Statistically, the Buffalo Bills are the best team in the NFL, leaders in both points scored and fewest points allowed. They’ll get a test on Monday Night Football in Week 6, as Josh Allen’s Bills head south to face Derrick Henry and the Tennessee Titans.

Henry is unchallenged as the NFL’s top RB, though he’ll get his biggest test against the third-ranked Buffalo run defense. Betting sites and betting apps have Buffalo as a 5.5-point favorite, with an Over/Under of 54 points in the latest Bills vs. Titans odds.

But does Monday offer NFL spreads worth backing?

Take a look at Bills vs Titans odds, injury report, betting lines and more.

Bills vs. Titans Key Matchups

Derrick Henry vs. Bills Run Defense: Henry is averaging 145.5 rushing yards over the last four games. Only once has an entire team rushed for more than 75 yards this season vs. the Bills.

Titans O-Line vs. Bills D-Front: The Titans have allowed the most sacks of any team in the NFL. The Bills’ front line ranks fifth in most sacks.

Josh Allen vs. Everyone: Allen is averaging 343 yards himself over the last three weeks. Tennessee allows 377 ypg overall.

RELATED: NFL Week 6 Odds For All Games On The Schedule

5 Key Bills vs. Titans Stats

0: Starts for RB Jeremy McNichols and WR Chester Rogers, who rank first and third on the Titans in receptions.

1: The NFL ranking in carries (142), rushing yards (640) and rushing TDs (7) for Titans RB Derrick Henry. Through five weeks, Henry leads those categories by 52, 117 and 2, respectively.

12.4: Yards rushing allowed to QBs by the Titans defense. Bills QB Josh Allen averages roughly triple that amount.

113: Yards allowed to tight ends by the Titans defense, the second-fewest in the league. Buffalo TE Dawson Knox had 117 receiving yards last Sunday vs. the Chiefs.

392: Yards allowed by the Bills defense last Sunday vs. the Chiefs, 102 more than any other game prior. The Titans have at least 368 yards in every game since Week 1.

Bills vs. Titans Weather Forecast

After a week full of temperatures in the 80s in Nashville, the city is expected to dip into the 60s and low 70s for the weekend and beyond. Monday’s high is a modest 72 degrees, with no clouds or wind expected. Gametime temps should be in the 60s, perhaps getting down to the 50s by the end.

Bills vs. Titans Player Props

Stefon Diggs, Over 82.5 Receiving Yards

Odds: -115 at FanDuel

No team has allowed more passing yards to receivers than the Titans. No Bills player has more targets than Diggs, who is getting nearly 10 looks per game. He’s hit over this mark just once all season but this is a good spot to do it again.

Bet $5, Get $200 in Bonus Bets

Tap for Promo Activated! Visit site

Used 39 Times Today

Josh Allen, Over 324.5 Total Yards

Odds: -115 at DraftKings

Allen has gone over this number three straight games and the Bills have scored at least 38 points in all three. Not only is the Titans’ defense highly suspect, its offense should do some scoring of their own, which means Allen keeps throwing and pressing the ball down the field. That means another productive night for the QB.

Bet $5, Get $200 in Bonus Bets + No Sweat SGP

Tap for Promo Activated! Visit site

Used 48 Times Today

Randy Bullock, Over 6.5 Points

Odds: -130 at BetMGM

We know Tennessee has the weapons to get the ball in the end zone. But Buffalo has the No. 1 red zone defense in the NFL, and the Titans’ red zone offense ranks 26th. It makes for a busy day for Bullock, the Titans’ kicker, who has scored at least eight points in every game.

Bet $10, Get $200 in Bonus Bets Instantly

Tap for Promo Activated! Visit site

Used 18 Times Today

Josh Allen More Pass Yards Than Ryan Tannehill

Odds: -240 at PointsBet

Tannehill has surpassed 212 yards passing just twice in five games, though his banged-up WR corps hasn’t helped. Still, the Titans run first. Allen throws more often and for more yards, and the pass defenses each faces here – Tennessee ranks 21st, Buffalo 2nd – offers another big edge.

Up To $1,000 in Second Chance Bets

Tap for Promo Activated! Visit site

Used 5 Times Today

Stefon Diggs Over 5.5 Receptions and Bills lead at halftime and fulltime

Odds: +125 at PointsBet

Diggs is in a good spot to rack up the receptions as Allen’s top target against a team that can’t stop receivers. We just need Buffalo to contain Tennessee enough to take a halftime lead. If that happens, it can certainly hold on and finish the job.

RELATED: NFL Week 6 Picks And Best Bets For Every Game

Bills vs. Titans Moneyline

The Bills are at -240 on the moneyline, meaning it would take a $240 wager to win $100 in profit. Conversely, the underdog Titans are +195 (a $100 win means $195 in profit). It’s a moneyline spot that sportsbooks are enticing fans of both sides to consider.

The Bills are the NFL’s best team right now, and we’re not going against them. Tennessee’s results are a little more concerning. They were blown out by arguably the other “best team” in the NFL, 38-13 at home by the Cardinals. They lost to the Jets. Tennessee’s inability to protect Ryan Tannehill makes it less likely the Titans can rally. Buffalo to win is the play. You can get the Bills (-255) at DraftKings.

Bet $5, Get $200 in Bonus Bets + No Sweat SGP

Tap for Promo Activated! Visit site

Used 10 Times Today

Bills vs. Titans Point Spread

The Bills are at -5.5 on the point spread, moving from the original line of -3.5 as the market immediately pounced. Jumping on Buffalo early was the wise move. The team leads the NFL in offense and defense, and the Titans have looked susceptible the last couple weeks, including a straight-up loss to the Jets. Is the spread too big to back Buffalo on a Week 6 NFL betting Monday night ticket?

If you’re picking a side, the Bills are the one to go with. Not only do they have a ridiculous 21.6 point differential average so far, that number expands to 26.5 for road games. Tennessee’s offense has actually been worse at home too. Buffalo -5.5 is the best bet if adding MNF to your NFL picks lineup. You can get the Bills -5 (-110) at BetMGM.

Bet $10, Get $200 in Bonus Bets Instantly

Tap for Promo Activated! Visit site

Used 21 Times Today

Bills vs. Titans Totals

The Over/Under for Monday Night Football sits at 54. That is the second-highest total for all of NFL Week 6, with only the 55.5 for Kansas City-Washington topping it. It makes sense, as these teams average over 60 points per game (compared to 44 ppg allowed).

The Over is trending for both teams. It’s on a 5-2 run on Bills games on the road, and any games on Monday night. It’s also 7-1 in Titans games when they’re an underdog and in four of the last five on Mondays. Tennessee can score and can’t stop anyone from doing the same. Signs suggest another shootout here, but the total is so high it offers pause.

Bet $5, Get $200 in Bonus Bets

Tap for Promo Activated! Visit site

Used 34 Times Today