One team has already clinched a playoff berth while the other needs to win out and get some help, as Drew Brees and the New Orleans Saints host Jacoby Brissett and the Indianapolis Colts on Monday Night Football.

RELATED: Colts-Saints MNF Betting Preview

The Saints (10-3) have covered the spread just once in their last six Monday night games, while the Colts are 6-2-2 ATS in their last 10 on the road.

Let’s take a look at some of the best bets fans of NFL betting should consider:

Colts-Saints Best Bets

OTHER BETS TO BACK

• First Turnover | Colts -140 (William Hill)
• Total Match TDs | Over 5.5 +138 (DraftKings)
• Both Teams Score 20 Points | +154 (FanDuel)

All odds current as of publication but subject to change. Check out the latest Colts-Saints odds here.

PICK 1: Colts +9.5

The Colts have seven losses, but six of them were by a TD or less. They need to win and they need help, so the sense of urgency should be high. The Saints have 10 wins, but eight of them were by eight points or less. They’re just 2-4 against the spread at home. Indy is on a 12-2 ATS heater against above-.500 teams.

PICK 2: Over 45.5 Points

The Under has been the theme of Colts and Saints games overall, but the Over has hit in five of their last six Monday night appearances for each.

The last seven Colts games featuring a healthy Brissett and Marlon Mack have averaged 48.1 ppg. Most of those games weren’t against an opponent with the offensive strength of the Saints.

Pick 3: First Turnover — Colts

Both defenses have shown a talent for getting the ball from opponents. The difference is on the other side of the ball. New Orleans doesn’t turn it over. The Saints’ plus-11 in turnover differential ranks No. 3 in the NFL. The Colts have a season differential of zero.

CHECK OUT: Bookies.com NFL Week 15 Betting Power Rankings

PICK 4: Total Match TDs — Over 5.5

The Colts’ last game featured a huge 10 total TDs. That’s nothing compared to the Saints shootout with the 49ers, a thrilling game that finished with 12 TDs. Both teams are subpar against the pass. Five of the last six Monday night games have totaled at least 51 points, and the Saints’ lone appearance on MNF this season totaled 58.

PICK 5: Both Teams Score 20 Points

The Colts average 22.3 points per game, but that number jumps to 25.0 when Brissett and Mack are both in the lineup. The Saints, of course, can score with the best of them. Neither side should be completely shut down by the opposing defense, which rank 16th and 17th in points allowed.

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