The Arizona Cardinals are coming off their worst game of the NFL season. The Seattle Seahawks are looking to rebound from their first shutout loss in a decade. Whichever team gets it turned around the fastest will get a leg up as these two NFC West rivals meet in Week 11.

The Cardinals are set as 2.5-point road favorites in NFL betting markets at online sportsbooks.

Take a look at Cardinals vs. Seahawks odds, injury report, betting lines and more.

Cardinals vs Seahawks Key Matchups

Who’s Playing? Who’s Not?: Both teams are missing key pieces of their puzzle. Seahawks QB Russell Wilson (finger) came back last week but was unimpressive in a 17-0 loss to Green Bay. Cardinals QB Kyler Murray (ankle) will be a game-time decision. WR DeAndre Hopkins (hamstring) looks to be out.

Which Team Wins The Passing Battle?: In Wilson’s absence, Seattle’s passing attack dropped to 30th in the NFL. However, the Seahawks could get right facing Arizona’s 25th-ranked pass defense.

Cardinals vs. 12th Player: Seahawks fans are supposed to give them an edge. However, no visiting NFL team has won more games at Lumen Field than the Cardinals. They’re 5-4 there in the Wilson era.

RELATED: NFL Week 11 Odds & Betting Lines For All Games

5 Key Cardinals vs Seahawks Stats

39.4: Passer rating of Seahawks QB Wilson in his return last week from injury. That’s the fourth-lowest he’s posted in his career.

13.5: Number of sacks by Cardinals LB Chandler Jones against Seattle, the most he’s recorded against any team.

10: Number of consecutive 100-tackle seasons recorded by Seahawks LB Bobby Wagner.

12: TDs scored this season by James Conner. In Cardinals history, only Mal Kutner (13 in 1948) had more through the first 10 games of a season.

4: Total red zone interceptions thrown by Seattle QB Wilson since the start of the 2020 season. He was picked off four times in that scenario over the previous four seasons combined.

Cardinals vs Seahawks Weather Forecast

Perhaps the best news for the Cardinals as they head to the land of coffee and grunge music is that it’s only going to be gloomy on Sunday. In Seattle, that’s a win. Rain isn’t in the forecast. Cloudy skies, 2 mph wind and a temperature of 48 degrees will welcome the teams at Lumen Field.

Cardinals vs Seahawks Player Props

Seahawks WR D.K. Metcalf under 5.5 receptions

Odds: -125 at Caesars Sportsbook

A foot injury has slowed Metcalf in practice this week.

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Cardinals RB James Conner anytime TD

Odds: -120 at DraftKings Sportsbook

Conner has 12 TDs this season and at least one in each of the last four games and eight of the past nine.

Seahawks QB Russell Wilson over 20.5 rushing yards

Odds: -110 at DraftKings Sportsbook

Wilson carried the ball for 32 yards last week against Green Bay.

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RELATED: NFL Week 11 Picks & Best Bets For Every Game

Cardinals vs Seahawks Moneyline

Seattle simply hasn’t been able to display any consistency this season. While it’s easy to chalk that up to the loss of Wilson, the fact of the matter is that 8-2 Arizona has kept on rolling while dealing with a rash of injuries on both sides of the ball. The Cardinals bounced back strongly against an NFC West rival the other time they lost this season, whipping San Francisco without Murray.

Arizona has won three straight games overall from Seattle and the Cardinals are 4-2 in their last six visits to Lumen Field. The play on Arizona at NFL betting apps of -125 is worth the investment. You can get that price at DraftKings.

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Cardinals vs Seahawks Point Spread

As Arizona sports betting fans may know, the Cardinals are an impressive 7-3 against the spread this season. That includes a 1-0 slate ATS as a road favorite. As a road team this season in NFL spreads, Arizona is 5-0 against the spread and 5-0 overall. The Cardinals are also unbeaten ATS (1-0) on the road as 2+ point favorites.

As a home team this season, Seattle is 2-2 ATS and 1-3 straight up. The Seahawks are showing one win ATS (1-1) as 2+ point underdogs at home. The consistency of the Cardinals has to be taken into consideration here. Lay the points and go with Arizona. You can get Arizona -2.5 (-104) at FanDuel.

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Cardinals vs Seahawks Totals

The total for this game is set at 48 points by betting sites. In road games this year, the average score of Cardinals games is 50.1 points. When making NFL picks, note that the Cardinals are 5-5 on the total overall this season.

Arizona is the No. 4 NFL scoring offense at 28.7 points per game. Seattle is the No. 22 scoring offense, accumulating 20.1 ppg. Seattle is just 2-7 on the total. That includes just one over through four home games. Still, the Cardinals make the over the play to go with in this game. You can get Over 48 (-110) at PointsBet.