NFC West rivals face off for a third time, but the stakes are much higher this time as Matthew Stafford and the Los Angeles Rams host Kyler Murray and the Arizona Cardinals on Monday night in the opening round of the NFL Playoffs. The teams split their regular-season games, with each winning on the road.

This one is at Sofi Stadium in L.A., but the Cardinals are 8-1 on the road this season – the best record in the NFL – while the Rams are a modest 5-3 at home. Betting sites and betting apps have Los Angeles as a four-point favorite, with an Over/Under of 50 points in the latest Cardinals vs. Rams odds. When it comes to NFL spreads in this rubber match, the line has moved slightly toward Arizona, which opened at +4.5.

Take a look at Rams vs Cardinals odds, injury report, betting lines and more.

Cardinals vs. Rams Key Matchups

Tyler Higbee vs. Cardinals LBs: The Rams TE ranks No. 2 in receptions and No. 3 in yards and TDs. Arizona’s defense ranks in the NFL’s top four in fewest receptions, yards and TDs to the position. L.A. is 7-2 when Higbee has five or more receptions, and 3-3 when he doesn’t.

Kyler Murray vs. Rams Defense: The Rams have allowed the second-fewest passing TDs while collecting the third-most interceptions. Murray had two TDs and no INTs in Arizona’s win over L.A. this season and a 0/2 split in the loss.

Cooper Kupp vs. Cardinals DBs: Kupp had 13 receptions for 123 yards and a TD in L.A.’s 30-23 win over Arizona in Week 14, and just 5-64-0 in the Cardinals’ 37-20 win in Week 4. The Week 4 game was the only time Kupp has been held to under 95 yards.

RELATED: NFL Playoff Prop Bets: Most Passing, Rushing & Receiving Over Postseason

5 Key Cardinals vs. Rams Stats

1: Receiving TDs allowed to running backs by Arizona, the fewest in the NFL. Unfortunately that’s not a big part of the Rams’ pass game; they have just one such TD in the last 10 games.

.200: Win percentage by Kyler Murray against the Rams in his career (1-4). He’s passed for 325-plus yards against them twice, but both were in losses.

6: Rushing TDs allowed by the Cardinals all season, tied with the Patriots for the fewest in the NFL. Again, that’s not a huge key to the Rams’ success; they rank 30th in rush TDs.

13: Fumbles by Kyler Murray this season – but all 13 have been recovered by the Cardinals. The Rams have forced 1.2 fumbles per game but have recovered just 25% of them.

27: Receiving touchdowns allowed to WRs by the Cardinals defense, by far the most in the NFL. Conversely, the Rams have given up just 10 TDs to wideouts.

Cardinals vs. Rams Weather Forecast

It’s Los Angeles, so the skies are sunny and temperatures are temperate, even in mid-January. Monday’s high is posted for the mid-60s, with temps at kickoff expected to be around 60 degrees. No rain, no wind, and a roof over the stadium ensure a comfortable atmosphere for all the Cardinals fans as they descend onto L.A.

Cardinals vs Rams Player Props

Matthew Stafford, Over 1.5 TDs

Odds: -182 at FOX Bet

No team has allowed more touchdowns to receivers than the Cardinals. Stafford has tossed two-plus TDs in all but four games, including both vs. Arizona this season.

Matthew Stafford, Over 276.5 Passing Yards

Odds: -115 at DraftKings

Stafford had 287 and 280 yards in his two games vs. Arizona and has 277-plus in 12 of 17 games. The Cardinals rank sixth vs. the pass but allow 22 more yards on the road than at home.

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Odell Beckham Jr., Over 45.5 Receiving Yards

Odds: -114 at FanDuel

Arizona is the only team to hold Cooper Kupp to under 95 yards. Kupp will be the focus again and Beckham can be the WR to take advantage. In two games vs. the Cards he had 5-79 and 6-77.

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Cardinals vs. Rams Moneyline

The Rams are -180 favorites on the moneyline, meaning it would take a $180 wager to win $100 in profit. Conversely, underdog Arizona is +155 (a $100 bet means $155 in profit). Most sportsbooks are showing similar lines.

But the teams aren’t heading in the same trajectory as the postseason begins. Arizona sports betting fans were celebrating as the Cards opened the year 7-0 but they have since lost six of 10. The Rams had won five straight before falling in OT to the surging 49ers. On-field matchups favor the home Rams, too. But Kyler Murray has proved us wrong before. At L.A.’s price, we’re not backing it, but we’re not going with the Cardinals either.

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Cardinals vs. Rams Point Spread

The Rams are down to -4, from -4.5 at open. There are reasons to side with Arizona here – namely their success on the road. But we’re not wasting any time here, we're backing the Rams.

The Cardinals have outgained four of their last five opponents, but have just one win to show for it. Kyler Murray is 1-5 vs. the Rams and each loss has been by at least a TD. The L.A. run defense can make Arizona one-dimensional, and Matthew Stafford found success in both earlier matchups (280-plus yards in each, five total TDs). Arizona is just 1-8-1 ATS vs. L.A. in the last five years. Those looking for Monday night NFL betting action should consider laying the points with the home Rams.

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Cardinals vs. Rams Totals

The Over/Under for Monday Night Football sits at 50.5, the highest total of the week. It’s below the totals in the two games they’ve already played, which hit 53 and 57.

But both teams are wildly inconsistent on both sides of the ball. Four of the last seven Rams games have totaled 51 or more, the other three were 44, 39 and 30. The Cards' last three games averaged 42.3 before a 68-point game vs. Seattle in Week 18.

But we can focus on this series since Murray emerged. The last four he’s played vs. L.A. that he finished have all hit 53-plus and averaged 57.8. The Over looks to hold more value but we’ll put our bankroll on other NFL picks for Wild Card Weekend.

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