Best NFL Week 5 Parlays: Jared Goff, Kyler Murray & More

By Adam Thompson Oct 2nd, 2025 5:14 PM EDT

Detroit Lions quarterback Jared Goff (16)

Through four weeks of the 2025 NFL season, no team is a perfect 4-0 against the spread. In addition, no team has gone 0-4 against the number, either.

If that sounds odds, it’s because it is. The last time every team had covered at least once through four weeks, and failed to cover at least once, was 2010 – 15 years ago.

It’s only the third time in 35 years that no team has been unbeaten or winless ATS.

Six teams are 3-1 against the spread. Three of those teams – the Seattle Seahawks, Detroit Lions and Indianapolis Colts – are covering by an average of around 10 ppg.

On the flip side, the Cincinnati Bengals are 1-3, missing the number by an average of 14 ppg.

Bookies.com NFL handicapper Adam Thompson has his finger on the pulse of the NFL. Thompson has hit on a whopping 60.2% of his NFL best bets five years running and is at 63.3% so far for the 2025 NFL season. Here are his two NFL parlays to back on the best betting apps for Week 5 of the 2025 NFL season:

Intriguing NFL Week 5 Parlays

NFL Parlay	NFL Odds
Smackdown Hotel	+596 at BetMGM
Ground and Pound	+579 at Caesars

Odds are current as of publication but subject to change. For the most updated NFL odds, please check the betting apps.

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The “Smackdown Hotel” Parlay

Leg 1: Lions -10.5 over Bengals

This spread is going to go up, so get it now. The Bengals have the worst O-line in the NFL and can’t stop anyone on defense. They’ve been outscored 76-13 with Jake Browning under center. The lions have scored 34-plus in three straight games.

Leg 2: Cardinals -7.5 over Titans

The Cardinals’ offense has been struggling, but nothing compared to what Tennessee is enduring. The offense ranks 29th in rushing and 31st in passing and the team is giving up 33.3 ppg. Kyler Murray and Arizona have played in a lot of close games, now is the chance to not.

Leg 3: Colts -6.5 over Raiders

Daniel Jones leads the league in QBR, Jonathan Taylor is the top running back in the game right now, and the Colts defense is performing at a high level on all levels. The backdoor cover is always in play with risk-taking Geno Smith on the other side, but JT can chew the clock.

The “Ground and Pound” Parlay

Leg 1: Jahmyr Gibbs, over 77.5 Rushing Yards

The Lions RB has gained 94 and 91 yards in two of his team’s last three games, and 67 yards in the other. All three were blowout wins. This looks to be another rout vs. the Bengals, who are especially bad at getting to the RB at the line of scrimmage.

Leg 2: Javonte Williams, Over 69.5 Rushing Yards

The physical Cowboys RB has gained at least 76 yards in the last three games, averaging a robust 5.4 yards per attempt in that span. The Jets rank 27th in yards allowed after contact, so Williams, who bounces off guys as a living, has a chance to have another big day.

Leg 3: Daniel Jones, over 18.5 Rushing Yards

The Colts QB has finished in the mid-20s twice in four games, and can do so here against a Raiders defense that’s allowed the fourth-most run attempts to opposing signal-callers.

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About the Author

Adam Thompson

More About Adam

Long established as one of the nation's premier handicappers, Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine & CBSSports.com. He specializes in the NFL and MLB, where he's hit on well over 60% of his picks the past five years. Adam's NBA and horse racing picks have also produced consistent, major winners over the years.