Week 7 College Football Best Bets: Ohio State, Indiana Meet For Big Ten Supremacy

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The biggest Big Ten game of the season takes place Saturday at Bloomington, Indiana as the unbeaten national champion Hoosiers face Ohio State. Curt Cignetti's team has won 22 straight, but is less-than-stellar against the line. IU rallied past Nebraska with a pair of 4th-quarter TDs Saturday. Ohio State continued to demolish anyone not named Texas. This game tops our Week 7 College Football Betting Best Bets.
The Fox Big Noon Kickoff crew heads to Indiana. Kickoff is, naturally, at 12 p.m.
ESPN's GameDay goes West for the BYU-Notre Dame "Holy War" in Provo.
The SEC schedule claimed another victim in Week 6 as Kirby Smart, Gunner Stockton and the refs triple-teamed Alabama in Tuscaloosa.
Week 7 Bets Bets: Other Key Games To Watch
Week 7 doubles as Elimination Week across the Power Four. In the SEC, Alabama and Tennessee resume hostilities at Checkered Neyland Stadium; and Missouri visits Ole Miss. All four teams are ranked but each have one SEC loss. A second conference loss all but ends their shot an SEC Championship Game spot and a college football playoff berth. Elsewhere in the SEC, Georgia and Auburn continue the Deep South's Oldest Rivalry as they meet for the 131st time since 1892
The Big Ten features a suprising battle of unbeaten-in-conference foes in Wisconsin and UCLA.
In the Big 12, Arizona State faces Texas Tech in a must-win-to-stay-in-the-Big 12-title-chase game for the Sun Devils. Houston and Cincinnati also rest on the precipice of elimination from consideration with one conference loss apiece.
We continue this year's wondrous run of 61 straight nights of football with college games on Tuesday, Wednesday, Thursday and Friday evenings.
Week 7 Bets Bets: Game-By-Game Breakdown
Here are Week 7 College Football Best Bets. All odds from FanDuel via OddsJam. Potential Conference Elimination Games are noted.
CFB Week 7 Best Bets
Bookies.com Picks · FanDuel Odds Via OddsJam


Buzz
The Huskies continued their breathtaking fall from pre-season respectability with their third straight loss in the Big Ten, a 41-24 home loss to Iowa. Purdue stunned Minnesota Saturday 41-13 as Fame Ijeboi ran for 195 yards and 3 TDs — the Boilermakers are officially "The Biggest Surprise In The Big Ten" this season. Friday night, they get the national spotlight at home amid what should be a packed Ross-Ade Stadium.


Buzz
Our model sees the Bearcats winning by 5.2 points, despite being installed as 1.5-point underdogs. West Virginia's defense is the problem — Rich Rodriguez called it the "worst defense in college football" after Saturday. Cincinnati is coming off a bye and West Virginia is coming off a blowout loss at home. Take the over and look away.


Buzz
College football's least inspiring rivalry name — the Sunflower Showdown — models with K-State winning by 14.8 points, significant value against the 9.5-point number. But not so fast: not even a model can measure the intensity both teams bring to these games. The Jayhawks can score — they put up 24 and Isaiah Marshall threw for 333 yards in their loss to Utah. K-State's defense offers opportunity; big plays from KU keep this one under the number, and we may be sniffing an upset.


Buzz
The Gators got swamped by South Carolina Saturday. Texas, meanwhile, suffered a hit-and-run loss as the Sooner Schooner rolled through the Cotton Bowl with a stunning 27-24 upset over the then-No. 1 Longhorns — Arch Manning threw a pair of fourth-quarter interceptions, including his first-ever pick six, in the loss. Florida's offense is broken, and its tattered defense gives Arch and Sark a perfect get-right opportunity. With one SEC loss already, there's no room for mercy when it comes to running up the score — if Arch doesn't throw it away more than once.


Buzz
The past two national champions have one loss combined this season (OSU to Texas), but the edge here belongs to the Buckeyes on the betting line. The 6-0 Hoosiers are just 1-5 ATS this season, and despite winning 22 straight outright, IU has posted a tepid 12-10 record ATS during that span. Our model rates this as a coin toss, with Indiana winning by just 0.6 points — a tempting value play, but IU's ATS number flashes red. The Bucks re-assert Big Ten primacy in a hard-fought but decisive road victory.


Buzz
Death Valley loses its mystique and aura at 11 a.m. local time. Lane Kiffin's Tigers got caught in the Kroger Field trap, losing outright 35-34 in overtime at Kentucky as 10.5-point favorites. With two SEC losses, it's on to the portal and 2027 for LSU. Mississippi State remains a pesky out on the road, with wins at South Carolina and Minnesota — our model has LSU winning by 11.5, but the intangibles lean toward the Bulldogs, who are coming off a bye.


Buzz
Neither team is over .500 on the line. Our model sees SMU winning by 8.7 against a 7.5-point early-week line. SMU is coming off a bye and at home with QB Kevin Jennings in his fifth year with the program, but that hook on a touchdown line for an intra-conference ACC game is a warning sign — we saw Virginia play the underdog role well in a 28-25 win at Syracuse as 8.5-point favorites. Both teams remain viable in the ACC title game hunt with one loss; the loser is out, meaning a competitive, close game.


Buzz
Texas Tech moved into the top 10 while on the bye this week — rested and at home, our model has them winning by 18.5 points, significant value against this number. The Raiders remain in flux at QB; RB Cameron Dickey (ankle) is expected to sit, and WR Donte Lee Jr. (knee) may as well. ASU's plan here is run ball, run clock and keep this one under two scores going into the fourth quarter, but Tech remains in playoff-or-bust mode and pulls away late.


Buzz
Georgia and Auburn continue the Deep South's Oldest Rivalry, meeting for the 131st time since 1892. Georgia sits atop the college football world after its referee-aided win at Tuscaloosa — Kirby Smart's offense dominated the Tide by keeping the ball on the ground, mixing in a handful of chunk plays. Look for a steady, grinding attack against Auburn as the Dawgs eye the bye with a perfect record. Our model has Georgia winning by 19.4, slightly above this line — the Bulldogs (and the refs) held Alabama to just 17 points, and Auburn in Athens might not crack double digits.


Buzz
Have we already reached "loser is out" stage for Alabama and Tennessee? It's hard to imagine the math for any two-loss SEC team earning a trip to Atlanta in December. Kalen DeBoer raged after a missed pass-interference call and a late personal foul sealed Alabama's 20-17 loss to Georgia. Our model gives the Tide a 4.1-point victory, a value play for the Vols — Checkered Neyland is a big home-field edge, but Tennessee's QB situation remains cloudy. The under is the play here.


Buzz
We may see the Tigers in the SEC championship game, but few expected the breed to be from Columbia rather than Baton Rouge. Eli Drinkwitz has his 'Cats prowling atop the SEC and deep in the hunt for a title game berth. Mizzou QB Austin Simmons, WR Cayden Lee and DB Chris Graves Jr. all transferred out of Ole Miss in the offseason and return to Oxford. Our model sees a one-point game going to Ole Miss, giving Missouri a significant discount — Missouri's defense held a top-15 Texas A&M team to 6 points after destroying Florida, but this is Missouri's is-it-for-real road test. Ole Miss and Trinidad Chambliss can score almost at will, but they need the ball first.


Buzz
These Hurricanes have stalled in the top five and don't appear to be going anywhere, and Mario Cristobal won't allow his team to lay off the gas — especially against the Seminoles. Florida State last won a road game on November 25, 2023, and its road woes continue in Miami Gardens. The 'Canes may well sniff 60 points.


Buzz
Call this one "Catholics vs. Converts." The Irish hung 58 points on Stanford while BYU outlasted Iowa State — this battle of unbeatens, the biggest game in Provo this century, carries more potential downside for Notre Dame. BYU can win out after this week and earn its Playoff berth with a Big 12 title game win; an Irish loss may wake up echoes of last season's Playoff snub. The altitude and attitude at LaVell Edwards Stadium will test QB C.J. Carr and Notre Dame's defense. BYU has covered in each of its 5 wins — take the points.


Buzz
Both teams come off the bye. Our model has Baylor winning by 5.7 points against a line of 6.5 — but TCU's offense is broken, having scored three touchdowns in three Power Four games. Baylor improves each week; coach Dave Aranda called its 55-19 win over ASU two weeks ago his team's most complete performance of the season. TCU's remodeled offense won't keep pace with the Bears and QB DJ Lagway.


Buzz
A loss here ends Houston's hopes for a Big 12 title game berth and Playoff spot. The Pokes rank among the biggest surprises in college football this season thanks to their win over Oregon — this is the first of two major Big 12 challenges for Oklahoma State, which plays Texas Tech next month. The Pokes have won four straight and sit 4-1 ATS, but our model sits on this line, favoring Houston by 4.3 points. Houston's balanced offense overwhelms OSU here, despite the Cougars owning one of the weakest home-field advantages in all of sports.


Buzz
The Big Ten rivalry we didn't know we wanted. The Badgers and Bruins are a combined 9-1 straight-up and 3-0 in the Big Ten. UCLA dominates against the number, covering in all five games including an outright 17-15 win at Oregon as 10.5-point underdogs — but starting QB Nico Iamaleava left that game with multiple injuries and did not return. This number suggests the Bruins go with Ty Dieffenbach at QB this week; still, UCLA wins with defense and the run game. The Badgers keep it close, but not close enough.


Buzz
This iteration of the Buffs is past its prime — Colorado continued its Mile High tumble with a loss to Texas Tech last week. Coming off a bye won't mean much against a Utah team that remains the No. 2 team in the Beehive State. The Utes won't be caught off guard, or looking forward to their Old Testament showdown with BYU in three weeks.


Buzz
The Huskers blew a late lead at home against Indiana Saturday, but hung on for the backdoor cover at +7.5 in their 20-17 loss. Our model sits on the number, giving Oregon a 6.4-point victory. With Dante Moore out, Oregon's offense has imploded — in the Ducks' 17-15 loss to UCLA, Dylan Raiola was 6-of-19 for 43 yards with a pair of picks as Oregon turned the ball over six times. Matt Rhule's team was one stop away from beating the No. 7 team in the nation. Can the Huskers thrive and grind on the road? Or more importantly, can they cover?
Week 7 Bets Bets: Game-By-Game Analysis
Here's the rundown of our Week 7 College Football Best Bets All times are listed as ET
don’t worry i’m here pic.twitter.com/yGyqpDWP7k
— Dubs (@DubsUW) October 9, 2026
Friday, October 16
Washington at Purdue — 8 p.m. (FOX)
Buzz: Our favorite college canine, Dubs, has moved on to basketball season. The Huskies continued their breathtaking fall from pre-season respectability with their third-straight loss in the Big Ten, a 41-24 home loss to Iowa. Purdue stunned Minnesota Saturday 41-13 as Fame Ijeboi ran for 195 yards and 3 TDs. The Boilermakers are officially "The Biggest Surprise In The Big Ten" this season. Friday night, they get the national spotlight at home amid what should be a packed Ross-Ade Stadium.
Best Bet: Purdue -2.5 (-124)— FanDuel via OddsJam

Saturday, October 17
Ohio State at Indiana — 12 p.m. (FOX)
Buzz: The past two national champions have one loss combined this season (OSU to Texas). But the edge here belongs to the Buckeyes when it comes to the betting line. The 6-0 Hoosiers are just 1-5 ATS this season. And despite winning 22 straight outright, IU has posted a tepid 12-10 record ATS during that span. Our model rates this as a coin toss, with Indiana winning by a whopping 0.6 points. Indiana remains a tempting value play against the number. But their ATS number flashes red. The Bucks (5-1/4-2 ATS) re-assert Big Ten primacy in a hard-fought but decisive road victory.
Cincinnati at West Virginia — 12 p.m. (TNT)
Best Bet: Ohio State -3.5 (-110) — FanDuel via OddsJam
Buzz: Our model sees the Bearcats winning by 5.2 points, despite being installed as 1.5-point underdogs. West Virginia's defense is the problem. Rich Rodriguez called it the "worst defense in college football" after Saturday. Cincinnati is coming off a bye and West Virginia is coming off a blowout loss at home. Take the over and look away.
Best Bet: Over 62.5 Points (-110) — FanDuel via OddsJam
Kansas at Kansas State — 12 p.m. (FS1)
Buzz: College Football's least inspiring rivalry name - The Sunflower Showdown - models with K-State winning by 14.8 points. That's significant value against the 9.5-point number. But not so fast, my friend. Not even "Superior Intelligence" can measure the intensity that both teams bring to these sorts of games. Its antithetical moniker notwithstanding. The Jayhawks can score - they put up 24 and Isaiah Marshall threw for 333 yards in their loss to Utah. K-State's defense offers opportunity. Big plays from KU keep this one under the number. And we may be sniffing an upset.
Best Bet: Kansas +9.5 (-110) — FanDuel via OddsJam
Florida at Texas — 12 p.m. (ABC)
Buzz: The Gators got swamped by South Carolina Saturday. Texas, meanwhile, suffered a hit-and-run loss as the Sooner Schooner rolled through the Cotton Bowl with a stunning 27-24 upset win over the No. 1 ranked Longhorns. Arch Manning threw a pair of 4th-quarter interceptions - including his first-ever pick six - in the loss. Florida's offense is broken. And its tattered defense gives Arch and Sark a perfect get-right opportunity. And given Texas' one SEC loss, there's no room for mercy when it comes to running up the score. If Arch doesn't throw it away more than once.
Best Bet: Texas -9.5 (-110) — FanDuel via OddsJam
Mississippi State at LSU — 12 p.m. (ESPN)
Buzz: Cats and Dogs reign in Baton Rouge. But Death Valley loses its mystique and aura at 11 a.m. local time. Lane Kiffin this season assembled the "Worst Team A Lot Of Money Can Buy" in Baton Rouge. Thank goodness LSU fans can laugh at those "Fansville" spots. Otherwise, their season has been a tearjerker. The Tigers got caught in the Kroger Field trap, losing outright 35-34 in overtime at Kentucky as 10.5-point favorites. With two SEC losses, it's on to the portal and 2027 for LSU (4-2/2-4 ATS). Mississippi State remains a pesky out on the road, with wins at South Carolina and Minnesota. Our model has LSU winning by 11.5, but the intangibles lean toward the Bulldogs, who are coming off a bye.
Best Bet: Mississippi State +105. (-110) — FanDuel via OddsJam
Virginia at SMU — 12 p.m. (CW)
Buzz: Neither team is over .500 on the line. Our model sees SMU winning by 8.7 against a 7.5-point early-week line. SMU is coming off a bye and is at home with a QB, Kevin Jennings, in his fifth year with the program. The flashing-red warning sign here: that hook on a touchdown line for an intra-conference ACC game. We saw that play out Saturday with Virginia scoring a 28-25 victory at worst-in-the-ACC Syracuse as 8.5-point favorites. Both teams remain viable in the ACC Championship Game hunt with one loss. The loser is out. That means a competitive, close game. Take the points.
Best Bet: Virginia +7.5 (-118)— FanDuel via OddsJam
Arizona State at Texas Tech — 3:30 p.m. (FOX)
Buzz: Texas Tech moved into the top 10 while on the bye this week. The Red Raiders are rested and at home. Our model has them winning by 18.5 points, a significant value against this number. The Raiders continue to remain in flux at QB. RB Cameron Dickey (ankle) is expected to sit, and WR Donte Lee Jr. (knee) may, as well. ASU's plan here is run ball, run clock and keep this one under 2 scores going into the 4th quarter. Tech remains in playoff-or-bust mode. Quality and quantity pull away late here.
Best Bet: Texas Tech -13.5 (-120)— FanDuel via OddsJam
Auburn at Georgia — 3:30 p.m. (ESPN)
Buzz: Georgia and Auburn continue the Deep South's Oldest Rivalry as they meet for the 131st time since 1892. The Tigers hope to keep it respectable Between The Hedges. Georgia (6-0/5-1 ATS) sits atop the College Football at the new No. 1-ranked team in The AP Top 25 after its referee-aided win at Tuscaloosa. Kirby Smart's offense (and the refs) dominated the Tide by keeping the ball on the ground, mixing it with a handful of chunk plays. Look for a steady, grinding attack against Auburn as the Dawgs eye the bye with a perfect record. Our model has Georgia winning by 19.4 points, slightly above this line. Lean into the under here. The Bulldogs (and the refs) held Keelon Russell and his Crimson Tide offense to just 17 points. Auburn in Athens might not crack double digits.
Best Bet: Under 49.5 Points (-110) — FanDuel via OddsJam
Alabama at Tennessee — 3:30 p.m. (ABC)
Buzz: Have we already reached "Loser Is Out Stage" for Alabama and Tennessee? Well, it's hard to imagine the math for any two-loss SEC team earning a trip to Atlanta in December. Kalen DeBoer raged at the world as the refs robbed his team on a missed pass-interference call in the end zone, then a late personal foul penalty on sophomore CB Dijon Lee Jr. sealed Alabama's fate in its 20-17 loss to Georgia. Our model gives the Tide a 4.1-point victory, a value play for the Vols. Checkered Neyland offers a lopsided home-field edge. But Tennessee's QB situation remains cloudy. The under is the play here.
Best Bet: Under 53.5 Points (-108) — FanDuel via OddsJam
Missouri at Ole Miss — 3:30 p.m. (SEC)
Buzz: We may see the Tigers in the SEC championship game. But few expected the breed to be from Columbia, not Baton Rouge. Eli Drinkwitz has his 'Cats prowling atop the SEC and deep in the hunt for a berth in the conference title game. Mizzou QB Austin Simmons, WR Cayden Lee and DB Chris Graves Jr. all transferred out of Ole Miss in the offseason and return to Oxford. Our model sees a one-point game going to Ole Miss, giving Missouri a significant discount. Missouri's defense held a No. 14 Texas A&M team to 6 points after destroying Florida. But this is Missouri's is-it-for-real road test in Oxford. Ole Miss remains in the SEC hunt, but needs to run the table for a title-game spot. Ole Miss and Trinidad Chambliss can score almost at will. But they need the ball first.
Best Bet: Missouri +6.5 (-110) — FanDuel via OddsJam
Florida State at Miami — 7 p.m. (ESPN)
Buzz: These Hurricanes have stalled in the top three and don't appear to be going anywhere. Mario Cristobal won't allow his team to lay off the gas. Especially against the Seminoles. Florida State last won a road game on November 25, 2023 (at Gainesville). Their road woes continue in Miami Gardens. The 'Canes may well sniff 60 points.
Best Bet: Miami -20.5 (-110) — FanDuel via OddsJam
Cougar fans, it’s been awhile 💭
— College GameDay (@CollegeGameDay) October 10, 2026
We’re headed to Provo for the first time since 2009 for Notre Dame-BYU‼️ pic.twitter.com/gWSLxrpBkN
Notre Dame at BYU — 7:30 p.m. (ABC)
Buzz: Call this one "Catholics vs. Converts." The Irish hung 58 points on Stanford, while BYU outlasted Iowa State. This battle of unbeatens, which is the biggest game in Provo this century, carries more potential downside for Notre Dame. BYU can win out after this week and earn its College Football Playoff berth with a victory in the Big 12 title game. An Irish loss may wake up the echoes of last season's College Football Playoff snub. The altitude and attitude at LaVell Edwards Stadium, where the get-in price was $451 as of Sunday, will test QB C.J. Carr and Notre Dame's defense. BYU has covered in each of its 5 wins. Take the points. Leave the caffeine.
Best Bet: BYU +12.5 (-110) — FanDuel via OddsJam
TCU at Baylor — 7:30 p.m. (FS1)
Buzz: Both teams come off the bye. Our model has Baylor winning by 5.7 points against a line of 6.5 points. But TCU's offense is broken. The Horned Frogs have scored three touchdowns in three Power Four games and remain functionally dysfunctional. Baylor improves each week. Coach Dave Aranda called their 55-19 win over ASU two weeks ago his team's most-complete performance of the season. TCU's remodeled offense won't be able to keep pace with the Bears and QB DJ Lagway.
Best Bet: Baylor -6.5 (-105) FanDuel via OddsJam
Oklahoma State at Houston — 7:30 p.m. (FOX)
Buzz: A loss here ends Houston's hopes for a Big 12 title game berth and CFB Playoff spot. The Pokes rank among the biggest surprises on the upside in college football this season thanks to a win over Oregon. This is first of two major Big 12 challenges for Oklahoma State. It plays Texas Tech next month. OSU has won four straight and sit 4-1 ATS. Our model sits on this line, favoring Houston by 4.3 points. Houston's balanced offense (4 TD passes; 233 yards rushing, led by Re'Shaun Sanford's 90, at K-State) overwhelms OSU here, despite the Cougars owning the weakest "home field advantage" in all of sports.
Best Bet: Houston -4.5 (-105) — FanDuel via OddsJam
Wisconsin at UCLA — 7:30 p.m. (NBC)
Buzz: The Big Ten Rivalry we didn't know we wanted, but now can't live without. The Badgers and Bruins are combined 9-1 SU and 3-0 in the Big Ten. UCLA dominates against the number, covering in all five games, including an outright 17-15 win at Oregon Saturday as 10.5-point underdogs. But starting QB Nico Iamaleava left the game with multiple injuries and did not return. He's out for the year. This number suggests that the Bruins will go with QB Ty Dieffenbach this week. Still, UCLA wins with defense and the run game. The Badgers keep it close, but not close enough.
Best Bet: UCLA -3.5 (-110) — FanDuel via OddsJam
Utah at Colorado — 10:15 p.m. (ESPN)
Buzz: This iteration of the Buffs is past its Prime. Colorado continued its Mile High tumble last week with a loss to Texas Tech. Coming off a bye won't mean much against a Utah team that remains the No. 2 team in the Beehive State. The Utes won't be caught off guard, or looking forward to their Old Testament showdown with BYU in three weeks.
Best Bet: Utah -16.5 (-106) — FanDuel via OddsJam
Nebraska at Oregon — 11 p.m. (FOX)
Buzz: The Huskers blew a late lead at home against Indiana Saturday, but hung on for the backdoor cover at +7.5 in their 20-17 loss. Our model sits on the number, giving Oregon a 6.4-point victory. With Moore out, Oregon's offense has imploded without Dante Moore. In the Ducks' 17-15 loss to UCLA, Dylan Raiola was 6-of-19 for 43 yards with a pair of picks as Oregon turned over the ball six times. Matt Rhule's team was one stop away from beating the No. 7 team in the nation. Can the Huskers thrive and grind on the road? Or more importantly, can they cover?
Best Bet: Nebraska +6.5 (-110) — FanDuel via OddsJam

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