• Bookies
  • NFL
  • NFL Picks
  • Indianapolis Colts vs Los Angeles Chargers Odds, MNF Picks & Predictions

Indianapolis Colts vs Los Angeles Chargers Odds, MNF Picks & Predictions

Adam Thompson for Bookies.com

Adam Thompson  | 5 mins

Indianapolis Colts vs Los Angeles Chargers Odds, MNF Picks & Predictions

First Bet Safety Net Up To $1,000

Visit site
Used 29 Times Today
Popular in Ohio
Deposit required. Paid in Bonus Bets. Bets wager excluded from returns. New Customer only. Must be 21+ and present in OH. T&Cs apply. Gambling Problem? Call 1-800-GAMBLER.
Bookies Plus
WHY BOOKIES PLUS?
  • Daily expert picks delivered to your email (Over 60% NFL winning percentage!)
  • Opportunities to compete against pro handicappers + win prizes (Bragging Rights 😁)
  • Follow handicappers who are riding hot 🔥
  • Exclusive betting offers from top sportsbooks
  • It’s FREE and takes 30 seconds to sign up!

Justin Herbert and the Los Angeles Chargers look to keep pace in a tight AFC Playoffs race as they head to Indianapolis to face the Colts in the Week 16 edition of Monday Night Football.

The Chargers (8-6) were in the No. 6 spot in the AFC heading into Week 16, but the No. 7 Dolphins are also at 8-6 with six additional teams at 7-7 or 6-8. The Colts are 4-9-1 and mostly out of the mix following the shocking 36-39 OT loss at Minnesota last week. 

The latest Chargers vs. Colts odds have L.A. favored on NFL betting sites by 4.5 points with an Over/Under of 45 points.

Bookies.com NFL handicapper Adam Thompson – on a 67% run the last month for his NFL picks – locks in his best bets for the Monday night matchup. 

Chargers vs. Colts Point Spread Pick

Content Block With Header And Image - Left

The Colts led the Vikings 33-0 in the second half last week, only to lose in the biggest gag in NFL history. Now Indy soldiers on without top RB Jonathan Taylor (ankle) and QB Matt Ryan (benched) as the team plays out the year. 

Here’s the thing: Nick Foles isn’t terrible, and the defense ranks top 10 vs. the run. Indy is only 2-4 at home but two losses were by a single point, the other two also by a single score. The Chargers’ one-dimensional offense may have issues. We’re not backing the Colts to win, even at home, but don’t expect a blowout. Take Indy +4.5. 

$1,000 First Bet on Caesars

Visit site
Used 71 Times Today
OH only. 21+. New users and first wager only. Must register with eligible promo code. Bet amount of qualifying wager returned only if wager is settled as a loss. Maximum bet credit $1,000; must be used within 14 days of receipt. See Caesars.com/promos for full terms. Void where prohibited. Know When To Stop Before You Start.® Gambling problem? Call 1-800-GAMBLER

Chargers vs. Colts Over/Under Best Bet

Content Block With Header And Image - Left

The Chargers have won three of four and gotten back on track because their defense has played better. With that, the Under has looked better, hitting in three straight L.A. games and four of its last five victories. 

The Over has actually hit in Indy’s last three, bucking a season-long trend of Unders. The Under has been the winner in a majority of Colts home games and Chargers road games, too. The defenses should find an edge on Monday night. Back the Under. 

Bet $5, Get $200 In Bonus Bets Instantly!

Visit site
Used 40 Times Today
Must be 21+ and present in OH. Gambling Problem? Call 1-800-GAMBLER.

Chargers vs. Colts Moneyline Pick

Content Block With Header And Image - Left

The favored Chargers are -215 on the moneyline while the Colts are at +185. We’re going with Indianapolis to cover the 4.5-point spread, but don’t trust them enough to pick a win, especially after last week’s debacle in Minnesota. 

Los Angeles makes sense here, but expect a close game. The Chargers have lost three of their last four on the road, the lone win at brutal Arizona. We strongly prefer L.A. on this night, but that lack of consistency is enough to shy us off the moneyline. The spread is favorable over the ML. 

Best Chargers vs. Colts Player Props

Content Block With Header And Image - Left

Nick Foles, Over 231.5 Pass Yards

Odds: -110 at DraftKings

With no Jonathan Taylor, an energetic, learning coach and likely facing a deficit in the second half, the Colts are going to throw the ball around. Foles got one start last year for the Bears; he threw for 250 yards with a far-worse offense than this one and beat the Seahawks as seven-point underdogs. No Joey Bosa offers a little extra time. 

Cameron Dicker, Over 7.5 Points

Odds: +100 at BetMGM

The Colts rank 31st in red zone TD percentage. Fortunately LA has a kicker that’s missed one field goal all season and zero extra points. Cameron Dicker has scored eight-plus points in six of his eight games.

Up to $1,500 in Bonus Bets if Your First Bet Loses
Promo Code: BOOKIES

Visit site
Used 24 Times Today
Bonus Bets Expire in 7 Days. One New Customer Offer Only. Must be 21+ to participate & present in OH. In partnership with MGM Northfield Park. Gambling problem? Call 1-800-GAMBLER. Visit BetMGM.com for T&Cs. US promotional offers not available in NY, NV, or Puerto Rico.

About the Author

Adam Thompson for Bookies.com
Adam Thompson
Long established as one of the nation's premier handicappers, Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine & CBSSports.com. He specializes in the NFL and MLB, where he's hit on well over 60% of his picks the past five years. Adam's NBA and horse racing picks have also produced consistent, major winners over the years.