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NFL Thanksgiving Day Picks, Odds & Best Bets To Back For Week 12: Let's Talk Turkey

Bill Speros for Bookies.com

Bill Speros  | 12 mins

NFL Thanksgiving Day Picks, Odds & Best Bets To Back For Week 12: Let's Talk Turkey

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The NFL celebrates Thanksgiving with three games that can be profitable for bettors, but only if you stick with what’s on our menu. 

Thanksgiving Day means family, food, backyard football, your crazy Uncle Jimmy, and a solid menu of NFL betting opportunities. 

Let's gobble up some winners.

The Detroit Lions and Dallas Cowboys enjoy their traditional spots on the NFL Thanksgiving Day schedule. But this year, even that piece of history comes with a twist. The Buffalo Bills had their “home” game relocated from Western New York to Detroit on Sunday against the Browns thanks to about 500 feet of snow (or 80 inches) that buried Orchard Park and vicinity. 

RELATED: All NFL Head Coaches Ranked Against the Spread

Just four days later, the Bills will be playing the Lions at Ford Field as the holiday visitor. The Lions have won three straight - including a rout of the Giants Sunday - to keep Dan Campbell employed. The Bills need each win they can get in Detroit just to keep pace in the surprisingly competitive AFC East.

In the late afternoon game on FOX, the Dallas Cowboys and New York Giants meet at Jerry World in a game that could have playoff ramifications. 

But don’t fill up in the afternoon. Same some room for dessert Thursday night. The New England Patriots visit Minnesota in the Thanksgiving Day nightcap. These two teams combined to score 6 points on offense Sunday - but the Patriots still managed to beat the Jets. 

Now it’s on to our Thanksgiving Day 2022 NFL picks to back on your sports betting app: 

NFL 2022 Thanksgiving Day Picks

Oddsmakers on betting apps set betting lines on the three Thanksgiving Day games months ago. Here are our picks and best bets on the latest numbers:

DateMatchupThanksgiving Day Picks
Thursday, Nov. 24Bills @ Lions Lions ATS ➜
Thursday, Nov. 24Giants @ Cowboys Giants ATS ➜
Thursday, Nov. 24Patriots @ Vikings Over Points Total ➜

All NFL Thanksgiving Day best bets are accurate as of publication. Our picks are subject to change. Use the BetMGM promo code BOOKIESPICKS to get a $1,000 risk-free bet for your NFL picks.

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2022 NFL Thanksgiving Day Best Bets To Back Today

Buffalo Bills at Detroit Lions, 12:30 p.m. (CBS)

What’s worse than having to play one game in Detroit in a week? How about two? The Bills had their Sunday “home” game against the Cleveland Browns shifted to Ford Field because of an Old Testament blizzard that smothered the south shore of Lake Ontario. While they may be omnipotent, there’s no way the NFL schedule-makers could have known the Bills' Week 11 home game would be moved to Detroit four days before this “road” game. 

The Bills went back to Buffalo Sunday and will return to Detroit later this week. The Bills need every win they can get – in Detroit or elsewhere – to hold their spot in the AFC East. The Lions wrecked the Giants at MetLife Stadium on Sunday. They are 6-4 ATS despite their 4-6 overall record and can be sneaky good against the line. This number might be just enough for them to grab a home cover before some home cooking. This line ebbed a half-point after Sunday's results. 

Best Bet: Lions +9.5 (-110) with Caesars Sportsbook ➜

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New York Giants at Dallas Cowboys, 4 p.m. (FOX)

The Giants were mauled 31-18 at home by the Lions Sunday. The Cowboys demolished the Vikings 40-3 in Minnesota. Given the multiple personalities displayed by the NFL this season, we can expect the Giants to rediscover their offense and the Cowboys to sputter on offense. The Giants are 7-3 outright and ATS. But the 8-2 Vikings have whiffed against the line, going just 4-5-1. This line moved 1.5 points Sunday night, which works perfectly with the NFL's schizophrenic narrative. 

Not only is this game for playoff position and NFC East bragging rights, it’s also an audition of sorts. Forget Thanksgiving, both teams hope Christmas comes early this year in the form of Odell Beckham Jr. The free-agent wide receiver, who played for the Rams last season and was injured in the Super Bowl, is expected to visit both teams after Thanksgiving. 

Best Bet: Giants +8.5 (-110) with Caesars Sportsbook ➜

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New England Patriots at Minnesota Vikings, 8:30 p.m. (NBC)

The Patriots make their first visit to Minnesota since Super Bowl 52. The Patriots lost that game despite Tom Brady throwing for more than 500 yards and 3 TDs. Patriots fans remember this defensive stat: Malcolm Butler only took one snap in that game. The reason why remains a mystery outside One Patriot Place. 

The Patriots and Vikings combined for 6 points on offense Sunday. The Vikings got ransacked at home by the Cowboys 40-3. The Patriots beat the Jets 10-3 because the Jets are, well, the Jets and don't know how to punt the ball with 26 seconds to play in a tie game. The Vikings will score at least 4 points this week. The Patriots might not throw the ball more than 4 times. This line (Minnesota -3) appears a bit deceptive on the Patriots side. 

Best Bet: Over 43.5 Points (-110) with Caesars Sportsbook ➜

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About the Author

Bill Speros for Bookies.com
Bill Speros
Bill Speros is an award-winning journalist and editor whose career includes stops at USA Today Sports Network / Golfweek, Cox Media, ESPN, Orlando Sentinel and Denver Post.
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