Two of the AFC’s leading Super Bowl contenders face off in a Monday Night Football afternoon showdown, as Josh Allen and the Buffalo Bills host Patrick Mahomes and the Kansas City Chiefs.

Each team is coming off a surprising first defeat. The Bills (4-1) were embarrassed 42-16 at Tennessee and the Chiefs (4-1) lost 40-32 at home to the Raiders.

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The Bills have covered the spread in seven of the past 10 meetings between these teams, but the Chiefs have covered in eight of nine vs. teams with above-.500 records. Let’s take a look at some of the best NFL betting wagers that fans should consider:

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Best Bills-Chiefs Odds & Props To Back

NFL odds listed are current as of publication and subject to change.

Bills +4.5

The Bills didn’t look ready to play in a Tuesday night game filled with bizarre mental errors. Allen didn’t play well and Devin Singletary was a non-factor. But Allen was crazy consistent in his previous games. Singletary should find lanes against KC’s 28th-ranked run defense. Together, they can keep up against Mahomes. Find the best odds for the spread at FOX Bet.

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Chiefs-Bills Over 57.5

The Bills had scored between 27 and 35 points in their first four games before the 16-point dud on Tuesday. We know what the Chiefs offense is capable of. Each team’s offensive strength matches up well with the opposing defense weaknesses. Expect points scored early and often. Locate the best odds for the total at Unibet.

First Half – Over 27.5 Points

Every Bills game has hit at least 24 points in the first half, with the two games under 28 due to a three-point effort by the opponent. That’s not happening here. Two of KC’s last three games had at least 37 points at the break. With offense the theme of this one, look for both teams to come out firing – and scoring. Find the best first-half total odds at BetMGM.

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Team To Throw 1st INT – Neither

Allen has thrown just three INTs on the season and only one was his fault. Mahomes has just one pick. Combined, the defenses combine to average less than one pick per game. Play the trends at plus odds. Lock in the best INT number at PointsBet.

Josh Allen – Over 250 Yards

Allen’s lowest output this season is 263 yards. His second-lowest was 283. The Chiefs have allowed at least 250 yards three of five games, and all against QBs of similar attempt numbers Allen is likely to have. Get the highest odds for the Allen yards prop at PointsBet.