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San Francisco 49ers vs Philadelphia Eagles Odds, Picks & Predictions

Adam Thompson for Bookies.com

Adam Thompson  | 

San Francisco 49ers vs Philadelphia Eagles Odds, Picks & Predictions

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Unlikely star QB Brock Purdy is just one win from taking the San Francisco 49ers to the Super Bowl, but he faces his toughest test yet when the Niners take on Jalen Hurts and the Philadelphia Eagles in the NFC Championship on Sunday at Lincoln Financial Field. 

Purdy, the final pick in the 2022 NFL Draft, is 7-0 as the starting QB of the 49ers since Jimmy Garoppolo was injured. The Niners are averaging 32.6 ppg in his starts and he has the 49ers on the cusp of a second Super Bowl berth in four seasons. The Eagles are the No. 1 seed in the NFC, led by an offense and defense that both rank in the top three in the league. 

Philadelphia is a slim 2.5-point favorite at NFL betting sites in the latest 49ers vs. Eagles odds. The Over/Under is at 45.5 points on sports betting apps

Bookies.com NFL handicapper Adam Thompson – focused on hitting over 60% of his NFL picks for a fourth-consecutive season – reveals his best bets and props for the NFC Championship. 

49ers vs. Eagles Point Spread Pick

People wondered which team would rattle the unflappable Brock Purdy. The Cowboys got to him and made him uncomfortable. He didn’t play poorly, but the 19 points scored was the first time the Niners finished with under 37 points in a month. Philly is like Dallas, but better in just about every way, including in harassing QBs. 


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The Eagles are 15-1 when Jalen Hurts plays. Only once since Week 1 in those games did the team allow over 22 points. As strong as the 49ers have been, they have weaknesses, notably allowing big plays on defense. 

Philly is 7-2 ATS at home with Hurts. Only twice has Philly been favored by under five points at home this season. They won the games by 25 and 17. Lay the 2.5 points on the Eagles to win and cover. 

49ers vs. Eagles Over/Under Best Bet

Philadelphia ranks No. 2 in fewest pass yards allowed, fourth in most INTs and had 15 more sacks than any other team. And now the Eagles have the gameplan on how to slow down Purdy and the Niners, thanks to their struggles against Dallas. 

As for San Francisco’s defense, it doesn’t get much better, either. The team is allowing 14.9 ppg during its current 12-game win streak. Philly’s offense ranks top 10 in both rushing and passing, but it isn’t hard to imagine one or both of these teams finishing under their usual. The Under has hit in the last four meetings. Lay it on the Under for the NFC showdown. 

49ers vs. Eagles Moneyline Pick

There’s a lot to like about the 49ers. They’ve won 12 in a row and rank No. 1 in total defense. Purdy has played above his weight class. They have weapons at every level to put pressure on Philly’s defense. 

But the Eagles defense is too ferocious, its offense too balanced. Only the Eagles and Bills ranked in the top 10 in both rushing and passing. San Francisco averages about five fewer points per game on the road. Philly’s homefield advantage should be tangible. The Eagles can be had at -140 on the moneyline. It’s worth a sprinkle, though we prefer the small spread.

Best 49ers vs. Eagles Player Props

A.J. Brown, Over 68.5 Receiving Yards

Odds: -115 at BetMGM Sportsbook

Brown had just three catches and 22 yards last week, though the Eagles won 38-7 without big-time production. The previous four weeks he’s gone over 95 yards and has had at least 70 yards in six straight, averaging 110.8 ypg. 

The Niners, as great as their defense is, ranks 27th in yards allowed to WRs. Brown should see favorable matchups. The team is 6-0 when he gets 10 targets. 

Jauan Jennings, Under 2.5 Receptions

Odds: -180 at DraftKings Sportsbook

The 49ers WR hasn’t had three receptions in a game for five straight weeks. The last five games he’s played that Deebo Samuel also played, he’s had two receptions three times and one catch the other two. 

Big play potential has his receiving yards varying wildly, but Brock Purdy has so many other Pro Bowl-level weapons out there, Jennings has been lost in the shuffle. Don’t expect an uptick in production vs. the No. 2-ranked pass defense. 

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About the Author

Adam Thompson for Bookies.com
Adam Thompson
Long established as one of the nation's premier handicappers, Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine & CBSSports.com. He specializes in the NFL and MLB, where he's hit on well over 60% of his picks the past five years. Adam's NBA and horse racing picks have also produced consistent, major winners over the years.