Week 3 of the NFL betting season features a rematch of Super Bowl 56 when the LA Rams visit the Bengals in Cincinnati. Check out our best bets and picks to back for all 16 games right here.

The Rams and Bengals have taken divergent paths since that February 2022 showdown at SoFi Stadium. 

The Rams won 23-20 but the Bengals grabbed the backdoor cover as 4.5-point underdogs. The Bengals never stopped in 2022. They went 12-4 straight up and ATS during the regular season. The Bengals lost and failed to cover at +1.5 against the eventual Super Bowl champion Chiefs 23-20 in the AFC title game after splitting the first two rounds against the line. 

The Rams, meanwhile, dissolved. The defending champions finished 5-12 overall and 6-10-1 ATS.

The Bengals stocked up this offseason to fix what failed them against Kansas City. A buff Joe Burrow and his teammates are a strong value in NFL futures betting markets for both the AFC and Super Bowl. Heading into the season, Cincinnati was +550 to win the conference and +1200 to win its first-ever NFL title. 

The Bengals' over under betting total for wins is set at 11.5.

The Rams, on the other hand, have nothing but upside. Matthew Stafford, Aaron Donald and Cooper Kupp will be working with cast of young, and untested talent. The win total for the Rams has been set at 6.5. 

Week 3 begins with a potential NFC playoff preview as the New York Giants visit San Francisco on Thursday night. FOX has the late national game, which will feature a painful choice between the Cowboys at Cardinals or Bears at Chiefs. Most of the nation will get the Chicago-KC game. The Steelers and Raiders try to recreate 1972 Sunday night in Las Vegas. 

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NFL Week 3 Picks – Super Bowl 56 Rematch 

Here are our Week 3 best bets to back. Things are subject to change.

Oddsmakers on betting apps have now set betting lines for Week 3 matchups. Here are our NFL Week 3 picks and best bets:

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Thursday, September 21

New York Giants at San Francisco Giants, 8:15 p.m. (Prime) 

Game	Bet	Pick	Best Odds
Thursday Sep 21, 08:15pm					New York Giants NYG San Francisco 49ers SF	Spread	New York Giants NYG	+5 -110

The 49ers were 9-1 ATS as home underdogs last season. The Giants, meanwhile, were 7-2 as road dogs. There isn’t much an edge here either way. By Week 3, the 49ers should have some stability at both QB and within their offense overall. The Giants are the Giants and offer no surprises. Ball control and defense. Don’t expect this line to sit at five through kickoff. We’ll revisit this when the total is offered and will lean toward the under. 

Best Bet: Giants +5 (-110) at DraftKings

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Sunday, September 24

Indianapolis Colts at Baltimore Ravens, 1 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 01:00pm					Indianapolis Colts IND Baltimore Ravens BAL	Spread	Baltimore Ravens BAL	-8 -110

The Ravens need to feast on opponents like the Colts if they want to keep up with the Bengals in the AFC North. Not even the Colts know how developed their offense will be by Week 3. Meanwhile, the Ravens and Lamar Jackson are tied together through the 2027 season. The Ravens covered just once in 7 tries as home favorites last season. This line will likely move in their favor as the game approaches. Take the 7 while you can. 

Best Bet: Ravens -7 (-110) at DraftKings

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Tennessee Titans at Cleveland Browns, 1 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 01:00pm					Tennessee Titans TEN Cleveland Browns CLE	Spread	Tennessee Titans TEN	+4 -110

The total on this game should be in the high 30s. And that may be too generous. The early line is a bit too generous for Cleveland, as 4.5 points is much closer in your rearview mirror to 7 than it looks. We’re going to hold our nose, for now, and take those points. This matchup could be revisited depending on the total. 

Best Bet: Titans +4.5 (-110) at DraftKings

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Atlanta Falcons at Detroit Lions, 1 p.m. (FOX)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 01:00pm					Atlanta Falcons ATL Detroit Lions DET	Spread	Detroit Lions DET	-5 -110

This is an opportunity to take advantage of any early line. The Lions are just 5-point favorites at home. Last year, the Lions were 7-2 ATS at home and 3-1 as home favorites. They entered the season with the best winning percentage against the spread of any NFL team (regular and postseason) over the past two years combined. If Detroit is as good as advertised, this line may hit double-digits by kickoff. Another Katy Perry game. “Roar.” 

Best Bet: Lions -5 (-110) at DraftKings

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New Orleans Saints at Green Bay Packers, 1 p.m. (FOX)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 01:00pm					New Orleans Saints NO Green Bay Packers GB	Moneyline	New Orleans Saints NO	-105

The Packers continue to rebuild behind Jordan Love. Given the tattered state of the NFC South, the Saints are a potential playoff team. Derek Carr’s offensive will be in gear by Week 3. Even though this is an outdoor road game, the weather in Wisconsin in late September often borders on perfect. That will be a non-factor in this one. 

Best Bet: Saints Moneyline (-105) at DraftKings

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Houston Texans at Jacksonville Jaguars, 1 p.m. (FOX)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 01:00pm					Houston Texans HOU Jacksonville Jaguars JAX	Spread	Houston Texans HOU	+8 -110

The most intriguing feature in this AFC South matchup is that it will air on FOX. The NFL this year divorced the conferences from their traditional network partners. So non-prime-time, intra-conference AFC games will no longer air exclusively on CBS. And non-prime-time, intra-conference NFC games will no longer air exclusively on FOX. The Jaguars failed to cover last year in their three changes as home favorites. These teams split outright and ATS, with the Jaguars losing 13-6 at home in Week 5.

 Best Bet: Texans +7 (-110) at DraftKings

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Denver Broncos at Miami Dolphins, 1 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 01:00pm					Denver Broncos DEN Miami Dolphins MIA	Spread	Miami Dolphins MIA	-3.5 -110

Denver coach Sean Payton and QB Russell Wilson receive some early respect from oddsmakers, as they are just 3.5-point underdogs. The Dolphins are loaded for an AFC East/playoff run. More relevant here, a 1 p.m. South Florida kick on September 24 means an excess of sun, heat and humidity for the Mile High visitors, assuming there isn’t a tropical storm or hurricane on the scene. Grab this one at Miami -3.5 while you can.

Best Bet: Miami -3.5 (-110) at DraftKings

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LA Chargers at Minnesota Vikings, 1 p.m. (FOX)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 01:00pm					Los Angeles Chargers LAC Minnesota Vikings MIN	Spread	Los Angeles Chargers LAC	-1 -110

The Vikings are a surprising 1.5-point home underdog in this inter-conference matchup. Both teams made the playoffs only to get bounced in the Wild Card Round. The Chargers carry the slight edge in terms of projected win totals. They are -110 to go over 9.5 wins. The Vikings are -130 to over 8.5 wins. But Minnesota flailed at home, going 4-6 ATS last year. The Chargers were 7-3 vs. the line on the road and 4-2 as road favorites. We’ll go with the road favorites for now. 

Best Bet: LA Chargers -1.5 (-110) at DraftKings

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New England Patriots at New York Jets, 1 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 01:00pm					New England Patriots NE New York Jets NYJ	Moneyline	New England Patriots NE	+150

The Patriots have beaten the Jets 14 straight times, while covering in the past five matchups. Can Aaron Rodgers finally end Gang Green’s slide vs. The Hoodie? There are a handful of games that Bill Belichick has been game-planning for since April. This is one. 

Best Bet: Patriots Moneyline (+150) at DraftKings

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Buffalo Bills at Washington Commanders (For Now), 1 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 01:00pm					Buffalo Bills BUF Washington Commanders WAS	Spread	Buffalo Bills BUF	-5 -110

The Bills badly underperformed against the line last season, going 8-9-1 ATS despite finishing 15-4 (including the postseason). This line is a bit tight considering the preseason win projections of each team. The Bills are only a 1.5-point favorite on a neutral site. Buffalo’s projected win total is 10.5, while Washington’s is just 6.5. This one could open up given that this could well have a “home” feel for Buffalo.

Best Bet: Bills -4.5 (-110) at DraftKings

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Carolina Panthers at Seattle Seahawks, 4:05 p.m. (CBS)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 04:05pm					Carolina Panthers CAR Seattle Seahawks SEA	Spread	Seattle Seahawks SEA	-4 -110

Geno Smith and Pete Carroll won’t be surprising anyone this season. This is a good road test for the Panthers emerging offense. Seattle went just 1-4 as home favorites last season. This line could easily move to -7 depending on how just how far Carolina as developed with rookie and No. 1 overall pick Bryce Young at QB. We will revisit this once the total is set. Anything over 40 points is must-bet under. 

Best Bet: Seahawks -4 (-110) at DraftKings

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Dallas Cowboys at Arizona Cardinals, 4:25 p.m. (FOX)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 04:25pm					Dallas Cowboys DAL Arizona Cardinals ARI	Spread	Dallas Cowboys DAL	-7 -110

The Cowboys open against the Giants and Jets. Those two bites out of the Big Apple could well leave Dallas 0-2 heading to what would be a must-win against the woeful Cardinals. And we mean woeful. 

Best Bet: Cowboys -6.5 (-110) at DraftKings

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Chicago Bears at Kansas City Chiefs, 4:25 p.m. (FOX)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 04:25pm					Chicago Bears CHI Kansas City Chiefs KC	Spread	Chicago Bears CHI	+9.5 -110

The Chiefs have been absorbing significant amounts of cash during the past few seasons. Last year, they were 3-5-1 ATS as home favorites and 8-11-1 overall on the line through the Super Bowl. They did cover in that one. KC only covered twice in its first six games last season. 

Best Bet: Bears +9.5 (-110) at DraftKings

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Pittsburgh Steelers at Las Vegas Raiders, 8:20 p.m. (NBC)

Game	Bet	Pick	Best Odds
Sunday Sep 24, 08:20pm					Pittsburgh Steelers PIT Las Vegas Raiders LV	Spread	Las Vegas Raiders LV	-110

Tom Brady. Josh McDaniels, Jimmy Garoppolo. Chandler Jones. The Las Vegas Patriots play host to their long-time nemesis Pittsburgh. The Raiders are grossly undervalued on this early line. Vegas won’t blow anyone out, but McDaniels will do his best to make sure Garoppolo keeps the offense on the field. If that doesn’t work, Brady can always suit up.

Best Bet: Raiders -1.5 (-110) at DraftKings

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Monday September, 25 

Philadelphia Eagles at Tampa Bay Buccaneers, 7:15 p.m. (ABC)

Game	Bet	Pick	Best Odds
Monday Sep 25, 07:15pm					Philadelphia Eagles PHI Tampa Bay Buccaneers TB	Spread	Philadelphia Eagles PHI	-7 -110

The Eagles should be past whatever post-Super Bowl-defeat hangover they may have endured in Weeks 1 or 2. Tampa Bay was the worst team against the line last year with Brady. The Buccaneers failed to cover all 4 times they were underdogs. This is their biggest number as a home underdog since Week 2 of the 2019 season, before they signed Brady. This crowd will have a decided pro-Philly slant. If this line moves over 7, back the home team. 

Best Bet: Eagles -6.5 (-110) at DraftKings

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LA Rams at Cincinnati Bengals, 8:15 p.m. (ESPN)

Game	Bet	Pick	Best Odds
Monday Sep 25, 08:15pm					Los Angeles Rams LAR Cincinnati Bengals CIN	Spread	Cincinnati Bengals CIN	-8 -110

These teams have taken divergent paths since the Rams beat the Bengals 23-20 in Super Bowl. Cincinnati nabbed a backdoor cover as 4-point underdogs in that game. The Bengals would well be 2-0 and looking for some payback at home in front of a well-lubricated home crowd. This could get ugly early. We’ll revisit this game when the totals are set. 

Best Bet: Cincinnati -7 (-110) at DraftKings

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