraftKings via OddsJam  

Saturday, October 4
Kentucky at Georgia, 12 p.m. (ABC)

BUZZ: The Bulldogs won’t sweat this number, even though Kentucky can be a problem at times on 2+ score spreads. 

Best Bet: Georgia -20.5 (-110) DraftKings via OddsJam  

Iowa State at Cincinnati, 12 p.m. (ESPN2)

BUZZ: The Cyclones appear headed for a Big 12 title game appearance. And point differential matters in conference tie breakers. Don’t be swayed by the number here. Even on the road.  

Best Bet: TBD DraftKings via OddsJam  

Wisconsin at Michigan, 12 p.m. (FOX)

BUZZ: The highlight of this Week 6 College Football Best Bet will be Barstool Sports head honcho Dave Portnoy returning to the Michigan campus as part of the FOX Big Noon Kickoff crew. Even though Wisconsin coach Luke Fickell remains in the coaching hot seat, it’s hard to see a quasi-competitive Big Ten game being decided by 3 scores.   

Best Bet: Wisconsin +16.5 (-110) DraftKings via OddsJam  

Illinois at Purdue, 12 p.m. (Big Ten)

BUZZ: The Boilermakers grab a home upset.

Best Bet: TBD DraftKings via OddsJam  

Clemson at UNC, 12 p.m. (ESPN)

BUZZ: Bill Belichick’s transformation from NFL “Best Of All Time” to historic laughingstock continues. He and his squeeze were brilliantly mocked by UCF after the Knights beat UNC. Even with Clemson in free-fall and Dabo Swinney under siege, the Tigers stomp to a victory in a Week 6 College Football Best Bet best suited for “Cartoon Network"

Best Bet: Clemson -13.5 (-110) DraftKings via OddsJam  

Kansas State at Baylor, 12 p.m. (ESPN+)

BUZZ: The Bears send K-State into Big 12 hibernation.

Best Bet: TBD DraftKings via OddsJam  

Oklahoma State at Arizona, 2 p.m. (TNT)

BUZZ: The Pokes continue life after Mike Gundy. Arizona comes home after a visit to Ames.

Best Bet: TBD DraftKings via OddsJam  

Penn State at UCLA, 3:30 p.m. (CBS)

BUZZ: The Bruins have already fired their coach this season. Penn State recovers on the West Coast after its monstrous showdown with Oregon in Happy Valley.

Best Bet: TBD DraftKings via OddsJam  

Washington at Maryland, 3:30 p.m. (Big Ten Network)

BUZZ: The Terps surprised on the upside with a 4-0 start that included an impressive road win at Madison. Washington faces The Ohio State this week.

Best Bet: Maryland +7.5 (-110) DraftKings via OddsJam  

Texas at Florida, 3:30 p.m. (TBD)

BUZZ: The Gators continually find ways to stumble over themselves. Their defense, however, contends with any in the SEC, especially in The Swamp. But that offense and those turnovers. Yikes. Billy Napier’s status won’t shift from "on thin ice" until a marquee win this season. If Arch Manning and the Longhorns are going to trip on a road in a game they should win easily, this would be it. 

Best Bet: Florida +7.5 (-110) DraftKings via OddsJam  

Boise State at Notre Dame, 3:30 p.m. (NBC)

BUZZ: The Irish fell flat against their 2 ranked opponents this season, but will get their playoff berth if they run the table. This week, Boise State plays the cupcake. But not getting 16.5 points.

Best Bet: Boise State +16.5 (-110) DraftKings via OddsJam  

Vanderbilt at Alabama, 3:30 p.m. (TBD)

BUZZ: A pair of ranked SEC teams fight to stay alive in the conference championship derby in our Week 6 College Football Best Bets. Alabama and Vanderbilt meet in Tuscaloosa. A year ago, the Commodores won this game in Nashville, and their delirious fans carried the goal posts two miles down Broadway and tossed them into the Tennessee River. The goal posts inside Saban Field aren’t going anywhere this week. But Vandy gets the backdoor cover.

Best Bet: Vanderbilt +13.5 (-110) DraftKings via OddsJam  

Texas Tech at Houston, 7 p.m. (ESPN)

BUZZ: Leave it to Houston to detail Texas Tech’s road to a Big 12 championship game. Or at least grab the backdoor cover at home. The Red Raiders come off the bye and an impressive win over Utah. But the narrative in the Big 12 changes every week.

Best Bet: Houston +8.5 (-110) DraftKings via OddsJam  

Minnesota at Ohio State, 7:30 p.m. (NBC)

BUZZ: Big Ten Saturday Night takes a giant step back from Oregon at Penn State. Ohio State continues its Big Ten rampage. John Nestor and the Gophers’ defense can be stingy. But the Bucks overpower and pull away in the 2^nd half. Point differential against common opponents matters in these games when it comes to conference tiebreakers. Oregon plays Minnesota in November.

Best Bet: Ohio State -21 (-110) DraftKings via OddsJam  

Miami at Florida State, 7:30 p.m. (ABC)

BUZZ: In the words of the late, great, Keith Jackson, we’ve got a “humdinger” in Tallahassee this week. This one tops our Week 6 College Football Best Bets. The Canes and Seminoles meet for the 70^th time. This time it means more as both are ranked in the Top 10. The winner secures Sunshine State bragging rights. And grabs the inside track for a spot in the ACC championship game. In 4 of their previous meetings, Miami won a close game after the Seminoles missed a field goal attempt wide right. And in 2002, Miami preserved its then-undefeated season with a 28-27 victory after FSU’s kicker missed a last-second field goal attempt wide left. Miami’s ferocious front on both sides of the ball dominates here. They won’t leave this one up to the kickers. 

Best Bet: Miami -4 (-110) DraftKings via OddsJam  

Mississippi State at Texas A&M, 7:30 p.m. (SEC Network)

BUZZ: Texas A&M scored 40 or more points in its first three games, including a sweet upset of Notre Dame in South Bend. The Aggies play host to their second SEC opponent in 2 weeks after a game with Auburn. But the Bulldogs opened the season 4-0 ATS. This number would be much larger otherwise. Still, Texas A&M covers here.

Best Bet: Texas A&M -13.5 (-110) DraftKings via OddsJam  

Colorado at TCU, 7:30 p.m. (ESPN2)

BUZZ: The Buffaloes lack consistency this season and could fade in the Big 12. TCU takes its 3-0 record to Arizona State this week. The Horned Frogs flex at home here.

Best Bet: TCU -13.5 (-110) DraftKings via OddsJam  

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