Few teams were as impressive in Week 1 as the Buffalo Bills. The opposite could be said of the Tennessee Titans. The teams face off on Monday Night Football in Week 2 NFL betting action. 

Josh Allen and the Bills spoiled the Rams’ championship kickoff celebration by rolling to a 31-10 win in L.A. The Titans, meanwhile, got shocked 21-20 at home by the underdog Giants despite a 266-yard passing performance from Ryan Tannehill. 

Buffalo is favored by 10 points in the latest Titans vs. Bills odds, with an Over/Under of 48 points on betting apps. 

Bookies.com NFL handicapper Adam Thompson – who has hit on a whopping 62-64% of his 
NFL picks three years running – reveals his best bets for the Titans vs. Bills showdown in upstate New York. 

Tennessee Titans vs. Buffalo Bills Point Spread

These teams don’t play each other every year, but the underdog has covered the spread in 10 of the last 11 meetings. Tennessee also has the respect factor going. A team with Derrick Henry, considered a division title contender, as a double-digit underdog coming off a shocking home loss: Those are some good motivations to bounce back. 

Buffalo looked unstoppable in Week 1, but give coaches a week to gameplan against what they’ve seen. We’re not saying Tennessee wins here, but it could take the air out of the ball and try to hang until the end. Tannehill has the arm to lead a backdoor cover, too. Take the Titans and all those points for your Titans vs. Bills picks. 

Tennessee Titans vs. Buffalo Bills Over/Under

The Over has hit in six of the last seven Titans games on Monday. As prolific as the offenses can be, the defenses are just as stout and perhaps more consistent. Buffalo held the Rams to just 243 total yards, the second-lowest total in Week 1. The Titans got gashed by Saquon Barkley but their pass D ranked fourth. 

Each side is suited to limit, to some extent, the other’s strength. Each team played in games that totaled 41 points in Week 1. This total seems a little high, leaning us toward the Under in Buffalo for our Titans vs. Bills best bets. With legal wagering now permitted on New York betting apps, this is one of our favorite plays for Bills fans on this matchup.

$1,000 First Bet on Caesars Promo Code: BOOKIES1000

Tap for Promo Activated! Visit site

Used 6 Times Today

Must be 21+ to participate. T&Cs apply.

Tennessee Titans vs. Buffalo Bills Moneyline

Tennessee is going to feed Henry. A lot. If it works, the Titans stay in this game. If it doesn’t, things could get ugly. 

Either way, the Bills, at home, is a tough get for a Tennessee team that failed to play a full four quarters against Daniel Jones and the Giants. When looking at the NFL odds, the -450 price for Buffalo is big, but if you’re playing a moneyline side, Buffalo is it.

Bet $5, Get $150 Instantly

Tap for Promo Activated! Visit site

Used 6 Times Today

21+ and present in most states. (18+ DC/KY/NH/WY). Void in IA/KS/KY/LA/MD/MI/NJ/NY/TN/VA/VT/ONT. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). 1 per new customer. Min. $5 deposit. Min. $5 bet. Max. $150 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: dkng.co/bball. Ends 1/5/25 at 11:59 PM ET. Sponsored by DraftKings. GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD).

Best Titans vs. Bills Player Props

Derrick Henry, Over 21.5 Rushing Attempts

Odds: +110 at DraftKings

The more the Titans feed their RB1, the higher probability for team success. Only once in eight games did Henry rush for under 20 yards, and that was in Week 1 in a 25-point blowout loss. They were 6-1 in the games he got 20-plus carries. In 2020, the Titans were 0-1 when he got 21-plus carries, 1-4 when he didn’t. 

Henry rushed 21 times for 82 yards in last week’s surprising home loss to the Giants. Buffalo allowed only 52 rush yards in Week 1, but the Rams don’t have anyone resembling Derrick Henry. The key for Tennessee is keeping the ball for as long as possible and keeping Josh Allen off the field. Henry should get the rock 25-plus times. Get these plus odds at DraftKings. 

Devin Singletary, Over 44.5 Rushing Yards

Odds: -115 at BetMGM

Singletary gained 48 yards against the stout Rams run defense – on only eight carries. No team, meanwhile, allowed more than the 238 rushing yards the Titans gave up to the Giants. 

Simply, Buffalo is a better team when Singletary is involved more. They were 7-0 last season when he received 12-plus carries, and 4-6 when he didn’t. All seven of those wins were by double figures, six by at least two TDs. If Allen is on, the lanes open for Singletary. Get these odds at BetMGM.

Up to $1,500 in Bonus Bets if Your First Bet Loses Promo Code: BOOKIES

Tap for Promo Activated! Visit site

Used 9 Times Today

Bonus Bets Expire in 7 Days. One New Customer Offer Only. Must be 21+ to participate & present in OH. In partnership with MGM Northfield Park. Gambling problem? Call 1-800-GAMBLER. Visit BetMGM.com for T&Cs. US promotional offers not available in NY, NV, or Puerto Rico.