Week 2 of the 2022 NFL betting schedule features a staggered Monday night doubleheader with the Buffalo Bills playing host to the Tennessee Titans and the Minnesota Vikings visiting the Philadelphia Eagles. Here's a look at the odds and best bets to back in those games. 

In the first game, the Bills and Titans kick off at 7:30 p.m. on ESPN. Minnesota and Philadelphia begin at 8:30 p.m. on ABC. The overlap is unique in that past ESPN Monday night doubleheaders have had staggered starts that saw the second game begin at 10:15 p.m. on the East Coast. 

The full NFL schedule will be unveiled on Thursday. Other games are expected to be released in the interim. Last week, the NFL announced the dates, teams, and sites for its five international games. NFL odds are available for all games currently on the schedule. 

In the first game scheduled for Sept. 19, the host Bills are -7 at DraftKings Sportsbook, and sit -320 on moneyline. The Titans are +250. The Bills will likely open the NFL season on Thursday, Sept. 8 at SoFi Stadium against the Super Bowl 56 champion Los Angeles Rams. The Bills lost 42-36 in overtime to the Kansas City Chiefs in the AFC Divisional round last season in a game that saw three lead changes and 25 points scored in the final two minutes of regulation. 

The Eagles are 2.5-point favorites at online sportsbooks at home over Minnesota in the second game of the night on Sept. 19. The moneyline has the Eagles at -135, while the Vikings are +115.

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Bills-Titans Meet Again In Regular Season

In the offseason, the Bills focused on defense in the draft, taking Florida cornerback Kaiir Elam with the 23^rd overall pick. They also signed former Titans offensive lineman Rodger Saffold as a free agent. 

This will be the fifth straight season in which the Bills and Titans have played each other. Last season, the Titans stuffed Bills QB Josh Allen on a fourth-and-inches run with less than 30 seconds to play to seal a 34-31 victory. Titans running back Derrick Henry ran for 146 yards in the game, including 76 on a rushing TD.

The Bills are playing host at home on Monday night for the third straight year. They lost 14-10 to the Patriots last December in a frigid affair that saw New England attempt just 3 passes in 49 snaps. This time, the weather should not be a problem. 

The Titans bring back Ryan Tannehill at quarterback despite an offseason full of rumored potential trades. Tannehill threw 3 picks in the Titans’ 19-16 playoff loss to Cincinnati in the divisional round. Tannehill admitted the loss affected him emotionally and underwent therapy in the offseason to help him process the loss and, eventually, learn from it. 

The Bills went 10-7-2 ATS last season, despite finishing 12-7 overall. The Titans were -2 games ATS, going 12-6 overall but just 10-8 vs. the line. 

Week 2 Titans-Bills Prediction:

Even though the Bills are all but certain to face the Rams in Week 1, the extra time off should give them plenty of time to prepare and focus on the Titans. The Bills are +650 favorites at DraftKings and most other books to win Super Bowl 57, while the Titans sit in the middle of NFL pack at +3000. 

The Bills enjoy a win/loss total of 11.5, while the Titans are slotted at 9.5. This disparity should be evident in Week 2, where a wound-up Bills Mafia crowd and Allen’s offense should keep Henry and the Titans off the field long enough for the Bills to cover the one-score spread. 

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Eagles At Home Against Vikings

A revised Eagles offense includes WR A.J. Brown, who flew the coop in Tennessee to join the Eagles. After being traded to Philly for a first-round and third-round pick in the 2022 draft, Brown signed a 4-year, $100 million extension. Of that, $57.22 million is guaranteed.

The Eagles' core of skill players features 5 players all age 27 or under: QB Jalen Hurts (23), DeVonta Smith (23), Miles Sanders (25), Quez Watkins (23), Dallas Goedert (27) and Brown (24). Hurts, like Tannehill, saw his name surface throughout the offseason in potential trade rumors. But he’ll be slinging it in Week 2 – barring injury – this season when the Eagles entertain the always colorful crowd at Lincoln Financial Field. 

Both the Eagles (+3500) and Vikings (+4500) are deep near the back of the pack of potential Super Bowl 57 winners at sports betting apps. The over/under win total for the Eagles is 8.5, while the Vikings sit at 9. Minnesota was +1 ATS, finishing 8-9 outright but 9-8 for spread bettors. The Eagles were nearly even, going 9-9 overall and 8-9-1 ATS. 

The Vikings come to Philadelphia having just missed the postseason last year. WR Justin Jefferson has emerged as the marquee target on offense and is the only wideout in NFL history to have 3,000 yards receiving after just two seasons. 

Week 2 Eagles-Vikings Prediction

Fans in Philly and elsewhere will be eager to see what coach Nick Sirianni and Hurts will do with this bounty of offensive options. Since this game falls in Week 2, the Eagles should have eliminated several mistakes likely made in Week 1. 

This line could well move depending on how well the Eagles perform in their season opener and on how well Hurts appears to have adapted to the options he now has available. For our NFL betting  card, we like the Eagles both -2.5 and -135 on the moneyline, with the expectation that these numbers could swell with a solid performance in Week. 1.  

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