Best NFL Week 2 Parlays: Lamar Jackson, Joe Burrow & More

By Adam Thompson Sep 11th, 2025 1:55 PM EDT

Baltimore Ravens quarterback Lamar Jackson (8) Mandatory Credit: Mark Konezny-Imagn Images

What we learned about the 2025 NFL season in Week 1 is it can be very tough to go against oddsmakers.

Teams getting over 50% of public bets in Week 1 went 3-13 ATS, a paltry 18.8%.

Favorites and the Under both dominated in Week 1. The Favorites went 13-3 straight up for the second Week 1 in a row, and the Under was 12-4, tied for the lowest mark in 25 years.

Bookies.com NFL handicapper Adam Thompson has his finger on the pulse of the NFL. He hit on 62.5% of his best bets in Week 1 and has hit on a whopping 60.2% of his NFL best bets five years running and is geared up for the 2025 NFL season.

Here are his two NFL parlays to back on the best betting apps for Week 2 of the 2025 NFL season:

Intriguing NFL Week 2 Parlays:

NFL Parlay	NFL Odds
The QB Party	+891 at FanDuel
Home By A Score	+610 at BetMGM

Odds are current as of publication but subject to change. For the most updated NFL odds, please check the betting apps.

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The “QB Party” Parlay

Leg 1: Lamar Jackson, Over 216.5 Pass Yards (-112)

According to Pro Football Focus, Jackson was the highest-graded QB vs. single-high coverage (one safety), and the Browns run that defense more than any other team. Jackson has thrown for 217-plus yards in two of the last three vs. Cleveland.

Leg 2: Joe Burrow, over 276.5 Pass Yards (-115)

In a similar trend, Burrow ranks No. 2 in passing against zone defenses, and the Jaguars last year were No. 4 in zone usage. Burrow has faced Jacksonville only twice, but threw for 300-plus yards in both instances.

Leg 3: A.J. Brown, Anytime TD (+180)

The Eagles’ top receiver managed just one catch for eight yards vs. the Cowboys in Week 1. Expect a more concentrated effort to get Brown the ball more often. The Chiefs gave up three passing TDs to the Chargers last week, all to outside WRs.

The “Home By A Score” Parlay

Leg 1: Dolphins -1.5 over Patriots

Miami was humiliated by the Colts in Week 1, but there’s too much talent on the roster, and Tua Tagovailoa is 7-0 ATS all-time vs. New England. The Pats’ banged-up secondary is in for a long afternoon in the heat.

Leg 2: Steelers -2.5 over Seahawks

Both teams played games decided in the final minute in Week 1; the Steelers edged the Jets, the Seahawks fall at home to the 49ers. Pittsburgh’s defense, notably, is due to play much better, and Aaron Rodgers has seemingly found his path to success.

Leg 3: Cardinals -6.5 over Panthers

Carolina’s defense might be the worst in the NFL, and if the offense can’t keep up, expect blowouts. The lines will adjust eventually, but we’ll take Kyler Murray laying under a TD. Fun fact: Bryce Young is 0-6 SU (1-5 ATS) in games that don’t start at 1 p.m. ET.

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About the Author

Adam Thompson

More About Adam

Long established as one of the nation's premier handicappers, Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine & CBSSports.com. He specializes in the NFL and MLB, where he's hit on well over 60% of his picks the past five years. Adam's NBA and horse racing picks have also produced consistent, major winners over the years.