No team has ever won three Super Bowls in a row. Patrick Mahomes and the Kansas City Chiefs are primed to give it a go when the 2024 NFL season kicks off on Thursday, Sept. 5. 

Mahomes and the Chiefs kick things off on opening night against Lamar Jackson and the Baltimore Ravens. The Chiefs enter the season betting favorites to win the Super Bowl at +550 futures odds. The San Francisco 49ers, who the Chiefs beat in a thrilling Super Bowl 2024, are right behind KC at +600. 

The Ravens are +900, and the Detroit Lions and Buffalo Bills are each at +1200 to round out the top 5. 

The Week 1 schedule is out. Don’t think it matters? Consider that the eventual Super Bowl champion is 45-11-1 all-time in their opening games. 

Read ahead to find out Bookies.com veteran oddsmaker Adam Thompson's sports betting tips on who to watch out for on 2024 NFL Week 1. You can also bet on the games at your favorite betting apps.

Thursday, Sept. 5

Baltimore Ravens at Kansas City Chiefs, 8:20 p.m. ET (NBC)

In 2023 the Ravens ranked sixth in total offense and total defense, and fourth in points – and they still couldn’t get past Patrick Mahomes and the Chiefs in the AFC. KC beat Baltimore in the AFC Championship game, in Baltimore. Now the immediate rematch, as the Chiefs begin defense of another Super Bowl crown. 

KC’s success last season wasn’t all on the shoulder of Mahomes. The defense ranked No. 2 in points and yards allowed. The team upgraded a dismal WR room with Marquise “Hollywood” Brown and a potential standout in rookie Xavier Worthy. One team makes a big statement on Opening Night. 

Friday, Sept. 6

Green Bay Packers vs. Philadelphia Eagles, 8:15 p.m. ET (Peacock)

Last year was supposed to be a transition season for the Packers, who started a new era without Aaron Rodgers and the youngest team in the NFL. But Jordan Love progressed quickly. After a tough 2-5 start, the Packers went 6-2 down the stretch – Love had 18 TDs and just one INT in that span – to get to the playoffs, then rough up the Cowboys. 

The Eagles had an opposite trajectory in 2023. They looked like Super Bowl favorites when they were 10-1. But they flamed out, losing five of their final six before a 32-9 whopping by Baker Mayfield’s Buccaneers in the playoffs. Coach Nick Siriani gets another shot to right the ship. The offense added Saquon Barkley, but it’s the defense – a defense that ranked 30th in points allowed – to keep the eyes on. 

Sunday, Sept. 8

Pittsburgh Steelers at Atlanta Falcons, 1 p.m. ET (FOX)

The Kenny Pickett era in Pittsburgh lasted all of 24 games, but when your QB throws 13 TDs and 13 INTs in those 24, a change is warranted. With a veteran defense ready to compete, the Steelers went out and got a veteran QB with a championship resume in Russell Wilson. Does Wilson have anything left in the tank? 

Speaking of new QBs, the Falcons made the off-season’s biggest splash by signing Kirk Cousins to a massive four-year, $160 million deal (then drafting a QB in the Top 10, but that’s another story for another time). They then added WRs Darnell Mooney and Ronalde Moore, giving Atlanta, on paper, one of the premier offenses in the NFL. Major issues weren’t addressed nearly as well on the defensive side, however. 

Arizona Cardinals at Buffalo Bills, 1 p.m. ET (CBS)

Kyler Murray is back at QB for the Cardinals, who are coming off consecutive 4-13 seasons. The team added Marvin Harrison Jr. to be his top to-go guy, and improved massive issues on the O-line and defensive backfield. Improvement is expected in Jonathan Gannon’s second year as coach. 

While the Cardinals improved by addition, the Bills hope a retooling by subtraction will get them over the hump in the AFC. Gone are WRs Stefon Diggs and Gabe Davis, plus a few standouts on defense. Younger players will be asked to keep up. And they do still have Josh Allen, who in 2023 finished in the Top 5 of MVP voting for the third time in four years. 

Tennessee Titans at Chicago Bears, 1 p.m. ET (FOX)

Mike Vrabel is out after six seasons as coach of the Titans. The team took steps back the last three seasons, so offensive guru Brian Callahan takes over to breathe new life into the team. Will Levis get his first full year as a starter, with Tony Pollard in at RB to replace workhorse Derrick Henry? The Titans spent much of the off-season shoring up a porous line. 

The Bears spent their off-season adding weapons for new QB Caleb Williams, the celebrated No. 1 overall pick out of USC. D’Andre Swift is the new RB, and Keenan Allen and rookie Rome Odunze were added to catch passes alongside DJ Moore. Chicago has ranked in the upper half of the NFL in scoring just twice in the last 18 years. It’s a realistic expectation now.

New England Patriots at Cincinnati Bengals, 1 p.m. ET (CBS)

Bill Belichick protégé Jerod Mayo takes over as head coach of the Patriots, signaling a completely new era in Foxborough. The defense-minded coach will need to revamp one of the bottom offenses in the league. It started at No. 3 in the NFL Draft, taking future starting QB Drake Maye. Issues across the rest of the offense will persist, but this off-season was Step 1 in righting the ship. 

The Bengals hope that getting QB Joe Burrow for a full season does the trick. He’s managed two near-full seasons in four years, and the team went 10-7 and 12-4 in those two years. Last year he managed only 10 games, but the offensive line was reworked to help keep Burrow on the field. The high-octane offense may have to again bail out a defense that last year ranked 26^th or worse vs. both the run and the pass 

Houston Texans at Indianapolis Colts, 1 p.m. ET (CBS)

To say CJ Stroud was just what the Texans needed would be a massive understatement. After going 3-13-1 in 2022, the Texans, with Stroud at QB and new coach DeMeco Ryan on the headset, finished 10-7 and advanced to the playoffs for the first time since 2019. The team had a go-for-it mentality in the off-season, adding Edge rusher Danielle Hunter from the Vikings, RB Joe Mixon from the Bengals, and WR Stefon Diggs from the Bills. Houston isn’t messing around. 

The Colts finished a respectable 9-8, a fantastic improvement from a 4-12-1 effort the year prior. Rookie QB Anthony Richardson missed most of the season, but Gardner Minshew did his thing. The plan appears to be to run it back with Richardson, as the Colts spent much of the off-season re-signing their key guys. Defense was the issue for Indy, which it addressed in the NFL Draft (Laiatu Latu on the line). 

Jacksonville Jaguars at Miami Dolphins, 1 p.m. ET (CBS)

After going 3-14 in 2021, the Jaguars went 9-8 with a postseason berth in 2022. But the team didn’t take another step forward in 2023, going 9-8 again but missing the playoffs by going 1-5 down the stretch. QB Trevor Lawrence’s numbers dipped across the board last season. The team added Gabe Davis from the Bills and Brian Thomas Jr. in the draft but lost Calvin Ridley to the Titans. 

The Dolphins gained more yards and scored the second-most points in the NFL last season. But a late dip resulted in a second-place finish in the AFC East and a first-round blowout loss to the Chiefs. Miami lost several key players on both sides of the ball but added just as many. Time will tell if the defense can hold up its end of the bargain. 

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Carolina Panthers at New Orleans Saints, 1 p.m. ET (FOX)

The Panthers went 2-15 and had traded away the No. 1 overall pick to the Bears the season prior. So new coach Dave Canales has his work cut out for him, especially after losing defensive stars Brian Burns to the Giants and Frankie Luvu to the Commanders. Bryce Young gets a reboot at QB, and the team added young, if unpolished, talent in the draft. 

The Saints finished 9-8 last season but just missed out on the postseason. Still, the team finished Top 10 in both points scored and points allowed, and could be improved thanks to the jettisoning of pricey veterans who had lost a step, and immediate-impact rookies on the O-line and D-backfield. Derek Carr quietly had his best season since his Oakland Raiders days. 

Minnesota Vikings at New York Giants, 1 p.m. ET (FOX)

Kirk Cousins is now in Washington, so the offense is now in the hands of either journeyman Sam Darnold or rookie J.J. McCarthy. Whoever it is, they’ll have one of the premier skillset groups in the NFL around him, with Justin Jefferson and Jordan Addison catching passes and electric RB Aaron Jones in town from Green Bay. The team lost edge rusher Danielle Hunter but added two edges in Andrew Van Ginkel and Jonathan Greenard. If the Vikings can get dependable QB play, they could be an early surprise team. 

After a semi-surprise 9-7-1 season and playoff berth in 2022, the Giants slipped back to 6-11 last season (which was still tied for their second-most wins since 2016). Daniel Jones is back from a torn ACL, but Saquon Barkley is now in rival Philadelphia. The offense overhauled an O-line that was the worst in the league, while the defense, which was just as bad, gets a big boost from Brian Burns.

Las Vegas Raiders at Los Angeles Chargers, 4:05 p.m. ET (CBS)

The Raiders improved two games to 8-9 last season with interim coach Antonio Pierce and a messy QB situation. Pierce is now the head coach, and Gardner Minshew was brought in to lead an offense that ranked 23rd in scoring and 27th in yardage. The Raiders added TE Brock Bowers in the draft (despite using their first-round pick last year on Michael Mayer), but the question is if last year’s Top 10 scoring defense can do it again. 

The Chargers are in a reset season. After going 10-7 in 2022, the team plummeted to just 5-12. Jim Harbaugh was brought in to coach, but the cap-strapped Chargers had to move on from many of its higher-priced players. They’re replaced largely by unproven but potential-laden rookies and second-year guys. Justin Herbert is still slinging it, however. 

Denver Broncos at Seattle Seahawks, 4:05 p.m. ET (CBS)

The 2023 Broncos season felt like a disaster, but in reality, the team improved from 5-12 to 8-9, somehow doing so despite ranking 26th in yards gained and 29th in yards allowed. Russell Wilson is gone, and so are several other veterans due to cap issues (LB Justin Simmons, OL Lloyd Cushenberry, and WR Jerry Jeudy the most notable). First-round pick Bo Nix is penciled in as QB1. 

The Seahawks didn’t make the playoffs but did finish 9-8, the same record as 2022 when they did get into the postseason. Pete Carroll is out as coach, but Ravens DC Mike Macdonald was a good hire and can help rebound a defense that ranked 25th in scoring and 30th in yardage. QB Geno Smith must rebound from a season in which he threw for 600 fewer yards and 10 fewer TDs, and his completion percentage dropped over 5%. 

Dallas Cowboys at Cleveland Browns, 4:25 p.m. ET (FOX)

Three straight 12-5 seasons haven’t been enough to quell Cowboys fans, who haven’t seen their team even get to an NFC Championship game since the days of Barry Switzer nearly three decades ago. They didn’t do much in free agency and lost a few key veterans, including OT Tyron Smith. They upgraded on the lines at the draft, but is it enough for Big D to take that elusive next step? 

Cleveland went 11-6 and to the playoffs behind the heroic arm of Joe Flacco. Now Deshaun Watson is back in the fold, Nick Chubb is back from his bad leg injury, and the Browns' defense is back after leading the NFL in fewest yards allowed in 2023. If Watson finds his Texans form, expectations will be high.

Washington Commanders at Tampa Bay Buccaneers, 4:25 p.m. ET (FOX)

The Commanders bottomed out in 2023 at 4-13, costing coach Ron Rivera his job. Sam Howell was traded to Seattle, and now we begin the Jayden Daniels era in the nation’s capital. They also added Austin Ekeler to the offense and built up all levels of a defense that last year was absolutely the worst in the NFL. There’s reason for actual optimism in D.C. 

The Buccaneers should also be happy running it back after going 9-8 and into the postseason in Year One without Tom Brady. Baker Mayfield and his top weapons were all re-signed. The defense held mostly steady, not a bad thing since it ranked No. 7 in points allowed. This could lowkey be a Game of the Week contender. 

Los Angeles Rams at Detroit Lions, 8:20 p.m. ET (NBC)

Many pundits believed 2023 would be the end of the Rams dynasty, especially after a dismal 2022 season. But Sean McVay, Matthew Stafford, and Aaron Donald found a way, propelling L.A. to a 10-7 record and playoff berth. Donald is now retired, but the team added a slew of potential depth parts that could keep them in the NFC chase. 

The Lions are hoping to pick up where they left off. They knocked out the Rams from the playoffs last year following a 12-5 season, their best since 1991. They spent the off-season bulking up the defensive front seven, added two play-now cornerbacks in the draft, and re-signed their top offensive players. Could the Lions finally get to the Super Bowl? The pieces are in place. 

Monday, Sept. 9

New York Jets at San Francisco 49ers, 8:15 p.m. ET (ESPN/ABC)

Aaron Rodgers lasted just a few short plays in his Jets debut last year, and the Jets’ season tanked without him. Now he’s back and with a revamped O-line in front of him and a defense that ranked No. 3 in yards allowed. Keeping QB12 upright is the key; Rodgers plays and the Jets are in the hunt. 

The Niners didn’t do much in free agency or add any key named at the draft, but they didn’t have to. They’re the reigning NFC champions who ranked No. 3 in the NFL in both points scored and points allowed. They’re aiming for a fourth NFC Championship Game appearance and third Super Bowl berth in six years.