The 7-1 Arizona Cardinals finally fell from the ranks of the unbeaten. They went down at the hands of the 7-1 Green Bay Packers. The 3-4 San Francisco 49ers beat the woeful Chicago Bears. At home, they’ll have a chance to get back to .500 with a victory over the Cardinals on Sunday.

The 49ers are opening as the 1-point home underdog at NFL betting apps.

Check out the latest Cardinals vs. 49ers odds ahead of the matchup in Week 9.

Cardinals vs 49ers Key Matchups

Is Kyler Murray Playing? Cardinals QB Murray was seen limping noticeably as he left the field following their TNF loss to the Packers. Reports from NFL betting sites are suggesting he has a sprained ankle and could miss 1-3 weeks. If it’s Colt McCoy at QB for the Cards instead of the NFL MVP favorite, the entire betting market on this game changes.

Niners' Home Woes: Over a calendar year has passed since the 49ers won a game at Levi’s Stadium. Their last victory was on October 8, 2019, a decision over the Los Angeles Rams. The Cardinals are 5-1 straight up in their last six visits to San Francisco.

San Francisco Run Game vs Arizona Run Defense: The 49ers are averaging 123.7 yards per game on the ground. Arizona’s run defense is 26th in the NFL, allowing 120.1 yards per game. If the Niners can run the ball, they control the clock and keep Murray off the field.

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5 Key Cardinals vs 49ers Stats

0-3: San Francisco’s record since 2017 when coming into a game with a rest disadvantage. The Cardinals won’t have played since October 28 when they take the field Sunday. The Niners played on October 31.

4-0: Arizona’s road record this season.

0-7: The 49ers’ record in their past seven home games.

96: Number of touches by Cardinals RB Chase Edmonds prior to his first TD of the season in Week 8.

819: Receiving yards this season by 49ers WR Deebo Samuel, the most in franchise history through the first seven games of the season.

Cardinals vs 49ers Weather Forecast

The weather can be unpredictable in the Bay Area, and that could also be a factor if Murray attempts to play. Currently, the forecast for the 4:25 p.m. ET kickoff at Levi’s Stadium is calling for cloudy skies. There’s a 30% chance of precipitation. They’re also calling for 10 mph wind and a game-time temperature of 65 degrees.

Cardinals vs 49ers Player Props

Cardinals RB Chase Edmonds, Over 38.5 Yards Rushing

Odds: -115 at Caesars Sportsbook

Edmonds went over this total two of the past three games.

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49ers QB Jimmy Garoppolo, Over 220.5 Yards Passing

Odds: -115 at DraftKings Sportsbook

Garoppolo threw for a season-high 322 yards last week against the Bears.

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Cardinals RB James Conner, Over 37.5 Yards Rushing

Odds: -115 at Caesars Sportsbook

Conner is averaging 44.75 yards rushing per game.

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Cardinals vs 49ers Moneyline

Murray is an uncertain starter. There’s also concern about the status of WR DeAndre Hopkins (hamstring). Meanwhile, it’s a certainty that DE J.J. Watt (shoulder), Arizona’s best run defender, is done for the season. The 49ers can run the rock with rookie Elijah Mitchell, who’s had consecutive 100-yard games. If they move the ball on the ground, that means Jimmy Garoppolo won’t have to beat the Cardinals with his arm, and that’s always a bonus for the Niners.

San Francisco gave the Cards all they could handle in Arizona before falling 17-10. This game has upset written all over it. Play the 49ers in your NFL picks at -108.

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Cardinals vs 49ers Point Spread

The opening betting line on this game at sportsbooks in the NFL spreads was Arizona -2.5 points. The status of Murray is certainly the cause for the shortening of that line to Cardinals -1.

To the delight of Arizona sports betting fans, the Cardinals are 6-2 against the spread this season, while the 49ers are 2-5 ATS. San Fran is 1-6 ATS in the club’s past seven home games. The Cardinals are also 6-1-1 ATS in their last eight games against the Niners. Since we’ve already picked the 49ers on the moneyline, take the one point at DraftKings (-110) and bet San Francisco to cover.

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Cardinals vs 49ers Totals

Here’s an interesting little tidbit – last season, all eight Cardinals road games went under. Four of San Francisco’s last five games against NFC West Division rivals have also gone under. As well, the total has gone under in seven of Arizona’s last 10 games.

What we’re getting at here is that everything in the NFL betting line is suggesting that the wager to go with is the under on the total of 45 points. These two teams combined for a paltry 27 points in their first meeting this season. The under is absolutely the call on the total. You can get Under 45 (-110) at BetMGM.

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