Week 10 of the NFL season ends with a bang, as the unbeaten San Francisco 49ers play host to the hard-charging Seattle Seahawks on Monday Night Football.

The 49ers (8-0) are a whopping 27-7 against the spread in their last 34 Monday Night Football games, but the Seahawks (7-2) have covered in eight of their last 10 road games.

RELATED: Seahawks-49ers MNF Betting Preview

Let’s take a look at some of the best bets fans of NFL betting should consider:

Seahawks-49ers Best Bets

OTHER BETS TO BACK

• First Score | 49ers TD +155 (FanDuel)
• Second Half | 49ers -2.5 -110 (William Hill)
• First Turnover | 49ers +105 (William Hill)

All odds current as of publication but subject to change. Check out the latest Seahawks-49ers odds here.

PICK 1: Seahawks +6.5

The Seahawks are 11-3-1 against the spread in the last 15 matchups with the 49ers, including 5-2 ATS in San Francisco. The Seahawks have covered both times as an underdog (in fact, they’ve won straight up both times).

The 49ers have been dominant this season, but they’re most-marquee win was a 20-7 victory over the Rams without Todd Gurley. San Francisco ranks No. 2 in sacks and No. 4 in INTs but Russell Wilson may be the NFL MVP at this point. If the 49ers defense isn’t creating opportunities for the offense, this should be a very close game.

PICK 2: Over 46.5 Points

San Francisco’s defense ranks No. 1 in the NFL in fewest yards allowed and No. 2 in points allowed. But it also just gave up 25 points to Arizona and was torched equally by Kyler Murray and Kenyan Drake.

Seattle ranks fourth in yards and since Week 2, at least one team in Seahawks games has scored at least 27 points and they’re averaging 28.5 ppg on the road. The 49ers will get theirs, too, especially facing Seattle’s 27th-ranked pass defense.

PICK 3: First Score – 49ers TD

San Francisco has been a hotter-starting team this season, but the proof is in the pudding. The 49ers have started three of their eight games with TDs. The Seahawks have scored first in their games just twice in nine outings, and the opponent has opened scoring with TDs four times. Look for another quick start for San Francisco.

CHECK OUT: Bookies.com NFL Week 10 Betting Power Rankings

PICK 4: Second Half – 49ers -2.5

The Seahawks are 7-2 because they blow the competition away in the second quarter, averaging a league-high 13.3 ppg the last three weeks alone (and 10.0 ppg the entire season). They’ve found ways to win late but it’s rarely been easy. In fact, Seattle has actually been outscored in the second halves of games. That is definitely not the case for the 49ers, who are more-than doubling up their competition, on average 15.8 ppg to 7.4.

PICK 5: First Turnover – 49ers

Each team has created 16 turnovers this season, but the 49ers turn the ball over more than the Seahawks. Each team averages fewer than one fumble per game (and most of Seattle’s came in the opening three weeks).

Wilson has thrown just one INT all season. Jimmy Garoppolo has seven INTs in eight games. The price is right to back a 49ers turnover.

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