The hot streak of the Indianapolis Colts came to a stunning halt last Sunday. Facing the reigning Super Bowl champion Tampa Bay Buccaneers, Tom Brady showed he still knows how to haunt the Colts’ dreams, rallying the Bucs from a 24-14 deficit for a 38-31 victory.

At sportsbooks the belief is that the Colts get the perfect remedy for such heartbreak this week in the 2-9 Houston Texans. It’s NFL rushing leader Jonathan Taylor (1,205 yards) facing the NFL’s second-worst run defense. In NFL picks, Indianapolis is a solid 8.5-point road favorite.

Take a look at Colts vs. Texans odds, injury report, betting lines and more.

Colts vs Texans Key Matchups

Jonathan Taylor vs Houston Defense: Colts RB Jonathan Taylor has 1+ rush TDs in nine straight games. Only Lenny Moore (11 straight from 1963-64) has a longer streak in Colts history. The Texans are 31st in the NFL at stopping the run (135.63 yards per game allowed).

Carson Wentz vs Opportunistic Texans: The Achilles heel of Colts QB Wentz has always been turnovers. His three interceptions helped pave Tampa Bay’s path back to victory last week. Houston’s defense has snatched 11 takeaways through their past three games.

Is It COVID?: The Texans shut their entire facility down Wednesday after a number of players came down with a mysterious illness. Thus far, the team hasn’t reported any positive COVID-19 tests but with so many players across the league falling victim to the virus this week, this news has to be disconcerting.

RELATED: NFL Week 13 Odds & Betting Lines For All Games

5 Key Colts vs Texans Stats

11: Takeaways by the Texans over their last three games. They had a franchise-low nine takeaways in 2020.

23: Number of 10+ tackle games for Colts LB Darius Leonard. That’s the most by any Indy player since 2000.

17: Rushing TDs allowed by the Texans, second-most in the NFL.

17: Rushing TDs scored by the Colts, second-most in the NFL.

14.9: Points per game scored by the Texans. That’s the worst scoring offense in the NFL.

RELATED: NFL Week 13 Picks & Best Bets For Every Game

Colts vs Texans Player Props

Colts RB Jonathan Taylor over 105.5 rushing yards

Odds: -115 at Caesars Sportsbook

Taylor figures to bounce back strongly against Houston’s dreadful run defense.

$1,000 First Bet on Caesars

Tap for Promo Activated! Visit site

Used 70 Times Today

OH only. 21+. New users and first wager only. Must register with eligible promo code. Bet amount of qualifying wager returned only if wager is settled as a loss. Maximum bet credit $1,000; must be used within 14 days of receipt. See Caesars.com/promos for full terms. Void where prohibited. Know When To Stop Before You Start.® Gambling problem? Call 1-800-GAMBLER

Colts QB Carson Wentz under 249.5 passing yards

Odds: -115 at Caesars Sportsbook

Wentz won’t need to air out the ball against the Texans because Indy figures to be leading comfortably.

Colts RB Jonathan Taylor 2+ TDs

Odds: +185 at FanDuel Sportsbook

He’s scored nine games in a row. Keep riding this horse until he doesn’t get to the end zone.

Bet $5, Get $150 in Bonus Bets

Tap for Promo Activated! Visit site

Used 15 Times Today

Must be 21+ and present in OH. Gambling Problem? Call 1-800-GAMBLER.

Colts vs Texans Moneyline

Overall, the Colts have won three in a row straight up from the Texans. At Houston’s NRG Stadium, Indy is 4-1 SU in the last five games played there between the two teams. The Colts beat the Texans 31-3 earlier this season at Indy on Oct. 17.

Indianapolis is 3-2 SU on the road this season. Houston is 1-4 SU at home during the 2021 campaign. Both FiveThirtyEight (Indy 77 percent) and the ESPN Football Power Index (Indy 75.7 percent) are heavy backers of the Colts in the analytics. But at odds of -400 on betting apps, it’s best to just lay off the moneyline play on this game.

$1,000 First Bet on Caesars

Tap for Promo Activated! Visit site

Used 63 Times Today

OH only. 21+. New users and first wager only. Must register with eligible promo code. Bet amount of qualifying wager returned only if wager is settled as a loss. Maximum bet credit $1,000; must be used within 14 days of receipt. See Caesars.com/promos for full terms. Void where prohibited. Know When To Stop Before You Start.® Gambling problem? Call 1-800-GAMBLER

Colts vs Texans Point Spread

When it comes to NFL betting, the Colts are point spread road warriors. Indy is 4-0 against the spread in the club’s last five road games. The Colts are also 5-0 ATS in their last five games following a game in which they failed to cover, as happened last week against the Buccaneers.

Indianapolis is 6-1 ATS in the last seven games against the Texans and 5-0 ATS in the last five games played at Houston. Overall, the Colts are 6-3 ATS in their last nine games. Normally, 8.5 points is a lot to give a home team in NFL spreads wagering. In this case, the Colts will easily cover. Lay the points. You can get the Colts -9.5 (-115) at DraftKings.

If jumping on the Colts' spread, then don't forget to check out the latest DraftKings promo code first. New sign-ups can bet $1 and get $100 in free bets with their first NFL wager, as long as a single point is scored in the matchup.

Bet $5, Get $200 in Bonus Bets + No Sweat NBA SGP Every Day Of The Playoffs

Tap for Promo Activated! Visit site

Used 74 Times Today

Must be 21+ and present in OH. Gambling Problem? Call 1-800-GAMBLER.

Colts vs Texans Totals

On the surface, at 45 points the total offered at NFL betting sites might seem to be a low one. In point of fact, the total has gone under that number in three of the last four games between the Colts and Texans. The under is 5-1 in Houston’s last six games. The under is also 6-1 in Indy’s last seven AFC South divisional games.

On the other hand, the total has gone over in five of the Colts’ last six games and seven of their past eight road games. Indy will do its part to put up points. Houston won’t. The Texans have been held under 20 points in eight of 11 games. The under is the play. You can get Under 45.5 (-110) at FanDuel.

Bet $5, Get $150 in Bonus Bets

Tap for Promo Activated! Visit site

Used 35 Times Today

Must be 21+ and present in OH. Gambling Problem? Call 1-800-GAMBLER.