The most anticipated game on the NFL Week 8 schedule kicks off on Thursday night, as Kyler Murray and the unbeaten Arizona Cardinals get a big test when they host Aaron Rodgers and the Green Bay Packers. The Cardinals (7-0) are the only team remaining without a loss, while the Packers (6-1) haven’t fallen since Week 1.

The winner makes a statement and holds a head-to-head tiebreaker that may come into play in the postseason. Sportsbooks have Arizona as a four-point home favorite, this after most betting sites and some top betting apps opened the game at Cardinals -3.

Check out the latest Packers vs. Cardinals odds ahead of the matchup on Thursday Night Football.

Packers vs. Cardinals Key Matchups

Kyler Murray vs. Packers Pass D: Murray averages 9.0 yards per pass attempt, the No. 3 mark in the NFL. The Packers’ defense is allowing just 6.2, the fifth-lowest average.

Aaron Jones vs. Cardinals Front 7: The Cardinals have allowed just one TD in seven games to opposing running backs. Jones has just one score since Week 3.

Packers WRs vs. Arizona DBs: While the Cards have allowed just one TD to RBs and none to tight ends, the nine TDs to receivers is the sixth most. Davante Adams’ status is in question (Covid protocols); that would be a huge hole to fill as no other receiver on the team averages more than 26 ypg receiving.

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5 Key Packers vs. Cardinals Stats

4.9: The average yards allowed per rush by the Packers’ defense, the third-highest mark in the league.

5.0: The average yards allowed per rush by the Cardinals, the second-worst. Only the Chargers allow more yards per carry than Arizona and Green Bay.

5.8: Yards per carry for Cardinals starting RB Chase Edmonds, second among all regular RBs. Backup James Conner was averaging 2.7 ypc through five games but 5.2 over the last two.

84.5: The QB Rating allowed by the Cardinals’ defense this season, fourth-best in the NFL. Aaron Rodgers’ 108.2 QB Rating ranks fifth.

233: The career-most yards passed by Rodgers in four games vs. the Cardinals. Only once in those four games has he managed more than one TD.

Packers vs. Cardinals Weather Forecast

Thursday night will be a balmy 87 degrees during the day in the greater Phoenix area, with sun and no chance of rain in the desert. The low in the evening should drop to the 60s, so there is a chance the retractable roof at State Farm Stadium will be open for the prime-time game. If it’s closed, the temperature is always set at 78 degrees.

Packers vs. Cardinals Player Props

Aaron Rodgers, Under 258.5 Pass Yards

Odds: -115 at DraftKings

This total would be 26 yards higher than Rodgers has even thrown in four regular season games vs. Arizona. That he won’t have his top two WRs, and that the Cardinals are top five vs. the pass all season, makes the challenge even more daunting.

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Christian Kirk, Over 45.5 Receiving Yards

Odds: -120 at DraftKings

Kirk has over 46 yards receiving in five of Arizona’s seven games; in fact he has 50-plus in those five instances. The Packers, without star CB Jaire Alexander, will be forced to focus on DeAndre Hopkins. That opens things up for Kirk, who is second to Hopkins in targets, receptions, yards and TDs.

Aaron Jones, Over 13.5 Rush Attempts

Odds: -140 at DraftKings

Prior to just seven carries last week vs. Washington, Jones had at least 13 tries in five consecutive Packers games. With no receivers and facing a Cards defense that ranks far worse vs. the run (18th) than vs. the pass (4th), Jones should, at worst, be back to his usual 14-18 carries per game. At best, he’s closer to 20.

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Packers vs. Cardinals Moneyline

The Cardinals are -200 on the moneyline, meaning a $200 wager would win $100 in profit. On the other side, the Packers are at +170 ($100 wins $170 in profit).

We’ve all seen what Aaron Rodgers can do, even with the deck stacked against the rest of his team personnel-wise. But to back the Pack here seems riskier than usual. Breaking down every major statistic reveals an edge for the Cardinals. Green Bay’s decimated secondary handled itself fine against Taylor Henicke in Week 8, but Kyler Murray presents an entirely different challenge, as do his targets. Going against Rodgers at -200 is a risk, but we can’t take the Packers either.

Packers vs. Cardinals Point Spread

When it comes to NFL spreads, everyone who has backed these teams against the spread has flourished. Both Arizona and Green Bay are 6-1 against the spread this season. Only the Cowboys, at 6-0, have been better.

Something has to give on Thursday night, and it’s likely to be the Packers’ defense. They could be without three of four secondary starters and there are injuries in the linebacking corps as well. Arizona has arguably been better on the road than at home this season, but the injuries might be too much to overcome for the Packers defense, especially vs. a pick-your-poison Arizona offense that’s top 10 in the run and the pass, and No. 4 in scoring.

Those looking for a Thursday night side as part of your NFL picks should consider laying the points with the home Cardinals. You can get the Cardinals -4 at DraftKings.

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Packers vs. Cardinals Totals

The Over/Under for Thursday Night Football is 52.5 points. Only the Sunday night game between the Cowboys and Vikings is higher (54). But is it too high? While these teams average a combined 56.1 ppg so far, they’re allowing just 37.2. The Cardinals rank No. 1 in fewest points allowed.

Rodgers has shown time and again he can dismantle the best defenses. Murray is showing that as well. The run games are humming, the pass attacks are elite, and each team has injury issues on the defensive side. Consider the Over here as part of your NFL betting Week 8 lineup. You can get Over 52.5 at FanDuel.

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