Bill Speros for Bookies.com

By Bill Speros | | 6 mins

NFL Week 2 Betting Lines, Odds & Schedule With Marquee Games

NFL Week 2 Betting Lines, Odds & Schedule With Marquee Games

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The season doesn’t begin until Sept. 9, but NFL betting is already available for the first two weeks of the season – plus other key games – are up at multiple sports betting sites.

The marquee matchups in Week 2 include the Kansas City Chiefs visiting Baltimore on Sunday night, an offensive showcase between the Dallas Cowboys and Los Angeles Chargers and a key AFC East clash between the Buffalo Bills and Miami Dolphins.

Here is the complete NFL Week 2 schedule with the latest available NFL betting lines via DraftKings:

Game Spread ML Time/TV
Giants at Washington WAS -3.5 NYG +128; WAS -157 (Sept. 16) 8 p.m. FOX
Saints at Panthers NO -2.5 NO -159; CAR +130 1 p.m. FOX
LA Rams at ColtsLAR -1.5 LAR -118; IND -104 1 p.m. FOX
49ers at Eagles SF -5 SF -230; PHI +186 1 p.m. FOX
Raiders at Steelers PIT -5.5 LVR +190; PIT -240 1 p.m. CBS
Bills at Dolphins BUF -2.5 BUF -148; MIA +120 1 p.m. CBS
Bengals at Bears CHI -5 CIN +190; CHI -240 1 p.m. CBS
Patriots at Jets NE -4NE -215; NYJ +170 1 p.m. CBS
Texans at Browns CLE -12.5HOU +480; CLE -715 1 p.m. CBS
Broncos at Jaguars DEN -2.5DEN -150; JAX +123 1 p.m. CBS
Falcons at Bucs TB -7.5ATL +275; TB -360 4:05 p.m. FOX
Vikings at Cardinals ARI -1.5MIN +107; ARI -130 4:05 p.m. FOX
Cowboys at Chargers LAC -1.5DAL +100; LAC -121 4:25 p.m. FOX
Titans at Seahawks SEA -4.5TEN +160; SEA -200 4:25 p.m. CBS
Chiefs at Ravens KC -2KC -129; BAL +1068:20 p.m. NBC
Lions at Packers GB -7.5DET +260; GB -335(Sept. 20) 8:15 p.m. ESPN

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This will be the second week of a 17-game season with the AFC team getting the extra home game. The final Sunday of the NFL season is Jan. 9, 2022.


RELATED: NFL Week 1 Betting Lines, Odds & Schedule


NFL Week 2 Schedule Highlights

Chiefs at Ravens: This one is simple: Patrick Mahomes versus Lamar Jackson. Two potential future faces of the NFL – once Tom Brady retires – meet in a potential AFC playoff preview. This game will carry plenty of juice for bettors and fans coming down off the inevitable sugar-high from Opening Week.

Both Kansas City and Baltimore face tough Week 1 opponents. The Chiefs begin their season against the Cleveland Browns, who have emerged as a threat in the AFC North. The Ravens, who have the second-toughest NFL strength of schedule, open at Allegiant Stadium against the Raiders. That game features NFL fans for a regular-season game in Las Vegas for the first time.

Mahomes and Jackson won league MVP honors in 2018 and 2019, respectively. Each is a legit contender for the same honor this season. Mahomes is the +500 outright league favorite at Unibet. Jackson sits sixth on same site at +1600.


CHECK OUT: The Latest NFL MVP Odds


The Chiefs have been to two straight Super Bowls. They carry lofty expectations across NFL futures odds as +260 betting favorites at 888sport to three-peat as AFC champions. The Ravens are +650 to win the AFC at FanDuel.

NFL Week 2 Betting Lines, Odds & Schedule With Marquee Games 1

Bills at Dolphins: The road to the AFC East title now goes through Buffalo. This game offers an early test to see how well Buffalo can handle a strong divisional rival on the road. The Bills open at home against Pittsburgh in Week 1, while the Dolphins visit the Patriots. The Dolphins went all-in on Tua Tagovailoa at quarterback in the offseason and drafted his former Alabama teammate WR Jaylen Waddle. Josh Allen and the Bills’ multifaceted offense provide an early tell-all test for Miami’s defense.

Cowboys at Chargers: This game should be an offensive showcase and a fun play for bettors and fans, alike. The total on this one should be in the mid-to-high 50s. Dak Prescott should be able to spread Dallas’ offense. Meanwhile, Chargers QB Justin Herbert lit up the NFL last season, setting rookie records for total TDs (36), TD passes (31) and completions (396). Even though Dallas bolstered its defense in the draft, the Cowboys defense was a chain link fence trying to stop a tsunami last year. Herbert may go for 400+ yards passing here.


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Setting NFL Lines On Beyond Week 1?

The growth and spread of legal sports betting have turned the posting of betting lines on individual regular-season games into the norm.

The lines for Week 2 of the season were up less than 24 hours after the complete NFL schedule was officially released by the league. This will be just the fourth NFL season since PASPA was overturned. And as is the case in so much when it comes to betting: More is better. Several books posted lines on key regular-season NFL games following the release of the schedule.

But the release of spreads and moneylines for the full Week 2 schedule this far out is a first.

“For me, personally, it’s way different. I never used to go past Week 1," said DraftKings Race and Sports Betting Director Johnny Avello, who began his career writing tickets in Las Vegas in the late 1970s. "Some operators used to put up games of the year. We’re getting pretty aggressive now. We know that football is a sport that everyone likes to wager on. Once we know what the schedules are, we put up a lot of content. It’s kind of fun for a bettor.”

The posting of any game line this far out carries a steep risk, especially concerning injury.

NFL Week 2 Betting Lines, Odds & Schedule With Marquee Games 2

“One injury changes a lot. It changes not only Week 1, it changes Week 2. It changes the futures. It changes the division odds. It changes the conference odds. It changes everything. You have to stay on top of everything. Every single day,” Avello said.

And that risk is only partly offset by the increased betting handle on a random Week 1 or Week 2 game posted this far ahead of kickoff.

“We do it for a few reasons," Avello said. "We do it for some marketing. We do it because we know people love football and they want to see lines. If you have a Week 1, they’ll say ‘What would you make Week 2?’ If you have Week 2 up but don’t have Week 3, they’ll say: ‘When will Week 3 be?’ You get it all up and answer those questions. People like to talk about it. They don’t necessarily bet it, but they talk about it.”


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