Week 10 of the 2024 College Football season offers up some traditional and not-so-traditional conference matchups, several of which will determine the fate of teams hoping for a shot at their conference title, or a spot in the college football playoff.

Bettors will be taking a deep look at college football odds with serious interest. College football betting sites have posted lines for dozens of games this week.

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In the SEC, Florida and Georgia meet in Jacksonville in what used to be dubbed the “World’s Largest Cocktail Party.” Both teams are coming off a bye. In the ACC, Louisville visits Clemson. In the Big Ten, Oregon heads east to The Big House in Ann Arbor, and Penn State rolls into Columbus. 

Opportunities abound all week and weekend on sports betting apps. For instance, BetMGM, FanDuel and ESPN BET have posted a healthy slate of futures concerning the college football playoff and season awards. 

Take a look at our favorite college football picks for Week 10 of the 2024 season. Any team rankings are from the latest AP Top 25 Poll.

College Football Week 10 Best Bets To Back Today

Saturday, November 2 
(4) Ohio State at (3) Penn State, 12 p.m. (FOX) 

Buzz: Ohio State needs a win to keep its hopes alive for both a spot in the Big Ten title game and spot in the college football playoff. A 2-loss Buckeyes team won’t cut it this season, even with those losses coming to Penn State and Oregon. The math doesn’t work given that Ohio State would have been beaten by the loser of the Big Ten title game. The Lions roared at Camp Randall Stadium in Week 9. ESPN Analytics gives Ohio State a 61% to win. The number moved away from Penn State despite its dominant win and Ohio State's struggle at home against Nebraska. 

Best Bet: Penn State +3.5 (-110) at FanDuel

Saturday, November 2 
Duke at (6) Miami, 12 p.m. (ABC)

Buzz: The ACC may only get one team in the college football playoff, especially if the winner of the ACC title game is undefeated. That’s the reality facing Miami. The Canes will need to not only run the table but run up the score against the ACC opponents, perhaps to even get a spot in the title game itself. Duke will be the latest victim here. In addition to facing the Canes’ defense and QB Cam Ward, Duke will be dealing with the heat and humidity of South Florida in November. The Blue Devils nearly knocked off No. 22 SMU on Saturday but fell victim to kicking woes in a 28-27 loss. ESPN Analytics gives Miami a 90.7% chance to win. But the 8-0 Canes struggled to hold their cover against FSU and have covered just 4 times this season.

Best Bet: Duke +20.5 at FanDuel

Saturday, November 2 
(1) Oregon at Michigan, 3:30 p.m. (CBS)

Buzz: The Ducks continue to quack up the rest of the Big Ten in their first season in the conference. Oregon has been dominant at home and pitched a shutout at Purdue and followed that by a 38-9 curb-stomping of then No. 20 Illinois. Oregon has scored 30 or more points in 7 straight games after Week 1. The Ducks here have an opportunity to knock off the defending national champions in the Big House. Oregon isn’t afraid of playing away from home. A 2+ TD win in Ann Arbor would ice the Ducks’ spot at No. 1 in the national polls until the B1G title game and/or its first loss. The  Ducks and Wolverines are 6-10 on the line this season through Week 9. In cases like these, lean into the quality team, especially 10 games into the season. ESPN Analytics gives Oregon a 77.8% to win.

Best Bet: Oregon -13.5 (-118) at FanDuel

Saturday, November 2 
Texas Tech at (10) Iowa State, 3:30 p.m. (ESPN) 

Buzz: The Cyclones come off a bye and are tied atop the Big 12 after surviving a scare against UCF. That was their sufficient scare. Iowa State had allowed just 11 points per game before that 38-35 win over UCF. Its defense will be well rested and prepared for Tech’s run-first attack. Meanwhile, Texas Tech is coming off a crushing 35-24 loss to Texas Christian this week. Iowa State can score - and will score - against Tech. That's the difference here. Since Week 1, the Cyclones are 4-1 ATS on double-digit lines. ESPN Analytics gives ISU an 81.5% to win.

Best Bet: Iowa State -12.5 (-110) at FanDuel

Saturday, November 2 
Arizona at UCF, 3:30 p.m. (FS1) 

Buzz: Hold your nose. These 2 teams have lost 9 straight games combined. Arizona has lost 4 straight and was down 31-13 before a pair of garbage-time TDs in its 31-26 loss to West Virginia in Week 9. This trip will be their longest of the year – 3569.52 miles round trip – crossing 3 time zones each way thanks to Daylight Savings Time. The Wildcats may also find something else unique in their first visit to the Sunshine State – humidity. Teams that travel to Florida from higher and drier climes often find themselves dealing with dehydration and exhaustion issues late. The forecast calls for rain early in the day, and lots of humidity later on in the afternoon. UCF may start redshirt freshman QB Dylan Rizk, who came in during the 4th quarter of UCF's big loss to BYU and led 2 scoring drives in the fourth quarter. Can you say "Backyard Football?" ESPN Analytics gives UCF a 72.5% chance to win. 

Best Bet: Over 57.5 Points (-110) at DraftKings

Saturday, November 2 
Florida vs. (2) Georgia (at Jacksonville), 3:30 p.m. (ABC)

Buzz: We’ll still call it “The World’s Largest Cocktail Party.” Florida and Georgia resume hostilities in Jacksonville. Both teams are coming off the bye. Georgia’s defense wrecked Texas in Week 8. The Dawgs are sitting in the CatBird seat in the SEC and will be in the conference title game if they win out. The Gators have saved Billy Napier’s job with wins over UCF and Kentucky, and a loss to Tennessee in overtime. A Georgia rout here won’t be catastrophic in that sense. The Gators can score – but not against this Georgia defense. Any sort of running game by the Dawgs could open things up for Carson Beck and translate into a rout in the 2^nd half. But the Dawgs have woofed against the spread – going just 2-5 ATS in 7 games. ESPN Analytics gives ISU an 82.2% to win. But we’ll give the Gators the edge to cover on this number. 

Best Bet: Florida +17.5 (-110) at DraftKings

Saturday, November 2 
(16) Kansas State at Houston, 3:30 p.m. (FOX)

Buzz: The No. 16 Wildcats hit the road after rallying for a 29-27 win over Kansas. Will they face a letdown this week after beating their biggest rival. Doubtful. The 2 invites to the Big 12 title game and the resulting college football spot that go to the winner remain up for grabs. The 7-1/4-1 Wildcats need to win out after losing to BYU. They're averaging 34 points per game, compared to 17.1 from Houston. KSU has won 4 straight and close out the season against Iowa State. ESPN Analytics gives Kansas State an 84.5% to win.

Best Bet: Kansas State -12.5 (-110) at FanDuel

Saturday, November 2 
Louisville at (9) Clemson, 7:30 p.m. (ESPN)

Buzz: Clemson holds the edge in the ACC race – for now – by virtue of its schedule. The Tigers are 5-0 in the conference after rolling through Virginia 48-31 in Week 9. They have played and won at least more games than their closest competitor - Miami. But their ACC schedule gets tougher starting this week. They visit Virginia Tech and close the ACC schedule out at No. 19 Pitt. ESPN Analytics gives Clemson a 78% to win. This is really a 2-touchdown line disguised as 10.5 points. 

Best Bet: Clemson -10.5 (-110) at DraftKings

Saturday, November 2 
Kentucky at (7) Tennessee, 7:45 p.m. (SEC Network) 

Buzz: The Vols are on the bye after a dominant win at home over Alabama. Kentucky faces Auburn in Week 9. The Vols have begun to use their depth on defense to smother opponents. Kentucky lost to Florida by 28 points, while the Vols knocked off the Gators in OT. Tennessee needs to both run the table in the SEC and continue to stuff the ballot box when it comes to point differential against common opponents. One of these 3 teams will miss the SEC title game – Tennessee, Georgia, and Texas. All 3 play Kentucky this season. Kentucky is losing steam, having lost 3 straight, including 24-10 to Auburn in Week 9. ESPN Analytics gives Tennessee a 90.1% to win.

Best Bet: Tennessee -15.5 (-110) at DraftKings