With all their injuries to key players on offense, the Titans are still atop the AFC South. The Steelers are at the bottom of the competitive AFC North but still have their eyes set on the postseason. We see sportsbooks giving the slight edge to the Titans with little-to-no home-field advantage for the Steelers.

Pittsburgh is not alone as an AFC South home dog, as two other NFL spreads have both Baltimore and Cleveland taking points at home. Unlike a bunch of other games – including the Browns – bettors have a clearer picture of health for any NFL picks that jump out in this game.

Since the tie with the Lions, the Steelers have dropped three of four games, including last week. The Titans dropped two straight before their bye week, then promptly came out and suffocated the Jags. A scoring offense versus a defense that pressures the QB is one NFL betting matchup to keep an eye on here, as the Steelers defense will need to get to Ryan Tannehill or they will be looking up at the scoreboard all night.

Take a look at Steelers vs Titans odds, injury report, betting lines and more.

Titans vs Steelers Key Matchups

Steelers Pressure vs Titans OL: The Steelers will have their chances in getting to Tannehill. The Titans QB has been sacked just over three times per game. Already without Derrick Henry, the Titans can’t afford to have their passing game limited.

Titans Rush O vs Steelers Rush D: The Titans will still try and run the ball with D'Onta Foreman and even some Tannehill. Bad news for the Steelers as they enter with the league’s 30th-ranked defense against the run.

QBs vs Mistakes: Let’s not make this too confusing as turnovers are already a key factor in a team winning or losing, but in this case it’s everything. Neither team has the capability to really come back. First QB to two mistakes loses the game.

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Titans vs Steelers Key Stats

30th: It’s fairly easy to run the ball on the 30th-ranked rush defense in Pittsburgh. Imagine how bad this would be if Henry were actually healthy.

37: This is the number of times opposing defenses have sacked Tannehill, in only 13 games. Don’t expect the Steelers – even without TJ Watt – to slow down in intensity.

4.4: While he’s no ‘King’, Foreman has still carried the ball for an average of 4.4 YPC. We know how bad the Steelers run defense is, so the Titans may see a big day out of Foreman.

28th: The Steelers have one of the best and brightest young stars at the RB position in Najee Harris but the team is still near the bottom of the league in rushing. Pittsburgh has a bad OL and it’s been easy to take their run offense out of the game.

5th: The Titans' numbers are a little off from the eight games Henry ran all over teams, but they are still 5th in the NFL in Rushing YPG.

2nd: The Titans have the second-best rush defense in the NFL and should swallow up any attempts by the Steelers.

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Titans vs Steelers Moneyline

The Titans are the play here as betting sites are giving us a break with a -120 play on the moneyline. The Steelers aren’t getting enough of a return with only an even-money play, especially with how bad their run game is and how volatile their passing game can be.

The Titans come off a necessary beatdown of the Jags and should be back on track as they are healthier at the WR position. Julio Jones back in the fold should be a difference-maker for Tannehill and the Titans offense.

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Titans vs Steelers Point Spread

Nothing changes here with the spread as the return is just 10 points better on the juice. The play is the same and if bettors want an increased return, then just take the Titans on the spread. Pittsburgh is 5-8 ATS and 3-3 ATS over their last six games. They secured that back-door cover against the Chargers, just one week after tying the Lions.

Even when they cover, it’s due to more outlier circumstances. The Titans are still above .500 with an impressive 8-5 record ATS. Feel free to play both Titans plays and double down your return. You can get the Titans -2 (-110) at BetMGM.

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Titans vs Steelers Point Total

The total is low for Titans games – even with last week’s shutout – but the Steelers present a problem for the over, especially at home. The under is 8-5 this year for Pittsburgh as they have a knack for keeping games low. Longer drives that rely on Harris getting the ball – in the air or on the ground – help keep games on the lower side.

But the Titans should be able to force the Steelers into throwing more, even without being up by a big margin. The Titans have hit the over in 7 of their last 8 games, and should be the reason this one goes over 42.

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