It doesn’t get much bigger in the NFL regular season than this Week 12 Sunday Night Football showdown. Jimmy Garoppolo and the 9-1 San Francisco 49ers play host to Aaron Rodgers and the 8-2 Green Bay Packers, a clash of the top two teams in the NFC.

The 49ers have covered the spread just once in their last four games, while the Packers are on a 5-1 ATS run on the road.

RELATED: Sunday Night Football Betting Preview: Packers At 49ers

Let’s take a look at some of the best bets fans of NFL betting should consider:

Packers-49ers Best Bets

OTHER BETS TO BACK

• Second Half | 49ers -0.5 +110 (William Hill)
• First TD | Packers +104 (888sport)
• Score First & Lose | Packers +280 (FanDuel)

All odds current as of publication but subject to change. Check out the latest Packers-49ers odds here.

PICK 1: 49ers -3

The 49ers rank No. 1 in the NFL against the pass (173.5 ypg) and lead the league in sacks. They’ll make things tough on Aaron Rodgers.

The Packers have bent but not broken much en route to an 8-2 record. But their defense ranks in the bottom 10 in the NFL in passing offense and passing defense and the offense. Green Bay has won just two of its last 11 games when underdog by three or more points.

PICK 2: Over 46 Points

The Over has been the trend in 49ers games, hitting in four straight, but this is the highest total in one of their games since Week 5.

The Packers’ defense has allowed a consistent 22-24 points in the last four games. The 49ers have managed between 20-24 in their three matchups with playoff contenders. Both offenses will put more-than-usual pressure on the defenses.

CHECK OUT: Bookies.com NFL Week 12 Betting Power Rankings

PICK 3: Second Half – 49ers -1.5

The Packers have been a first-half team, the 49ers a second-half team. San Francisco’s advantage after the break is more reliable. It has averaged 16.6 ppg after the break while allowing just 8.6. The Packers are nearly even.

PICK 4: First TD – Packers

Few teams get off to better starts than the Packers. In six of their 10 games they’ve scored at least seven points in the opening quarter, with 14 points three times. Seven of the 10 games they’ve scored the opening TD, too.

PICK 5: Score First & Lose – Packers

The Packers get off to great starts and the 49ers just win. Odds are favorable that both happen. The parlay boosts the payout.