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LA Rams vs San Francisco 49ers Best Bets, Odds & Picks

Adam Thompson for Bookies.com

Adam Thompson  | 6 mins

LA Rams vs San Francisco 49ers Best Bets, Odds & Picks

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Jimmy Garoppolo and the San Francisco 49ers look to rebound from a primetime loss at Denver with another matchup under the lights, this one at home against Matthew Stafford and the Los Angeles Rams on the Week 4 edition of Monday Night Football. 

Garoppolo has never lost to the Rams in the regular season, a perfect 6-0, though the last matchup, in the 2022 NFL Playoffs, went to L.A., a 20-17 decision that put the Rams in the Super Bowl. The Rams are 2-1 but it hasn’t come easy. After getting blown out by the Bills to open the season, L.A. beat Atlanta and Arizona, but had to stave off late rallies. 

The host 49ers opened as two-point favorites with an Over/Under set at 42 points on NFL betting sites. The latest Rams vs. 49ers odds have shifted to -1.5 for San Fran. 

Bookies.com NFL handicapper Adam Thompson – who hit on 80% of his NFL picks in Week 3 – reveals his plays for the NFC West showdown. 

Rams vs. 49ers Point Spread Pick

The Niners have won five straight vs. the Rams (in the regular season) and six straight with Jimmy G, and all of those games when they were the underdog. Now L.A. is the underdog, and on the road. 

Still, there isn’t a no-brainer side to choose on betting apps for Monday Night Football. Garoppolo looked borderline lost at times under center vs. the Broncos in Week 2. The run game ranks sixth right now but the horses aren’t there to keep it going and L.A. is brutally tough vs. ground attacks. That means the Niners need Garoppolo to lead the way. 

The Rams have looked great early on to build leads, then allowed teams back into it. Still, both recent games were wins. They’ve learned a lot since their Week 1 beatdown by Buffalo. We expect them to keep it going here. Take the points with the road dog Rams on betting sites for your Rams vs. 49ers picks. 

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Rams vs. 49ers Over/Under Best Bet

Star left tackle Trent Williams injured his ankle last week vs. the Broncos. The very next play, Garoppolo was sacked. Jimmy G might be seeing ghosts early and often in the pocket for the Niners. There is no great matchup here for an offense that’s scored 10 points in two of three games.

The Rams managed only 20 in a win vs. the defense-challenged Cardinals, so offense has come and gone for them as well. The Under has hit in four of the last five meetings and is on a 10-1 run in all 49ers games. We expect that trend to continue. The Under is our favorite Rams vs. 49ers pick for Monday Night Football. 

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Rams vs. 49ers Moneyline Pick

We’re picking the underdog to win, and so we’re taking them on the moneyline as well. But only a small amount. This is a field-goal-to-win-it NFL season so far. And even 1.5 points, or +2 if you can find it, might be well worth it when the clock strikes 00:00. 

This is a rivalry game and one in which the 49ers have owned of late. The matchups favor the Rams, especially for their defense. We’ll take the points over the moneyline, but either way it’s Rams to win. 

Best Rams vs. 49ers Player Props

Jimmy Garoppolo, Over 223.5 Passing Yards

Odds: +100 at BetMGM

Garoppolo threw for 211 yards in a dud of a first start against the Broncos in Week 3. His confidence shouldn’t be too shaken with a matchup against the Rams looming. In six career regular-season starts, Garoppolo has not only won them all but he’s also averaged 258 yards and 1.5 TDs in them. Only once was he held to under 243. The Rams allow 269 pass yards per game. Back Jimmy G and the Over. 

Jeff Wilson, Over 69.9 Total Yards 

Odds: -115 at DraftKings

In two starts for Wilson, the 49ers running back has totaled 103 and 106 yards, highly consistent and also way above this posted total. Deebo Samuel’s rush totals have gone down with Garoppolo back under center because the QB can get the ball to the WR downfield. Wilson is the guy in the backfield now. The Rams’ front 7 can be tough on RBs, but this total seems too low. 

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About the Author

Adam Thompson for Bookies.com
Adam Thompson
NFL writer and expert Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine and CBSSports.com. He's long been established as one of the nation's premier handicappers, specializing in the NFL where he's hit on more than 60% over the past three years. Adam's NBA, PGA and horse racing picks have also produced major winners over the last 12 months. His customized NFL and NBA odds for players and teams have been picked up by hundreds of websites over the past year.