Another college football betting season is coming to a close, but we’ve still got more bets to make with several conference title games up in the air and the CFP picture remaining fluid.

Georgia saw its college football playoff odds improve for the third straight week, moving from -120 to -140 to repeat as national champs. Ohio State is the only other school listed shorter than 10-1, with +230 odds – Michigan is third at +1000 and TCU is next at +1800.

All eyes will be on Columbus Saturday, where Michigan and Ohio State are set to square off with a trip to the Big Ten title game and potential CFP spot at stake. Ohio State is favored by just more than a touchdown on betting apps, one year after the Buckeyes were upset by the Wolverines in Ann Arbor.

We’re also looking at additional conference title games to sort out in the Pac 12 and the Big 12 as we enter the home stretch of the college football season entering Week 13. 

College Football Week 13 Odds

Let's take a look at the latest college football odds for select games in CFB Week 13 of the 2022 season. Don't forget to shop around at sportsbooks and on available betting apps for the best price and college football week 13 lines.

And don't forget to keep reading down this article for our best college football picks for Week 13.

College Football Week 13 Best Bets

Here's a look at our college football week 13 best bets, including our favorite picks for Michigan vs. Ohio State and Auburn vs. Alabama.

Mississippi State at Ole Miss, Nov. 24, 7 p.m. ET

Bragging rights are on the line Thanksgiving night in Oxford. The SEC title game is already set, but the Egg Bowl always delivers the drama. The Rebels are slight favorites and coming off back-to-back losses to Alabama and Arkansas that ruined any conference championship hopes. The Bulldogs are coming off a blowout win over East Tennessee and looking to avoid a third straight loss to the in-state rivals.

We’re expecting a big game from Bulldogs quarterback Will Rogers, who’s thrown for nearly 3,500 yards with 32 touchdowns and just five interceptions on the season. The Rebels have given up some big plays in recent weeks and the Bulldogs secondary is strong enough to contain this Ole Miss attack. And things always tend to get weird in this rivalry game. 

The Pick: Mississippi State +2.5 

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North Carolina State at North Carolina, Nov. 25, 3:30 p.m. ET

The Tar Heels booked their ticket to Charlotte two weeks ago, clinching a date with Clemson in the ACC Championship after winning at Wake Forest. But they didn’t respond with a championship mindset in a stunning loss to Georgia Tech last week. Now they get one final tune-up against a Wolfpack team that is regressing big time, with back-to-back losses against Boston College and Louisville.

This is an interesting clash of styles, with a strong Wolfpack defense taking on a Tar Heels offense that wants to go 100 mph at all times. The over-under set in the mid-50s suggests oddsmakers believe North Carolina State will have some success slowing things down, as do we. The Wolfpack has held opponents under 400 total yards in all but one game this season, and North Carolina’s offense hasn’t been clicking like it was earlier. 

The Pick: North Carolina State +6.5

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Michigan at Ohio State, Nov. 26, Noon ET

It doesn’t get any better than this. The unbeaten rivals will meet in Columbus with a trip to the Big Ten title on the line, one year after Michigan snapped an eight-game losing streak to the Buckeyes with a 42-27 upset in Ann Arbor. The Wolverines haven’t beaten Ohio State twice in a row since 1999-2000, but they’re right back in position after running the table to this point. 

Michigan survived a scare at Illinois to get here, while Ohio State finally pulled away from Maryland for a 43-30 win that was closer than the score indicates. Now it’s time to play for all the marbles, with a title game spot and likely CFP bid on the line at the Horseshoe. 

Of all the factors in this game, we’re looking at Ohio State’s defense. The Buckeyes were relatively weak on that end a year ago and made up for it with one of the most explosive offenses in the country. They haven’t slowed down much in that regard, but the defense has shown drastic improvement and ranks ninth overall. Michigan is still dominant in the trenches, but the Wolverines are one-dimensional and this is perhaps the most complete Ohio State team we’ve seen in years. This is a huge revenge game in Ann Arbor, and it won’t end well for Jim Harbaugh & Co. 

The Pick: Ohio State -7.5

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Auburn at Alabama, Nov. 26, 3:30 p.m. ET

The Iron Bowl is one of those games that tends to deliver regardless of circumstances. Alabama was a three-touchdown favorite last year and scored with less than 30 seconds left in regulation to eventually pull off a 24-22 victory in quadruple overtime. Now the Tide are three-score favorites again, but they’re out of the CFP race. Auburn has won back-to-back games over Texas A&M and Western Kentucky under interim coach Cadillac Williams and would love to make things interesting again to close out a tumultuous season. 

It's possible this is just a slightly above-average Alabama team, coasting on reputation and unworthy of three-touchdown favorite status. We still don’t believe it. We expect the Tide to pound the run all afternoon against an Auburn defense that gave up 276 yards on the ground the last time it saw a decent rushing attack. With a CFP spot out of the question, crushing the rivals in the home finale is the next best thing. 

The Pick: Alabama -22

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Oregon at Oregon State, Nov. 26, 3:30 p.m. ET

USC clinched a spot in the Pac 12 title game with an impressive win over UCLA. Oregon stayed alive in the race with an upset win over Utah and now has a chance to secure its spot with a win over the in-state rival Beavers. The Ducks are slight road favorites, but Oregon State has won two of the last three in Corvallis – including a 41-38 upset in 2020.  

Oregon quarterback Bo Nix gave one of the grittiest performances of his career against the Utes and made the difference down the stretch. This is another challenging week against a strong defense that will limit the Ducks on the ground, but we like Oregon to gut out another close win and get back to the conference championship game. 

The Pick: Oregon -3

Iowa State at TCU, Nov. 26, 4 p.m. ET

The Horned Frogs escaped with another close win Saturday at Baylor, and TCU is now just one game away from its first unbeaten regular season since 2010. TCU is favored by double digits for just the second time this season and covered in both games prior. Meanwhile, the Cyclones have been a disaster following a 3-0 start. They’ve lost seven of the last eight and are just 2-6 ATS in that time. 

It’s hard to overstate the pressure that’s been building up on the Horned Frogs each week. They’ve handled it every step of the way, but the final test is a tricky one against a strong Cyclones defense. And quarterback Hunter Dekkers could hit on a few big plays against a below-average TCU secondary. The Horned Frogs should get it done, but we’re expecting a sweat. 

The Pick: Iowa State +10

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Notre Dame at USC, Nov. 26, 7:30 p.m. ET

The Irish have dominated this rivalry for much of the decade, but USC looks poised to turn the tides. The Trojans are set for a Pac 12 title game showdown next week and still have a legit shot at the CFP depending on how things shake out elsewhere. But Notre Dame is riding a five-game win streak after an 0-2 start to the year, including a 44-0 blowout win last week over Boston College. This is a great chance to finish strong under first-year coach Marcus Freeman, who’s answered the doubters with a highly-impressive two-month stretch. 

Fascinating matchup here with an elite Notre Dame secondary taking on that Trojans passing attack. The Irish have held opponents under 191 passing yards in four of the last five games, and they’ve been just as good against the run. USC won’t achieve its normal balance and Notre Dame should be able to hang tough in the trenches. We’re officially putting the Trojans on upset alert. 

The Pick: Notre Dame +5.5

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Kansas at Kansas State, Nov. 26, 8 p.m. ET

Kansas State’s path is very simple – the Wildcats can clinch a spot in the Big 12 championship game to face TCU with a win Saturday over the Jayhawks. Kansas hasn’t beaten its in-state rival since 2008, racking up 13 straight losses against the Wildcats. But Kansas is no longer a laughingstock despite recent losses vs. Texas Tech and Texas. This is a great chance for the Jayhawks to end the regular season on a high note and carry momentum into their first bowl practices since 2008. 

Kansas State is the type of team that’s given the Jayhawks fits this year. They’re strong and balanced on offense and good enough against the run to limit Kansas offensively. There’s so much on the line for the Wildcats with a chance at the Big 12 title game and first outright conference championship since 2003. It’s been a blast watching Kansas turn things around this season, but they’re running out of gas ahead of a very tough matchup. 

The Pick: Kansas State -12 

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