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NFL Week 5 Picks, Betting Predictions & Best Bets To Back

Bill Speros for Bookies.com

Bill Speros  | 37 mins

NFL Week 5 Picks, Betting Predictions & Best Bets To Back

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A run of big-name matchups and Mega QB showdowns gives way to the mundane in Week 5 of the NFL betting season. This offers the last full schedule of games until Week 13. But while there are no Brady-Mahomes matchups to consider, there’s always opportunities for bettors to find green among the pale pastels stuffed into this week’s schedule.  

And you can still catch the Joe Burrow-Lamar Jackson rivalry in its early stages. The Bengals and Ravens meet on Sunday night in Baltimore. Burrow has taken two of the first three meetings between the top-tier QBs. 

The NFL’s overseas games continue with the New York Giants serving as “host” to the Green Bay Packers in London. King Charles III and Queen Consort Camilla are not expected to attend.

The Kansas City Chiefs play host to AFC West rival Las Vegas Raiders on Monday night. Kansas sports betting went live on Sept. 1. 

Other intra-divisional matchups on the schedule include: The Dolphins at Jets; Falcons at Buccaneers, and the above-mentioned Bengals at Ravens on Sunday night. 

The NFL Red Zone is going to have to unveil the Ennea-Box starting at 1 p.m., as there are nine games being played in the early Sunday afternoon time slot. The national game is at 4:25 p.m. ET on FOX and will likely be the Cowboys at Rams, with the Eagles and Cardinals as the second choice. 

RELATED: All NFL Head Coaches Ranked Against the Spread

Now it’s on to our Week 5 NFL picks to back on your sports betting app: 

NFL 2022 Season Week 5 Picks

Oddsmakers on betting apps have set betting lines on these games. Let's take a look at the schedule for our NFL Week 5 picks and best bets: 

DateMatchupWeek 5 Picks
Thursday, Oct. 6Colts @ Broncos Over 42.5 Points ➜
Sunday, Oct. 9Giants @ Packers (London) Giants ATS ➜
Sunday, Oct. 9Steelers @ Bills Bills ATS ➜
Sunday, Oct. 9Chargers @ Browns Under 48 Points ➜
Sunday, Oct. 9Texans @ Jaguars Jaguars ATS ➜
Sunday, Oct. 9Bears @ Vikings Bears ATS ➜
Sunday Oct. 9Lions @ Patriots Patriots Moneyline ➜
Sunday, Oct 9Seahawks @ Saints Under 43.5 Points ➜
Sunday, Oct. 9Dolphins @ Jets Dolphins ATS ➜
Sunday, Oct. 9Falcons @ Buccaneers Buccaneers ATS ➜
Sunday, Oct. 9Titans @ Commanders Titans Moneyline ➜
Sunday, Oct. 949ers @ Panthers 49ers ATS ➜
Sunday, Oct. 9Eagles @ Cardinals Over 49.5 Points ➜
Sunday, Oct. 9Cowboys @ Rams Under 45.5 Points ➜
Sunday, Oct. 9Bengals @ Ravens Bengals ATS ➜
Monday, Oct. 10Raiders @ Chiefs Chiefs ATS ➜

All NFL Week 5 best bets are accurate as of publication (Oct. 4). NFL Week 5 picks are subject to change. Use the BetMGM promo code BOOKIESPICKS to get a $1,000 risk-free bet for your NFL Week 5 picks.


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2022 NFL Week 5 Best Bets To Back Today

Indianapolis Colts at Denver Broncos, Thursday, 8:15 p.m. (Amazon Prime)

The two senior QBs who switched teams this offseason face off in the altitude of Denver. Matt Ryan came to the Colts after 14 seasons in Atlanta. Russell Wilson landed in Colorado after 13 years with Seattle. Expect plenty of yards through the thin air of Empower Field at Mile High – as long as Nathaniel Hackett lets Russ do more than cook in the microwave.

Best Bet: Over 42.5 Points (-110) with Caesars Sportsbook ➜

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NY Giants vs. Green Bay Packers (London), Sunday, 9:30 a.m. (FOX)

The second of four international games this season sees the Giants and Packers playing at Tottenham Hotspur Stadium in London. This is the third game in the United Kingdom for the Giants, while the Packers are playing their first regular-season game outside the United States. The Giants and rookie coach Brian Daboll will try to keep the ball on the ground and out of Aaron Rodgers’ hands. Saquon Barkley will be the key. He's looked like superstar Saquon again so far. The Packers were pushed to overtime by Bailey Zappe and the Patriots at Lambeau in Week 4. Both the Packers and Giants are 3-1 and are closer than this line indicates. Or as they appear in your rear-view mirror. Take the Giants for your NFL Week 5 best bets.

Best Bet: Giants +7.5 Points (-110) with Caesars Sportsbook ➜


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Pittsburgh Steelers at Buffalo Bills, Sunday, 1 p.m. (CBS) 

This is the largest single-game line of the young season. The Bills remain among the favorites to - finally - win a Super Bowl. After that thrilling comeback in Baltimore, the Super Bowl hype is as real as it's been since Scott Norwood lined up the potential game-winner against the Giants in Super Bowl 25. There are no odds available on the number of tablets Ken Dorsey will destroy during this game. But we'd go with the under if there was one because the Bills offense should be back to its early-season form here. Hence the monstrous line. 

The Steelers are adjusting to life after Big Ben. It's not going well. They lost at home to the Jets. Normally, we'd take the points on a line like this, but the Bills are playing for keeps this year and championship teams usually win games like this going away. Take the Bills for your NFL Week 5 picks.

Best Bet: Bills -13 (-110) with DraftKings Sportsbook ➜


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L.A. Chargers at Cleveland Browns, Sunday, 1 p.m. (CBS)

Two perpetual underachieving teams collide in what has all the ingredients of a 10-10 tie. The Chargers remain frozen in mediocrity while the Browns are merely trying to remain viable and above water during the Deshaun Watson suspension. Grab the under for your NFL Week 5 best bets.

Best Bet: Under 48 Points (-110) with DraftKings Sportsbook ➜

RELATED: NFL Week 6 Best Bets, Predictions and Picks

Houston Texans at Jacksonville Jaguars, Sunday, 1 p.m.  (CBS)

The Jags were the first AFC South team to win two games and still a share of first place. Doug Pederson and Trevor Lawrence will continue to make strides each week. Jacksonville's defense smothered the Chargers in Week 3. But we'll need to see more of that to be convinced it is legit. The Jags need to stack wins against teams like the Texans if they want to convince themselves and the rest of the NFL that they are something more than a perennial contender for No. 1 overall draft pick. The Texans, meanwhile, are playing like the favorite for the No. 1 overall draft pick. We grabbed this one at -6.5. Beware the hook on 7 points for your NFL Week 5 best bets. 

Best Bet: Jaguars -6.5 (-110) with FanDuel Sportsbook ➜

Chicago Bears at Minnesota Vikings, Sunday, 1 p.m. (FOX)

It will be loud inside US Bank Stadium, unless the Bears win. And since betting is still illegal in Minnesota, it will stay loud if the Vikings win but don't cover. We like the Bears against the spread.

Best Bet: Bears +6.5 (-110) with DraftKings Sportsbook ➜


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Detroit Lions at New England Patriots, Sunday, 1 p.m.  (FOX)

The Lions won hearts and minds last season by going 11-6 ATS despite a 3-13 record straight up. Their brand grew even larger thanks to the dynamism of coach Dan Campbell on "Hard Knocks" this past summer. Now, just imagine the Patriots and Bill Belichick on “Hard Knocks.” Each episode would run about 48 seconds. This game remains a pick 'em depending on where you shop. The Patriots are back to their pre-Brady form and celebrating "Moral Victories" - such as taking the Packers to overtime behind rookie QB Bailey Zappe before losing 27-24. Look for the Patriots to get an old-fashioned victory on the scoreboard. 

Best Bet: Patriots Pick (-110)   with DraftKings Sportsbook ➜

Seattle Seahawks at New Orleans Saints, Sunday, 1 p.m. (FOX)

The Seahawks offense was money in Week 4.  Rashaad Penny ran for 151 yards and scored a pair of touchdowns as Seattle scored 48 points against Detroit. Geno Smith added 320 yards through the air and a pair of TD tosses. The Saints return from a tough loss in London. The total on this game soared from 41 points to 47.5 points after Sunday's results. This has the potential to be a low-scoring, ugly slog. Take the under for your NFL Week 5 best bets.

Best Bet: Under 43.5 Points (-110) with DraftKings Sportsbook ➜

Miami Dolphins at New York Jets, Sunday, 1 p.m. (FOX)

The Dolphins are a solid team with serious expectations to reach the playoffs. But they now have a question mark at QB. The status of Tua Tagovailoa is as uncertain as the track of the next hurricane to hit Florida. Teddy Bridgewater is Miami's starting QB for now. He has the best winning percentage ATS of any current NFL quarterback with more than 10 starts. The Jets last won a Super Bowl before man walked on the moon. But they did win at Pittsburgh Sunday.

Best Bet: Dolphins -3 (-118) with FanDuel Sportsbook ➜


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Atlanta Falcons at Tampa Bay Buccaneers, Sunday, 1 p.m.  (CBS)

After back-to-back losses to Aaron Rodgers and Patrick Mahomes II, the Buccaneers get a breather of sorts as Marcus Mariota and the Falcons visit Raymond James Stadium. Brady once beat the Falcons in a Super Bowl after trailing 28-3. Since joining the Bucs in 2020, Brady has averaged 358.2 yards passing against Atlanta and thrown 15 TD passes in just four games. Last season, Tampa Bay covered both double-digit spreads against Atlanta. Brady has not lost three games in a row since the Truman Administration. Or so it seems. In reality, it's been almost 20 years. On October 27, 2002, he and the Patriots dropped their fourth straight decision. Brady and Mike Evans got their groove back in a 41-31 loss on Sunday night. The Buccaneers defense was surprisingly horrid against Mahomes and the Chiefs. Tampa Bay should right the ship this week. Grab them quick for your NFL Week 5 best bets before the line balloons.

Best Bet: Buccaneers -8 (-110)   with FanDuel Sportsbook ➜

Tennessee Titans at Washington Commanders, Sunday, 1 p.m. (CBS)

Both coaches (Mike Vrabel of the Titans and Washington’s Ron Rivera) are former NFL defensive stars who continue to flirt with the proverbial hot seat, mostly due to the lack offensive production. Such irony. There's no such thing as a home-field advantage at FedEx Field. The Titans have won two straight and scored a critical AFC South win at Indianapolis. The Commanders are the lone drag in the NFC East, which has 11 wins, the most of any division in the NFL. We grabbed Tennessee as a pick 'em when this line was initially set for our NFL Week 5 picks. The line has since moved to Tennessee -2.5.  

Best Bet: Titans Moneyline (-140) with Caesars Sportsbook ➜

San Francisco 49ers at Carolina Panthers, Sunday, 4:05 p.m. (CBS)

Jimmy Garoppolo vs. Baker Mayfield. Two of the top "Almost-Elite" QBs of the 21st century meet in Charlotte. Neither expected to be with their respective teams at the end of last season. And Mayfield, for one, doesn't seem very happy in the Queen City these days. After a three-turnover performance in Week 4, he and the hometown Cats were booed lustily when Mayfield ended their chances after his fourth deflected pass of the game. 

“I don’t care about the fact that our fans are booing, or what’s going on,” Mayfield said. “When we figure it out and we win, it’s still going to be just us in the locker room — and that’s all we care about.” That's never good. Garoppolo, meanwhile, is money until he gets a 10-point lead in the NFC championship game or Super Bowl. 

Best Bet: 49ers -4 (-110) with DraftKings ➜


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Dallas Cowboys at LA Rams, Sunday, 4:25 p.m. (FOX)

This is likely the earliest Dak Prescott could return from his thumb injury. But Cooper Rush is 4-0 as a starter both against the line and straight up. Jerry Jones will no doubt advise Mike McCarthy to make whatever the wrong decision is if Prescott is fully healthy. The Rams are looking ominous again after their humbling to the Bills in Week 1. LA will be coming off a Monday night affair against division-rival San Francisco. 

Best Bet: Under 45.5 Points (-110)   with DraftKings ➜

Philadelphia Eagles at Arizona Cardinals, Sunday, 4:25 p.m.  (FOX)

Two offenses that could be moving toward opposite destinations. The Eagles have all the buzz while the Cardinals may have already peaked in this iteration. The 4-0 Eagles are the lone unbeaten team in the NFL heading into this Week 5 matchup. The remaining members of the 1972 Dolphins will have the champagne on ice. But there will be no cork popping on this Sunday. Given the size of this line, we're focused on the total. Philly has scored 24 or more points each week this season and is averaging 27.8 points per game. The Cardinals can be productive, too. We like the Over for our NFL Week 5 best bets.

Best Bet: Over 49.5 Points with BetMGM Sportsbook ➜

Cincinnati Bengals at Baltimore Ravens, Sunday, 8:20 p.m. (NBC)

Burrow and Jackson represent two different versions of the quarterback of the future – or present. Burrow drops back and slings it. Jackson is all over the field and slings it – if he’s not headed downfield first. There will be an ample amount of hype generated before this game. The defenses will determine whether or not it meets early billing. The Ravens have been treating big leads like a Jenga Tower. This one should be close throughout.

Best Bet: Bengals +3 (+102) with FanDuel Sportsbook ➜


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Las Vegas Raiders at Kansas City Chiefs, Monday, 8:15 p.m. (ESPN)

Patrick Mahomes was in full Slytherin form against the Buccaneers Sunday night. If he uses half the wizardry in Kansas City against the no-one-can-believe-they-actually-won-a-game Raiders, the Chiefs could put this one away early. The Chiefs at -6.5 looks good for our NFL Week 5 best bets.

Best Bet: Chiefs -6.5 (-110) with DraftKings ➜

About the Author

Bill Speros for Bookies.com
Bill Speros
Bill Speros is an award-winning journalist and editor whose career includes stops at USA Today Sports Network / Golfweek, Cox Media, ESPN, Orlando Sentinel and Denver Post.
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