Buffalo Bills NFL Draft Odds: 10 Picks, Not 10 Rookies

The Buffalo Bills enter the 2025 NFL Draft with 10 picks in hand—but there’s little chance all 10 rookies will make the final roster. This is a team trying, once again, to break through the AFC logjam—specifically, to finally get past Patrick Mahomes and the Kansas City Chiefs.

Buffalo’s 32-29 loss in the AFC Championship Game was another gut-punch. The Bills led in the fourth quarter but couldn’t close the door. With some help from Park Avenue, the Chiefs escaped and advanced to Super Bowl 59.

As always, the question lingers: Can Josh Allen ever get past Mahomes in the playoffs?

Armed with ample draft capital, Buffalo is well-positioned to package picks and trade up for blue-chip talent. Rather than add volume, they could target a high-impact rookie to complement an already veteran-laden roster.

The offense remains mostly intact after free agency. Allen continues to prove he can carry the scoring load. The glaring holes lie on defense—expect Buffalo to focus heavily on that side of the ball in Round 1.

With the 30th overall pick, here are the top projected targets for the Bills, according to NFL odds  from Adam Thompson of Bookies.com:

This hypothetical NFL betting market is for entertainment purposes only and does not reflect any market that may be available on betting sites and betting apps.

Buffalo Bills – First Round Draft Player Analysis 

Nick Emmanwori, S, South Carolina (+400)

A fast-rising first-rounder, Nick Emmanwori tested among the best at his position at the combine. He boasts elite physical tools but scouts have questioned his urgency and consistency. The Bills may prioritize upside and athleticism over polish.

Derrick Harmon, EDGE, Oregon (+450)

Derrick Harmon brings versatility and dependable interior pressure to the defensive front. While not flashy, he could help shore up depth and durability issues across the D-line—a smart value pick at No. 30.

Derrick Grant, DL, Michigan (+475)

A 6’4”, 331-pound force in the middle, Derrick Grant was a key cog in Michigan’s 2023 national title run. With rare size and agility, he can stuff the run and collapse the pocket. If available, he’s a high-floor, high-ceiling addition for Buffalo’s trenches.

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Matthew Golden, WR, Texas (+650)

Matthew Golden offers inside-outside flexibility and explosive playmaking. Despite a smaller frame (5’11”, 191 lbs), he led Texas in receiving yards (987) and touchdowns (9) in 2024. NFL Next Gen Stats ranked him fifth among WRs at the combine.

Walter Nolen, DL, Ole Miss (+700)

A Texas A&M transfer, Walter Nolen flashed game-changing traits at Ole Miss—power, quickness, and leverage. At 6’4”, he fits the mold of a classic SEC interior lineman. Next Gen Stats grades him as a potential “Year 1 Starter,” and he could immediately anchor Buffalo’s run defense.

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Maxwell Hairston, CB, Kentucky (+900)

Undersized but scrappy, Maxwell Hairston (5’11”, 183 lbs) has long arms and a nose for the football. A ball hawk in the SEC, he has the versatility to thrive in both zone and man coverage schemes.