The Cardinals were off in Week 12 on their bye, but are back to continue their quest to be the No. 1 seed in the NFC. Kyler Murray and DeAndre Hopkins are both expected to be back in the lineup after extended absences. How quickly can they get back into their elite level of play? That remains to be seen.

Meanwhile, the Bears are coming off a win on Thanksgiving with Andy Dalton at quarterback. Rookie Justin Fields may not play in this game due to fractured ribs. Can the Bears pull off the upset at home against arguably the best team in the NFL?

To get you ready for this NFC matchup, here is everything you need to know from an NFL betting perspective along with our NFL picks going into Week 13.

Take a look at Bears vs. Cardinals odds, injury report, betting lines and more.

Cardinals vs. Bears Key Matchups

Bears WR Darnell Mooney vs. Cardinals CB Marco Wilson: Mooney has posted back-to-back games with at least 120 yards. He’ll likely be the No. 1 receiver again on Sunday for Chicago with rookie Marco Wilson following him on the outside.

Cardinals WR DeAndre Hopkins vs. Bears CB Jaylon Johnson: Hopkins has not played since late October, but is expected to be back in Week 13. Johnson will likely draw the assignment as he has the size and length to match up with the All-Pro receiver.

Cardinals LT D.J. Humphries vs. Bears DE Robert Quinn: Quinn has been fantastic this season, totaling 11 sacks for the Bears. But will he be able to beat Humphries and take down Kyler Murray? It should be a fun battle to watch.

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Cardinals vs. Bears Stats

16.3: The Bears have the No. 29-ranked scoring offense in the NFL, scoring only 16.3 points per game.

18.4: The Cardinals have the No. 4-ranked scoring defense in the NFL, allowing only 18.4 points per game.

6-0: The Cardinals are 6-0 ATS in their last six road games.

1-5: The Bears are just 1-5 in their last six games straight up this season.

2-5: The Cardinals are just 2-5 straight up against the Bears in their last seven meetings.

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Cardinals vs. Bears Moneyline

The Cardinals are huge moneyline favorites in this game and it’s not really a surprise. They have the NFL’s best record and their franchise quarterback and All-Pro receiver are both returning to the lineup. Meanwhile, the Bears have major problems on offense and it’s not yet clear who will get the start at quarterback for them in Week 13.

Arizona has proven it's more than just a team led by Kyler Murray as it has won two road games with Colt McCoy over the last month. Don’t expect the Cardinals to slip up here, so take them at -350 on DraftKings as Arizona should be able to get its 10th win of the season in Chicago. New users can sign up for the BetMGM sportsbook with this BetMGM bonus code to receive a $1,000 risk-free bet. This could be a great week to use the promotion to ensure you aren't risking much of your own bankroll.

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Cardinals vs. Bears Point Spread

The Cardinals have been one of the league’s best road teams this season, as Arizona sports betting fans who've backed them can testify. In fact, they have not lost on the road yet this season and they are a perfect 6-0 ATS. That shouldn’t change this week as the Bears don’t have the offensive firepower to keep up with the Cardinals, especially with Murray returning to the lineup.

This is one of the bigger NFL spreads of the week, but you can make a case that it should be even higher as the Cardinals have a +108 point differential this season. Take the Cardinals -7.5 (-110) on FanDuel and expect Arizona to win this game by double digits.

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Cardinals vs. Bears Totals

We know how explosive the offense for the Cardinals has been this season. However, their defense has been equally as impressive. They are No. 4 in scoring defense this season, allowing only 18.4 points per game. They should have no problem slowing down Chicago’s makeshift offense on Sunday, especially if Andy Dalton is under center.

Take the Under 45.5 on BetMGM (-110) and expect the Bears to struggle to score 20 or more points in this contest. Make sure to check out your top sportsbooks in the US and best betting apps as this number does vary on different sportsbooks.

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