49ers vs Seahawks Same Game Parlay Picks for NFL (Sep 7th, 2025)

Seattle Seahawks wide receiver Cody White (82) scores a touchdown
Jeff Hanisch-Imagn Images

Lumen Field rarely sees quiet scoreboards when the 49ers visit. On September 7th, the NFC West rivals meet again, and recent matchups have leaned heavily toward offense. San Francisco has produced at least three touchdowns in both of their last two meetings. Each of those contests also cleared the 40-point mark, suggesting another high-scoring affair is likely. The NFL schedule delivers this divisional clash with plenty of scoring potential. 

49ers vs Seahawks Same Game Parlay Picks (Sep 7th, 2025)

Pairing San Francisco’s team total with the overall points line creates a cohesive wager. The 49ers’ recent scoring output supports their side of the bet. Both teams have contributed to high totals in past meetings. These selections align with the offensive trends seen in this matchup. Combining them leverages correlated scoring patterns for this game.

Pick 1: Team Total – San Francisco 49ers Over 22.5 – -125

San Francisco’s offense has found success against Seattle, reaching the end zone at least three times in both recent meetings. Their playmakers have consistently broken through the Seahawks’ defense. The 49ers’ scheme creates mismatches, especially in the red zone. Seattle’s secondary has struggled to contain explosive plays in these matchups. With continuity at quarterback and skill positions, San Francisco is positioned to surpass 22.5 points again. The matchup history and current roster health both favor this outcome.

Pick 2: Total Points – Over 43.5 – -105

The last two games between these teams each finished above 40 total points, reflecting a pattern of offensive production. Both sides have shown the ability to move the ball and finish drives. Seattle’s home field often encourages aggressive play-calling, which can boost scoring. The 49ers’ recent form suggests they will contribute significantly to the total. Defensive lapses on both sides have led to big plays in past meetings. The trends point toward another contest exceeding 43.5 points.