The unbeaten San Francisco 49ers match up with the Cleveland Browns, who just put 50 points on the Baltimore Ravens, in an intriguing Monday Night Football showdown from Levi’s Stadium. The host Niners (3-0) rank in the top five in yards gained and allowed per game heading into Week 5 of the NFL season, but the Browns (2-2) have cruised to wins in their two road games and covered handily in each.

Let’s take a look at some of the best bets fans of NFL betting should consider:

Browns-49ers Best Bets

All odds current as of publication but subject to change.

PICK 1: Browns +3.5

San Francisco is undefeated and ranks high in both yards gained and yards allowed. But let’s take into consideration they’ve faced the Buccaneers, Bengals and Steelers so far. The Niners have failed to cover the spread in their last six games following a bye week. They’ve covered in just seven of the last 24 home games, too. The Browns are an appetizing choice based on those facets.

In addition, Cleveland scored 13 points in each of its home games but 23 and 40 in its two road wins. Baker Mayfield’s QB rating on the road (92.3) is better than Jimmy Garoppolo’s home split (82.4)

RELATED: Your complete Browns-49ers betting preview

Mayfield, for all his accolades and praise, has been one of the least clutch players in recent memory. He has committed a turnover in a ridiculous 14.3% of his fourth-quarter plays – Jameis Winston’s 7.3% clip is second-worst. And Mayfield's completion percentage of 41.2% when the game is considered “close and late” is atrocious.

Regardless of Mayfield’s lack of clutch, this has the markings of a close game. The points are much more appealing than a Browns moneyline pick.

PICK 2: Under 46.5 Points

The Under has hit in the last four meetings, but it’s also 5-2 in the 49ers’ last seven home games. In Browns games, the only times the Over hit this year is when one of the teams poured in 40-plus points.

The Under is 2-1 in 49ers games and coming off bye weeks, only once in the last six years has the total hit for more than 42 points. Two of the games it’s been under 25.

PICK 3: Highest-Scoring Quarter – Third Quarter

The Browns and 49ers pour on the points coming out of the break. San Francisco’s 12.7 ppg in the third quarter crushes everyone in the league. Cleveland’s 8.8 ppg in the third ranks third-highest and is well above any other 15-minute period for the team.

The third quarter often isn’t the top-scoring quarter so the odds are good to take a leap with these two teams on the field.

PICK 4: Highest-Scoring Half – Second Half

The 49ers’ top two-scoring quarters this season have been the third and fourth. They’re averaging a whopping 12.7 ppg in third quarters, tops in the NFL, and their 21 ppg in the second half leads the league, too.

CHECK OUT: Bookies.com NFL Week 5 Betting Power Rankings

Meanwhile, no team gives up more points in the fourth quarter than the Browns (11.5 ppg). Both teams score more points and allow more points in the second half.

PICK 5: First Score of Game – 49ers Field Foal

The Niners have no three-and-outs in the first quarter and Jimmy Garoppolo is averaging 11.8 yards per attempt in the first quarter, third-best in the NFL. But the Browns have allowed just six points in the opening quarter all season. Let’s see those two trends come together, ending with a Cleveland stop in the red zone and an opening three points for the Niners.